A follow-up study on the recovery and reinfection of Omicron COVID-19 patients in Shanghai, China
Limited follow-up data is available on the recovery of Omicron COVID-19 patients after acute illness. It is also critical to understand persistence of neutralizing antibody (NAb) and of T-cell mediated immunity and the role of hybrid immunity in preventing SARS-CoV-2 reinfection. This prospective co...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2023.2261559 |
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| author | Mengna Lin Kangli Cao Feixiang Xu Xueling Wu Yao Shen Su Lu Zhongshu Kuang Hailin Ding Shuyun Yuan Mian Shao Guorong Gu Lingyu Xing Tianwen Gu Shaodie Chen Jian Sun Jiamin Zhu Xiaoyan Zhang Yilin Yang Guoping Zhao Lihong Huang Jianqing Xu Zhenju Song |
| author_facet | Mengna Lin Kangli Cao Feixiang Xu Xueling Wu Yao Shen Su Lu Zhongshu Kuang Hailin Ding Shuyun Yuan Mian Shao Guorong Gu Lingyu Xing Tianwen Gu Shaodie Chen Jian Sun Jiamin Zhu Xiaoyan Zhang Yilin Yang Guoping Zhao Lihong Huang Jianqing Xu Zhenju Song |
| author_sort | Mengna Lin |
| collection | DOAJ |
| description | Limited follow-up data is available on the recovery of Omicron COVID-19 patients after acute illness. It is also critical to understand persistence of neutralizing antibody (NAb) and of T-cell mediated immunity and the role of hybrid immunity in preventing SARS-CoV-2 reinfection. This prospective cohort study included Omicron COVID-19 individuals from April to June 2022 in Shanghai, China, during a large epidemic caused by the Omicron BA.2 variant. A total of 8945 patients from three medical centres were included in the follow up programme from November 2022 to February 2023. Of 6412 individuals enrolled for the long COVID analysis, 605 (9.4%) individuals experienced at least one sequelae, mainly had fatigue and mental symptoms specific to Omicron BA.2 infection compared with other common respiratory tract infections. During the second-visit, 548 (12.1%) cases of Omicron reinfection were identified. Hybrid immunity with full and booster vaccination had reduced risk of SARS-CoV-2 reinfection by 0.29-fold (95% CI: 0.63–0.81) and 0.23-fold (95% CI: 0.68–0.87), respectively. For 469 participants willing to the hospital during the first visit, those who received full (72 [IQR, 36–156]) or booster (64 [IQR, 28–132]) vaccination had significantly higher neutralizing antibody titers than those with incomplete vaccination (36 [IQR, 16–79]). Moreover, non-reinfection cases had higher neutralizing antibody titers (64 [IQR, 28–152]) compared to reinfection cases (32 [IQR, 20–69]). |
| format | Article |
| id | doaj-art-b7dbcfcb3b0b4f78af5ef76642eecce4 |
| institution | Kabale University |
| issn | 2222-1751 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-b7dbcfcb3b0b4f78af5ef76642eecce42025-08-20T03:31:10ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512023-12-0112210.1080/22221751.2023.2261559A follow-up study on the recovery and reinfection of Omicron COVID-19 patients in Shanghai, ChinaMengna Lin0Kangli Cao1Feixiang Xu2Xueling Wu3Yao Shen4Su Lu5Zhongshu Kuang6Hailin Ding7Shuyun Yuan8Mian Shao9Guorong Gu10Lingyu Xing11Tianwen Gu12Shaodie Chen13Jian Sun14Jiamin Zhu15Xiaoyan Zhang16Yilin Yang17Guoping Zhao18Lihong Huang19Jianqing Xu20Zhenju Song21Department of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaClinical Center for Bio-Therapy, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Respiratory Medicine, Renji hospital, Shanghai jiaotong University, School of medicine, 160 Pujian Road, Shanghai, ChinaDepartment of Respiratory and Critical Care Medicine, Shanghai Pudong Hospital, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaClinical Center for Bio-Therapy, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaState Key Laboratory of Genetic Engineering, Fudan Microbiome Center, School of Life Sciences, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Biostatistics, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaClinical Center for Bio-Therapy, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaLimited follow-up data is available on the recovery of Omicron COVID-19 patients after acute illness. It is also critical to understand persistence of neutralizing antibody (NAb) and of T-cell mediated immunity and the role of hybrid immunity in preventing SARS-CoV-2 reinfection. This prospective cohort study included Omicron COVID-19 individuals from April to June 2022 in Shanghai, China, during a large epidemic caused by the Omicron BA.2 variant. A total of 8945 patients from three medical centres were included in the follow up programme from November 2022 to February 2023. Of 6412 individuals enrolled for the long COVID analysis, 605 (9.4%) individuals experienced at least one sequelae, mainly had fatigue and mental symptoms specific to Omicron BA.2 infection compared with other common respiratory tract infections. During the second-visit, 548 (12.1%) cases of Omicron reinfection were identified. Hybrid immunity with full and booster vaccination had reduced risk of SARS-CoV-2 reinfection by 0.29-fold (95% CI: 0.63–0.81) and 0.23-fold (95% CI: 0.68–0.87), respectively. For 469 participants willing to the hospital during the first visit, those who received full (72 [IQR, 36–156]) or booster (64 [IQR, 28–132]) vaccination had significantly higher neutralizing antibody titers than those with incomplete vaccination (36 [IQR, 16–79]). Moreover, non-reinfection cases had higher neutralizing antibody titers (64 [IQR, 28–152]) compared to reinfection cases (32 [IQR, 20–69]).https://www.tandfonline.com/doi/10.1080/22221751.2023.2261559Long-COVIDneutralizing antibodyT-cell responsesreinfectioninactivated vaccination |
| spellingShingle | Mengna Lin Kangli Cao Feixiang Xu Xueling Wu Yao Shen Su Lu Zhongshu Kuang Hailin Ding Shuyun Yuan Mian Shao Guorong Gu Lingyu Xing Tianwen Gu Shaodie Chen Jian Sun Jiamin Zhu Xiaoyan Zhang Yilin Yang Guoping Zhao Lihong Huang Jianqing Xu Zhenju Song A follow-up study on the recovery and reinfection of Omicron COVID-19 patients in Shanghai, China Emerging Microbes and Infections Long-COVID neutralizing antibody T-cell responses reinfection inactivated vaccination |
| title | A follow-up study on the recovery and reinfection of Omicron COVID-19 patients in Shanghai, China |
| title_full | A follow-up study on the recovery and reinfection of Omicron COVID-19 patients in Shanghai, China |
| title_fullStr | A follow-up study on the recovery and reinfection of Omicron COVID-19 patients in Shanghai, China |
| title_full_unstemmed | A follow-up study on the recovery and reinfection of Omicron COVID-19 patients in Shanghai, China |
| title_short | A follow-up study on the recovery and reinfection of Omicron COVID-19 patients in Shanghai, China |
| title_sort | follow up study on the recovery and reinfection of omicron covid 19 patients in shanghai china |
| topic | Long-COVID neutralizing antibody T-cell responses reinfection inactivated vaccination |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2023.2261559 |
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