Vitamin E Attenuating Effects Against the Impact of the Herbicide Atrazine on the Diaphragm Muscle of Male Wistar Rats
Atrazine is an herbicide associated with respiratory disorders and the presence of oxidative stress, which can be reversed by association with antioxidant compounds, such as vitamin E. This study aimed to investigate the impact of atrazine (AZ) on the male rat diaphragm muscle and the attenuating ef...
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| Format: | Article |
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Wiley
2025-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/jt/7995780 |
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| author | Felipe Cantore Tiburcio Viviane da Silva Martins Lopes Correa Kevin Silva Muller Ana Paula Silveira Leite Carina Guidi Pinto Fabio Anselmo Antonio Francisco Godinho Carlos Roberto Padovani Ana Angelica Henrique Fernandes Shelly Favorito de Carvalho Selma Maria Michelin Matheus |
| author_facet | Felipe Cantore Tiburcio Viviane da Silva Martins Lopes Correa Kevin Silva Muller Ana Paula Silveira Leite Carina Guidi Pinto Fabio Anselmo Antonio Francisco Godinho Carlos Roberto Padovani Ana Angelica Henrique Fernandes Shelly Favorito de Carvalho Selma Maria Michelin Matheus |
| author_sort | Felipe Cantore Tiburcio |
| collection | DOAJ |
| description | Atrazine is an herbicide associated with respiratory disorders and the presence of oxidative stress, which can be reversed by association with antioxidant compounds, such as vitamin E. This study aimed to investigate the impact of atrazine (AZ) on the male rat diaphragm muscle and the attenuating effects of vitamin E. Fifty-two male rats were received for 28 days by gavage (n = 13/group): C (control), corn oil; AZ (100 mg/kg); AZE, AZ (100 mg/kg) and vitamin E (200 mg/kg); E, vitamin E (200 mg/kg). Both oxidative stress analysis and morphological analysis of the diaphragm muscle, neuromuscular junction (NMJ), and phrenic nerve were performed. Exposure to AZ caused oxidative stress in muscle fibers, as evidenced by the highest lipid hydroperoxide, and hydrophilic antioxidant capacity values in the AZ group. However, in the AZE group, these values were like those of the C group. The area and diameter of the muscle fiber were only larger in the E group. Exposure to AZ caused oxidative stress in the diaphragm muscle, but vitamin E attenuated these alterations and protected muscle fibers from the oxidative damage. Therefore, vitamin E may serve as a useful attenuating agent against AZ-induced oxidative stress in the skeletal muscle. |
| format | Article |
| id | doaj-art-b7e56eacb45648bdbd06fef3d149acbe |
| institution | DOAJ |
| issn | 1687-8205 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-b7e56eacb45648bdbd06fef3d149acbe2025-08-20T03:06:28ZengWileyJournal of Toxicology1687-82052025-01-01202510.1155/jt/7995780Vitamin E Attenuating Effects Against the Impact of the Herbicide Atrazine on the Diaphragm Muscle of Male Wistar RatsFelipe Cantore Tiburcio0Viviane da Silva Martins Lopes Correa1Kevin Silva Muller2Ana Paula Silveira Leite3Carina Guidi Pinto4Fabio Anselmo5Antonio Francisco Godinho6Carlos Roberto Padovani7Ana Angelica Henrique Fernandes8Shelly Favorito de Carvalho9Selma Maria Michelin Matheus10Medical SchoolMedical SchoolMedical SchoolMedical SchoolMedical SchoolToxicological Information and Assistance Center (Ciatox)Toxicological Information and Assistance Center (Ciatox)Division of BiostatisticsDivision of Chemistry and BiochemistryElectron Microscopy CenterDivision of AnatomyAtrazine is an herbicide associated with respiratory disorders and the presence of oxidative stress, which can be reversed by association with antioxidant compounds, such as vitamin E. This study aimed to investigate the impact of atrazine (AZ) on the male rat diaphragm muscle and the attenuating effects of vitamin E. Fifty-two male rats were received for 28 days by gavage (n = 13/group): C (control), corn oil; AZ (100 mg/kg); AZE, AZ (100 mg/kg) and vitamin E (200 mg/kg); E, vitamin E (200 mg/kg). Both oxidative stress analysis and morphological analysis of the diaphragm muscle, neuromuscular junction (NMJ), and phrenic nerve were performed. Exposure to AZ caused oxidative stress in muscle fibers, as evidenced by the highest lipid hydroperoxide, and hydrophilic antioxidant capacity values in the AZ group. However, in the AZE group, these values were like those of the C group. The area and diameter of the muscle fiber were only larger in the E group. Exposure to AZ caused oxidative stress in the diaphragm muscle, but vitamin E attenuated these alterations and protected muscle fibers from the oxidative damage. Therefore, vitamin E may serve as a useful attenuating agent against AZ-induced oxidative stress in the skeletal muscle.http://dx.doi.org/10.1155/jt/7995780 |
| spellingShingle | Felipe Cantore Tiburcio Viviane da Silva Martins Lopes Correa Kevin Silva Muller Ana Paula Silveira Leite Carina Guidi Pinto Fabio Anselmo Antonio Francisco Godinho Carlos Roberto Padovani Ana Angelica Henrique Fernandes Shelly Favorito de Carvalho Selma Maria Michelin Matheus Vitamin E Attenuating Effects Against the Impact of the Herbicide Atrazine on the Diaphragm Muscle of Male Wistar Rats Journal of Toxicology |
| title | Vitamin E Attenuating Effects Against the Impact of the Herbicide Atrazine on the Diaphragm Muscle of Male Wistar Rats |
| title_full | Vitamin E Attenuating Effects Against the Impact of the Herbicide Atrazine on the Diaphragm Muscle of Male Wistar Rats |
| title_fullStr | Vitamin E Attenuating Effects Against the Impact of the Herbicide Atrazine on the Diaphragm Muscle of Male Wistar Rats |
| title_full_unstemmed | Vitamin E Attenuating Effects Against the Impact of the Herbicide Atrazine on the Diaphragm Muscle of Male Wistar Rats |
| title_short | Vitamin E Attenuating Effects Against the Impact of the Herbicide Atrazine on the Diaphragm Muscle of Male Wistar Rats |
| title_sort | vitamin e attenuating effects against the impact of the herbicide atrazine on the diaphragm muscle of male wistar rats |
| url | http://dx.doi.org/10.1155/jt/7995780 |
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