Pre-post feasibility trial of a telephone-delivered exercise intervention for patients during chemotherapy for recurrent ovarian cancer: the ECHO-R trial protocol
Introduction The benefits of exercise in reducing treatment-related morbidity and improving quality of life following a primary diagnosis of cancer have been well documented and have led to exercise being recommended by oncology societies for all people with a cancer diagnosis. However, these recomm...
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BMJ Publishing Group
2024-01-01
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| author | Andreas Obermair Monika Janda Sandra C Hayes Elizabeth Eakin Marcelo Nascimento Dimitrios Vagenas Jermaine Coward Louisa G Gordon Catherine Shannon James Nicklin Jeffrey Goh Vanessa L Beesley Penny Webb Merran Williams Sheree Rye Rosalind R Spence Helene O’Neill Melissa J Newton Sara Baniahmadi Andrea Garret |
| author_facet | Andreas Obermair Monika Janda Sandra C Hayes Elizabeth Eakin Marcelo Nascimento Dimitrios Vagenas Jermaine Coward Louisa G Gordon Catherine Shannon James Nicklin Jeffrey Goh Vanessa L Beesley Penny Webb Merran Williams Sheree Rye Rosalind R Spence Helene O’Neill Melissa J Newton Sara Baniahmadi Andrea Garret |
| author_sort | Andreas Obermair |
| collection | DOAJ |
| description | Introduction The benefits of exercise in reducing treatment-related morbidity and improving quality of life following a primary diagnosis of cancer have been well documented and have led to exercise being recommended by oncology societies for all people with a cancer diagnosis. However, these recommendations are derived from research typically involving cohorts with more common cancers and relatively good prognosis, such as breast and prostate. Evidence from these cancers may not apply to women with recurrent ovarian cancer. Therefore, the primary objective of this trial is to evaluate the feasibility and safety of a home-based, telephone-delivered exercise intervention for women undergoing chemotherapy for recurrent ovarian cancer.Methods and analysis The Exercise During Chemotherapy for Recurrent Ovarian Cancer (ECHO-R) trial is a single-arm, phase II, pre/postintervention trial of a 6-month, telephone-delivered exercise intervention (consistent with recommended exercise oncology prescription). The target sample size is 80 women who are currently undergoing (or are scheduled to receive) chemotherapy for recurrent ovarian cancer. Recruitment is through participating hospital sites in Queensland, Australia, or via self-referral. The exercise intervention comprises 12 telephone sessions over a 6-month period delivered by trial-trained exercise professionals and supplemented (where feasible) by five sessions face to face. Exercise prescription is individualised and works towards an overall goal of achieving a weekly target of 150 min of moderate-intensity, mixed-mode exercise. Assessments via self-administered survey and physical fitness and function tests occur at baseline and then at 6 and 9 months postbaseline. Data to inform feasibility and safety are recorded as case notes by the exercise professional during each session.Ethics and dissemination Ethics approval for the ECHO-R trial was granted by the Metro North Human Research Ethics Committee (HREC/2020/QRBW/67223) on 6 November 2020. Findings from the trial are planned to be disseminated via peer-reviewed publications and both national and international exercise and oncology conferences.Trial registration number ACTRN12621000042842. |
| format | Article |
| id | doaj-art-b7ef6db7e6a94f2bafd0e601b80d58eb |
| institution | DOAJ |
| issn | 2044-6055 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | BMJ Publishing Group |
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| spelling | doaj-art-b7ef6db7e6a94f2bafd0e601b80d58eb2025-08-20T03:12:39ZengBMJ Publishing GroupBMJ Open2044-60552024-01-0114110.1136/bmjopen-2023-077158Pre-post feasibility trial of a telephone-delivered exercise intervention for patients during chemotherapy for recurrent ovarian cancer: the ECHO-R trial protocolAndreas Obermair0Monika Janda1Sandra C Hayes2Elizabeth Eakin3Marcelo Nascimento4Dimitrios Vagenas5Jermaine Coward6Louisa G Gordon7Catherine Shannon8James Nicklin9Jeffrey Goh10Vanessa L Beesley11Penny Webb12Merran Williams13Sheree Rye14Rosalind R Spence15Helene O’Neill16Melissa J Newton17Sara Baniahmadi18Andrea Garret19Queensland Centre for Gynaecological Cancer Research, The University of Queensland, Herston, Queensland, AustraliaCentre for Health Services Research, The University of Queensland, Woolloongabba, Queensland, AustraliaSchool of Health Sciences and Social Work, Menzies Health Institute Queensland, Griffith University, Nathan, Queensland, AustraliaFaculty of Medicine, School of Public Health, The University of Queensland, Brisbane, Queensland, AustraliaGold Coast University Hospital, Southport, Queensland, AustraliaSchool of Public Health and Social Work, Queensland University of Technology Faculty of Health, Kelvin Grove, Queensland, AustraliaFaculty of Medicine and ICON Cancer Care Centre, The University of Queensland, Brisbane, Queensland, AustraliaPopulation Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, AustraliaQueensland