Molecular mechanisms of CAND2 in regulating SCF ubiquitin ligases

Molecular mechanisms of CAND2 in regulating SCF ubiquitin ligases

Abstract Protein degradation orchestrated by SKP1·CUL1·F-box protein (SCF) ubiquitin ligases is a fundamental process essential for cellular and organismal function. The dynamic assembly of SCFs, facilitated by CAND1, ensures timely ubiquitination of diverse SCF target proteins. As a homolog of CAND...

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Bibliographic Details
Main Authors: Kankan Wang, Lihong Li, Sebastian Kenny, Dailin Gan, Justin M. Reitsma, Yun Zhou, Chittaranjan Das, Xing Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57065-5
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