Computational investigation unveils pathogenic LIG3 non-synonymous mutations and therapeutic targets in acute myeloid leukemia.

Computational investigation unveils pathogenic LIG3 non-synonymous mutations and therapeutic targets in acute myeloid leukemia.

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Single nucleotide polymorphisms (SNPs) in DNA repair genes can impair protein structure and function, contributing to disease development, including cancer. Non-synonymous SNPs (nsSNPs) in the LIG3 gene are linked to genomic instability and increased cancer risk, particularly acute myeloid leukemia...

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Main Authors: Md Arif Hossen, Umme Mim Sad Jahan, Md Arju Hossain, Khalid Hossain Asif, Ahona Rahman, Sabbir Ahmed, Md Moin Uddin, Md Faisal Amin, Muhammad Abdul Barik, Mohammod Johirul Islam, Mohammad Kamruzzaman, Soharth Hasnat, Mohammad Nasir Uddin, Tofazzal Islam, M Nazmul Hoque
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0320550
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