Potential of Polydatin Against Ischemia-Reperfusion Injury: New Insights from Pharmacological-Pathological Mechanism Associations
Zhicheng Sun,1– 3 Xiyang Wang,1– 3 Xiaoyang Pang1– 3 1Department of Spine Surgery, Xiangya Hospital of Central South University, Changsha, People’s Republic of China; 2Hunan Engineering Laboratory of Advanced Artificial Osteo-Materials, Xiangya Hospital, Central South University, Changsha, People’s...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-03-01
|
| Series: | Drug Design, Development and Therapy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/potential-of-polydatin-against-ischemia-reperfusion-injury-new-insight-peer-reviewed-fulltext-article-DDDT |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849761347335618560 |
|---|---|
| author | Sun Z Wang X Pang X |
| author_facet | Sun Z Wang X Pang X |
| author_sort | Sun Z |
| collection | DOAJ |
| description | Zhicheng Sun,1– 3 Xiyang Wang,1– 3 Xiaoyang Pang1– 3 1Department of Spine Surgery, Xiangya Hospital of Central South University, Changsha, People’s Republic of China; 2Hunan Engineering Laboratory of Advanced Artificial Osteo-Materials, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 3National Clinical Research Center of Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, People’s Republic of ChinaCorrespondence: Xiaoyang Pang, Department of Spine Surgery, Xiangya Hospital of Central South University, Changsha, People’s Republic of China, Email xiaoyangpang@163.comAbstract: Ischemia-reperfusion injury is a multi-tissue/organ susceptible and highly destructive disease. The complex pathological mechanisms of ischemia-reperfusion injury make its prevention and treatment highly challenging, and the development of novel drugs with pharmacological pleiotropy that can target multiple pathological mechanisms has become the focus of current drug research. Polydatin is a traditional Chinese medicine monomer with pleiotropic pharmacological effects, and existing research evidence suggests that polydatin has strong protective potential against ischemia-reperfusion injury. However, the mechanism of polydatin against ischemia-reperfusion injury is still unclear. In this review, the extensive pharmacological-pathological mechanism associations between polydatin and ischemia-reperfusion injury have been described from the perspectives of inflammatory response, oxidative stress, apoptosis, autophagy, ferroptosis, and cellular pyroptosis, which will provide references to the basic and applied research of polydatin in the field of ischemia-reperfusion injury.Keywords: polydatin, ischemia-reperfusion injury, pharmacological mechanism, pathological mechanism |
| format | Article |
| id | doaj-art-b7f0cd40a5994b32a9e8900b6fcd81ae |
| institution | DOAJ |
| issn | 1177-8881 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj-art-b7f0cd40a5994b32a9e8900b6fcd81ae2025-08-20T03:06:04ZengDove Medical PressDrug Design, Development and Therapy1177-88812025-03-01Volume 1915851594100846Potential of Polydatin Against Ischemia-Reperfusion Injury: New Insights from Pharmacological-Pathological Mechanism AssociationsSun ZWang XPang XZhicheng Sun,1– 3 Xiyang Wang,1– 3 Xiaoyang Pang1– 3 1Department of Spine Surgery, Xiangya Hospital of Central South University, Changsha, People’s Republic of China; 2Hunan Engineering Laboratory of Advanced Artificial Osteo-Materials, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 3National Clinical Research Center of Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, People’s Republic of ChinaCorrespondence: Xiaoyang Pang, Department of Spine Surgery, Xiangya Hospital of Central South University, Changsha, People’s Republic of China, Email xiaoyangpang@163.comAbstract: Ischemia-reperfusion injury is a multi-tissue/organ susceptible and highly destructive disease. The complex pathological mechanisms of ischemia-reperfusion injury make its prevention and treatment highly challenging, and the development of novel drugs with pharmacological pleiotropy that can target multiple pathological mechanisms has become the focus of current drug research. Polydatin is a traditional Chinese medicine monomer with pleiotropic pharmacological effects, and existing research evidence suggests that polydatin has strong protective potential against ischemia-reperfusion injury. However, the mechanism of polydatin against ischemia-reperfusion injury is still unclear. In this review, the extensive pharmacological-pathological mechanism associations between polydatin and ischemia-reperfusion injury have been described from the perspectives of inflammatory response, oxidative stress, apoptosis, autophagy, ferroptosis, and cellular pyroptosis, which will provide references to the basic and applied research of polydatin in the field of ischemia-reperfusion injury.Keywords: polydatin, ischemia-reperfusion injury, pharmacological mechanism, pathological mechanismhttps://www.dovepress.com/potential-of-polydatin-against-ischemia-reperfusion-injury-new-insight-peer-reviewed-fulltext-article-DDDTpolydatinischemia-reperfusion injurypharmacological mechanismpathological mechanism |
| spellingShingle | Sun Z Wang X Pang X Potential of Polydatin Against Ischemia-Reperfusion Injury: New Insights from Pharmacological-Pathological Mechanism Associations Drug Design, Development and Therapy polydatin ischemia-reperfusion injury pharmacological mechanism pathological mechanism |
| title | Potential of Polydatin Against Ischemia-Reperfusion Injury: New Insights from Pharmacological-Pathological Mechanism Associations |
| title_full | Potential of Polydatin Against Ischemia-Reperfusion Injury: New Insights from Pharmacological-Pathological Mechanism Associations |
| title_fullStr | Potential of Polydatin Against Ischemia-Reperfusion Injury: New Insights from Pharmacological-Pathological Mechanism Associations |
| title_full_unstemmed | Potential of Polydatin Against Ischemia-Reperfusion Injury: New Insights from Pharmacological-Pathological Mechanism Associations |
| title_short | Potential of Polydatin Against Ischemia-Reperfusion Injury: New Insights from Pharmacological-Pathological Mechanism Associations |
| title_sort | potential of polydatin against ischemia reperfusion injury new insights from pharmacological pathological mechanism associations |
| topic | polydatin ischemia-reperfusion injury pharmacological mechanism pathological mechanism |
| url | https://www.dovepress.com/potential-of-polydatin-against-ischemia-reperfusion-injury-new-insight-peer-reviewed-fulltext-article-DDDT |
| work_keys_str_mv | AT sunz potentialofpolydatinagainstischemiareperfusioninjurynewinsightsfrompharmacologicalpathologicalmechanismassociations AT wangx potentialofpolydatinagainstischemiareperfusioninjurynewinsightsfrompharmacologicalpathologicalmechanismassociations AT pangx potentialofpolydatinagainstischemiareperfusioninjurynewinsightsfrompharmacologicalpathologicalmechanismassociations |