Centre for Gynaecological Cancer Research, The University of Queensland, Herston, Queensland, AustraliaGynaecological Cancer, Royal Brisbane and Women`s Hospital, Herston, Queensland, Australia4ICON Cancer Centre Wesley, Auchenflower QLD 4066, Brisbane, QLD, AustraliaPopulation Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, AustraliaPopulation Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, AustraliaQueensland Centre for Gynaecological Cancer Research, The University of Queensland, Herston, Queensland, AustraliaSchool of Health Sciences and Social Work, Menzies Health Institute Queensland, Griffith University, Nathan, Queensland, AustraliaMenzies Health Institute Queensland, Griffith University, Brisbane, Queensland, AustraliaQueensland Centre for Gynaecological Cancer Research, The University of Queensland, Herston, Queensland, AustraliaSchool of Health Sciences and Social Work, Menzies Health Institute Queensland, Griffith University, Nathan, Queensland, AustraliaQueensland Centre for Gynaecological Cancer Research, The University of Queensland, Herston, Queensland, AustraliaQueensland Centre for Gynaecological Cancer Research, The University of Queensland, Herston, Queensland, AustraliaIntroduction The benefits of exercise in reducing treatment-related morbidity and improving quality of life following a primary diagnosis of cancer have been well documented and have led to exercise being recommended by oncology societies for all people with a cancer diagnosis. However, these recommendations are derived from research typically involving cohorts with more common cancers and relatively good prognosis, such as breast and prostate. Evidence from these cancers may not apply to women with recurrent ovarian cancer. Therefore, the primary objective of this trial is to evaluate the feasibility and safety of a home-based, telephone-delivered exercise intervention for women undergoing chemotherapy for recurrent ovarian cancer.Methods and analysis The Exercise During Chemotherapy for Recurrent Ovarian Cancer (ECHO-R) trial is a single-arm, phase II, pre/postintervention trial of a 6-month, telephone-delivered exercise intervention (consistent with recommended exercise oncology prescription). The target sample size is 80 women who are currently undergoing (or are scheduled to receive) chemotherapy for recurrent ovarian cancer. Recruitment is through participating hospital sites in Queensland, Australia, or via self-referral. The exercise intervention comprises 12 telephone sessions over a 6-month period delivered by trial-trained exercise professionals and supplemented (where feasible) by five sessions face to face. Exercise prescription is individualised and works towards an overall goal of achieving a weekly target of 150 min of moderate-intensity, mixed-mode exercise. Assessments via self-administered survey and physical fitness and function tests occur at baseline and then at 6 and 9 months postbaseline. Data to inform feasibility and safety are recorded as case notes by the exercise professional during each session.Ethics and dissemination Ethics approval for the ECHO-R trial was granted by the Metro North Human Research Ethics Committee (HREC/2020/QRBW/67223) on 6 November 2020. Findings from the trial are planned to be disseminated via peer-reviewed publications and both national and international exercise and oncology conferences.Trial registration number ACTRN12621000042842.https://bmjopen.bmj.com/content/14/1/e077158.full |
| spellingShingle | Andreas Obermair Monika Janda Sandra C Hayes Elizabeth Eakin Marcelo Nascimento Dimitrios Vagenas Jermaine Coward Louisa G Gordon Catherine Shannon James Nicklin Jeffrey Goh Vanessa L Beesley Penny Webb Merran Williams Sheree Rye Rosalind R Spence Helene O’Neill Melissa J Newton Sara Baniahmadi Andrea Garret Pre-post feasibility trial of a telephone-delivered exercise intervention for patients during chemotherapy for recurrent ovarian cancer: the ECHO-R trial protocol BMJ Open |
| title | Pre-post feasibility trial of a telephone-delivered exercise intervention for patients during chemotherapy for recurrent ovarian cancer: the ECHO-R trial protocol |
| title_full | Pre-post feasibility trial of a telephone-delivered exercise intervention for patients during chemotherapy for recurrent ovarian cancer: the ECHO-R trial protocol |
| title_fullStr | Pre-post feasibility trial of a telephone-delivered exercise intervention for patients during chemotherapy for recurrent ovarian cancer: the ECHO-R trial protocol |
| title_full_unstemmed | Pre-post feasibility trial of a telephone-delivered exercise intervention for patients during chemotherapy for recurrent ovarian cancer: the ECHO-R trial protocol |
| title_short | Pre-post feasibility trial of a telephone-delivered exercise intervention for patients during chemotherapy for recurrent ovarian cancer: the ECHO-R trial protocol |
| title_sort | pre post feasibility trial of a telephone delivered exercise intervention for patients during chemotherapy for recurrent ovarian cancer the echo r trial protocol |
| url | https://bmjopen.bmj.com/content/14/1/e077158.full |
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