Grape polyphenols reduce fasting glucose and increase hyocholic acid in healthy humans: a meta-omics study

Grape polyphenols reduce fasting glucose and increase hyocholic acid in healthy humans: a meta-omics study

Abstract Grape polyphenols (GPs) are rich in B-type proanthocyanidins, which promote metabolic resilience. Longitudinal metabolomic, metagenomic, and metaproteomic changes were measured in 27 healthy subjects supplemented with soy protein isolate (SPI, 40 g per day) for 5 days followed by GPs comple...

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Main Authors: Esther Mezhibovsky, Guojun Wu, Yue Wu, Zhibin Ning, Karen Bacalia, Sriya Sadangi, Riddhi Patel, Alexander Poulev, Rocio M. Duran, Marie Macor, Susette Coyle, Yan Y. Lam, Ilya Raskin, Daniel Figeys, Liping Zhao, Diana E. Roopchand
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Science of Food
Online Access:https://doi.org/10.1038/s41538-025-00443-6
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https://doi.org/10.1038/s41538-025-00443-6

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