Colorectal cancer spectrum: From subtypes and epidemiology to oncotherapies
Colorectal cancer (CRC) has an incidence rate of 10 % and is the third most common cause of mortality worldwide, following breast and lung cancer. The clinical symptoms of CRC appear in the last phases of the disease and there is a substantial golden period between the formation of polyps and the o...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-04-01
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| Series: | Gastroenterology & Endoscopy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949752325000020 |
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| author | Nidhi Agrawal S.K. Lanjhiyana Meenakshi Jaiswal Mohammad Akbar Siddiqui Sakshi Gupta |
| author_facet | Nidhi Agrawal S.K. Lanjhiyana Meenakshi Jaiswal Mohammad Akbar Siddiqui Sakshi Gupta |
| author_sort | Nidhi Agrawal |
| collection | DOAJ |
| description | Colorectal cancer (CRC) has an incidence rate of 10 % and is the third most common cause of mortality worldwide, following breast and lung cancer. The clinical symptoms of CRC appear in the last phases of the disease and there is a substantial golden period between the formation of polyps and the onset of cancer. There are many traditional options available for the treatment of CRC, such as surgery, chemotherapy, radiation therapy, etc. Although there have been significant advancements in conventional therapies, the management and prevention of CRC are still relatively challenging due to disease reoccurrence and resistance to chemotherapy. Recently, novel strategies including targeted therapy and immunotherapy have emerged as novel possibilities for treating CRC. The present article provides an overview of the molecular subtypes, epidemiology, carcinogenesis, risk factors, diagnostic approaches, and recent advancements in therapeutic options for the treatment of CRC. |
| format | Article |
| id | doaj-art-b7f503e4463244039a53170bccb3a343 |
| institution | Kabale University |
| issn | 2949-7523 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Gastroenterology & Endoscopy |
| spelling | doaj-art-b7f503e4463244039a53170bccb3a3432025-02-12T05:33:12ZengKeAi Communications Co., Ltd.Gastroenterology & Endoscopy2949-75232025-04-01325564Colorectal cancer spectrum: From subtypes and epidemiology to oncotherapiesNidhi Agrawal0S.K. Lanjhiyana1Meenakshi Jaiswal2Mohammad Akbar Siddiqui3Sakshi Gupta4Corresponding author.; Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, 495009, IndiaDepartment of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, 495009, IndiaDepartment of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, 495009, IndiaDepartment of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, 495009, IndiaDepartment of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, 495009, IndiaColorectal cancer (CRC) has an incidence rate of 10 % and is the third most common cause of mortality worldwide, following breast and lung cancer. The clinical symptoms of CRC appear in the last phases of the disease and there is a substantial golden period between the formation of polyps and the onset of cancer. There are many traditional options available for the treatment of CRC, such as surgery, chemotherapy, radiation therapy, etc. Although there have been significant advancements in conventional therapies, the management and prevention of CRC are still relatively challenging due to disease reoccurrence and resistance to chemotherapy. Recently, novel strategies including targeted therapy and immunotherapy have emerged as novel possibilities for treating CRC. The present article provides an overview of the molecular subtypes, epidemiology, carcinogenesis, risk factors, diagnostic approaches, and recent advancements in therapeutic options for the treatment of CRC.http://www.sciencedirect.com/science/article/pii/S2949752325000020Colorectal cancerSubtypesEpidemiologyChemotherapyTargeted therapy |
| spellingShingle | Nidhi Agrawal S.K. Lanjhiyana Meenakshi Jaiswal Mohammad Akbar Siddiqui Sakshi Gupta Colorectal cancer spectrum: From subtypes and epidemiology to oncotherapies Gastroenterology & Endoscopy Colorectal cancer Subtypes Epidemiology Chemotherapy Targeted therapy |
| title | Colorectal cancer spectrum: From subtypes and epidemiology to oncotherapies |
| title_full | Colorectal cancer spectrum: From subtypes and epidemiology to oncotherapies |
| title_fullStr | Colorectal cancer spectrum: From subtypes and epidemiology to oncotherapies |
| title_full_unstemmed | Colorectal cancer spectrum: From subtypes and epidemiology to oncotherapies |
| title_short | Colorectal cancer spectrum: From subtypes and epidemiology to oncotherapies |
| title_sort | colorectal cancer spectrum from subtypes and epidemiology to oncotherapies |
| topic | Colorectal cancer Subtypes Epidemiology Chemotherapy Targeted therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2949752325000020 |
| work_keys_str_mv | AT nidhiagrawal colorectalcancerspectrumfromsubtypesandepidemiologytooncotherapies AT sklanjhiyana colorectalcancerspectrumfromsubtypesandepidemiologytooncotherapies AT meenakshijaiswal colorectalcancerspectrumfromsubtypesandepidemiologytooncotherapies AT mohammadakbarsiddiqui colorectalcancerspectrumfromsubtypesandepidemiologytooncotherapies AT sakshigupta colorectalcancerspectrumfromsubtypesandepidemiologytooncotherapies |