Pathophysiology and Treatment of Psoriasis: From Clinical Practice to Basic Research
Psoriasis, a chronic inflammatory dermatosis, represents a significant clinical challenge due to its complex pathogenesis and the limitations of existing therapeutic strategies. Current psoriasis diagnoses are primarily clinician-dependent, with instrumental diagnostics serving as adjuncts. Ongoing...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/17/1/56 |
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| author | Yujie Gao Tianqi Xu Yu Wang Yanjinhui Hu Shaoping Yin Zhiguo Qin Hua Yu |
| author_facet | Yujie Gao Tianqi Xu Yu Wang Yanjinhui Hu Shaoping Yin Zhiguo Qin Hua Yu |
| author_sort | Yujie Gao |
| collection | DOAJ |
| description | Psoriasis, a chronic inflammatory dermatosis, represents a significant clinical challenge due to its complex pathogenesis and the limitations of existing therapeutic strategies. Current psoriasis diagnoses are primarily clinician-dependent, with instrumental diagnostics serving as adjuncts. Ongoing research is progressively deciphering its molecular underpinnings; the future of psoriasis diagnostics may involve genetic and immunological profiling to pinpoint biomarkers, enabling more accurate and timely interventions. The administration of psoriasis medications, whether oral, injectable, or topical, is associated with a range of side effects and compliance issues. Topical medications, despite their advantages in patient compliance and reduced systemic side effects, are hindered by the altered skin barrier in psoriasis, which impedes effective drug penetration and retention. In recent years, the development of novel transdermal drug delivery systems represents a promising frontier in psoriasis management. Nanotechnology-, microneedle- and dressing-based systems have demonstrated the potential for improved skin penetration, enhanced bioavailability, or extended retention time. Here, we will focus on the latest insights into the etiology, diagnostic methodologies, and therapeutic approaches for psoriasis, with a particular emphasis on the evolution and challenges of novel transdermal drug delivery systems. |
| format | Article |
| id | doaj-art-b7e6a353ab8b4bb4a960be312e9c963c |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-b7e6a353ab8b4bb4a960be312e9c963c2025-01-24T13:45:44ZengMDPI AGPharmaceutics1999-49232025-01-011715610.3390/pharmaceutics17010056Pathophysiology and Treatment of Psoriasis: From Clinical Practice to Basic ResearchYujie Gao0Tianqi Xu1Yu Wang2Yanjinhui Hu3Shaoping Yin4Zhiguo Qin5Hua Yu6State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, ChinaDepartment of Pharmacy, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, ChinaSchool of Pharmacy, Jiangsu Provincial Engineering Research Center of Traditional Chinese Medicine External Medication Development and Application, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaSchool of Pharmacy, Jiangsu Provincial Engineering Research Center of Traditional Chinese Medicine External Medication Development and Application, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaSchool of Pharmacy, Jiangsu Provincial Engineering Research Center of Traditional Chinese Medicine External Medication Development and Application, Nanjing University of Chinese Medicine, Nanjing 210023, ChinaDepartment of Pharmacy, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, ChinaPsoriasis, a chronic inflammatory dermatosis, represents a significant clinical challenge due to its complex pathogenesis and the limitations of existing therapeutic strategies. Current psoriasis diagnoses are primarily clinician-dependent, with instrumental diagnostics serving as adjuncts. Ongoing research is progressively deciphering its molecular underpinnings; the future of psoriasis diagnostics may involve genetic and immunological profiling to pinpoint biomarkers, enabling more accurate and timely interventions. The administration of psoriasis medications, whether oral, injectable, or topical, is associated with a range of side effects and compliance issues. Topical medications, despite their advantages in patient compliance and reduced systemic side effects, are hindered by the altered skin barrier in psoriasis, which impedes effective drug penetration and retention. In recent years, the development of novel transdermal drug delivery systems represents a promising frontier in psoriasis management. Nanotechnology-, microneedle- and dressing-based systems have demonstrated the potential for improved skin penetration, enhanced bioavailability, or extended retention time. Here, we will focus on the latest insights into the etiology, diagnostic methodologies, and therapeutic approaches for psoriasis, with a particular emphasis on the evolution and challenges of novel transdermal drug delivery systems.https://www.mdpi.com/1999-4923/17/1/56psoriasispathogenesisdiagnosisclinical treatmenttransdermal drug delivery system |
| spellingShingle | Yujie Gao Tianqi Xu Yu Wang Yanjinhui Hu Shaoping Yin Zhiguo Qin Hua Yu Pathophysiology and Treatment of Psoriasis: From Clinical Practice to Basic Research Pharmaceutics psoriasis pathogenesis diagnosis clinical treatment transdermal drug delivery system |
| title | Pathophysiology and Treatment of Psoriasis: From Clinical Practice to Basic Research |
| title_full | Pathophysiology and Treatment of Psoriasis: From Clinical Practice to Basic Research |
| title_fullStr | Pathophysiology and Treatment of Psoriasis: From Clinical Practice to Basic Research |
| title_full_unstemmed | Pathophysiology and Treatment of Psoriasis: From Clinical Practice to Basic Research |
| title_short | Pathophysiology and Treatment of Psoriasis: From Clinical Practice to Basic Research |
| title_sort | pathophysiology and treatment of psoriasis from clinical practice to basic research |
| topic | psoriasis pathogenesis diagnosis clinical treatment transdermal drug delivery system |
| url | https://www.mdpi.com/1999-4923/17/1/56 |
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