The prevalence and associated risk factors of post-transplant Toxoplasma gondii infection among kidney transplant recipients and patients with uremia in Central-southern China.
<h4>Background</h4>Toxoplasma gondii (T. gondii) is an opportunistic intracellular parasite and is a big threaten for patients with uremia and solid organ transplantation recipients, especially for kidney transplant recipients. However, Toxoplasma seroprevalence in these patient populati...
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Public Library of Science (PLoS)
2025-05-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0013063 |
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| author | Xingxing Zheng Junhui Li Zhuolin Li Xianshu Liu Yufei Zhang Jiang Zhu Yu Zhang Jie Jiang Bo Li Meng Xia Yingzi Ming Xiang Wu |
| author_facet | Xingxing Zheng Junhui Li Zhuolin Li Xianshu Liu Yufei Zhang Jiang Zhu Yu Zhang Jie Jiang Bo Li Meng Xia Yingzi Ming Xiang Wu |
| author_sort | Xingxing Zheng |
| collection | DOAJ |
| description | <h4>Background</h4>Toxoplasma gondii (T. gondii) is an opportunistic intracellular parasite and is a big threaten for patients with uremia and solid organ transplantation recipients, especially for kidney transplant recipients. However, Toxoplasma seroprevalence in these patient populations remain unclear, and the risk factors of post transplantation T. gondii infection were not well-defined in China and globally.<h4>Methods</h4>Post-transplant or uremia patient's serum collected from transplant center of 3rd Xiangya hospital of Central South University were detected by IHA to detect anti-Toxoplasma IgG. A retrospective cross-sectional study was performed with these patient's medical records and a questionnaire was also conducted.<h4>Results</h4>The results indicated that approximately 10.59% of the kidney recipients in central-southern China were seropositive for T. gondii post-transplant. While the prevalence in patients with uremia was about 24.12%. We identified that keeping cats and a lower percentage of CD3+T cells and CD8+T cells were associated with higher prevalence of T. gondii IgG+ in uremia patients when compared with kidney transplant recipients.<h4>Conclusions</h4>This study suggested that kidney recipients and those uremia patients in the waiting list are susceptible to T. gondii infection. Immune status and keeping cats are associated with the seroprevalence in those patients. However, T. gondii infection is a neglected problem, screening and monitoring deserves more attention in the clinic. |
| format | Article |
| id | doaj-art-b7fd8ecb303341f98a0dde014f7809f6 |
| institution | DOAJ |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-b7fd8ecb303341f98a0dde014f7809f62025-08-20T02:39:44ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352025-05-01195e001306310.1371/journal.pntd.0013063The prevalence and associated risk factors of post-transplant Toxoplasma gondii infection among kidney transplant recipients and patients with uremia in Central-southern China.Xingxing ZhengJunhui LiZhuolin LiXianshu LiuYufei ZhangJiang ZhuYu ZhangJie JiangBo LiMeng XiaYingzi MingXiang Wu<h4>Background</h4>Toxoplasma gondii (T. gondii) is an opportunistic intracellular parasite and is a big threaten for patients with uremia and solid organ transplantation recipients, especially for kidney transplant recipients. However, Toxoplasma seroprevalence in these patient populations remain unclear, and the risk factors of post transplantation T. gondii infection were not well-defined in China and globally.<h4>Methods</h4>Post-transplant or uremia patient's serum collected from transplant center of 3rd Xiangya hospital of Central South University were detected by IHA to detect anti-Toxoplasma IgG. A retrospective cross-sectional study was performed with these patient's medical records and a questionnaire was also conducted.<h4>Results</h4>The results indicated that approximately 10.59% of the kidney recipients in central-southern China were seropositive for T. gondii post-transplant. While the prevalence in patients with uremia was about 24.12%. We identified that keeping cats and a lower percentage of CD3+T cells and CD8+T cells were associated with higher prevalence of T. gondii IgG+ in uremia patients when compared with kidney transplant recipients.<h4>Conclusions</h4>This study suggested that kidney recipients and those uremia patients in the waiting list are susceptible to T. gondii infection. Immune status and keeping cats are associated with the seroprevalence in those patients. However, T. gondii infection is a neglected problem, screening and monitoring deserves more attention in the clinic.https://doi.org/10.1371/journal.pntd.0013063 |
| spellingShingle | Xingxing Zheng Junhui Li Zhuolin Li Xianshu Liu Yufei Zhang Jiang Zhu Yu Zhang Jie Jiang Bo Li Meng Xia Yingzi Ming Xiang Wu The prevalence and associated risk factors of post-transplant Toxoplasma gondii infection among kidney transplant recipients and patients with uremia in Central-southern China. PLoS Neglected Tropical Diseases |
| title | The prevalence and associated risk factors of post-transplant Toxoplasma gondii infection among kidney transplant recipients and patients with uremia in Central-southern China. |
| title_full | The prevalence and associated risk factors of post-transplant Toxoplasma gondii infection among kidney transplant recipients and patients with uremia in Central-southern China. |
| title_fullStr | The prevalence and associated risk factors of post-transplant Toxoplasma gondii infection among kidney transplant recipients and patients with uremia in Central-southern China. |
| title_full_unstemmed | The prevalence and associated risk factors of post-transplant Toxoplasma gondii infection among kidney transplant recipients and patients with uremia in Central-southern China. |
| title_short | The prevalence and associated risk factors of post-transplant Toxoplasma gondii infection among kidney transplant recipients and patients with uremia in Central-southern China. |
| title_sort | prevalence and associated risk factors of post transplant toxoplasma gondii infection among kidney transplant recipients and patients with uremia in central southern china |
| url | https://doi.org/10.1371/journal.pntd.0013063 |
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