Identification of neoantigens derived from alternative splicing and RNA modification
The acquisition of somatic mutations is the most common event in cancer. Neoantigens expressed from genes with mutations acquired during carcinogenesis can be tumor-specific. Since the immune system recognizes tumor-specific peptides, they are potential targets for personalized neoantigen-based immu...
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| Language: | English |
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BioMed Central
2019-08-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gi-2019-17-3-e23.pdf |
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| author | Jiyeon Park Yeun-Jun Chung |
| author_facet | Jiyeon Park Yeun-Jun Chung |
| author_sort | Jiyeon Park |
| collection | DOAJ |
| description | The acquisition of somatic mutations is the most common event in cancer. Neoantigens expressed from genes with mutations acquired during carcinogenesis can be tumor-specific. Since the immune system recognizes tumor-specific peptides, they are potential targets for personalized neoantigen-based immunotherapy. However, the discovery of druggable neoantigens remains challenging, suggesting that a deeper understanding of the mechanism of neoantigen generation and better strategies to identify them will be required to realize the promise of neoantigen-based immunotherapy. Alternative splicing and RNA editing events are emerging mechanisms leading to neoantigen production. In this review, we outline recent work involving the large-scale screening of neoantigens produced by alternative splicing and RNA editing. We also describe strategies to predict and validate neoantigens from RNA sequencing data. |
| format | Article |
| id | doaj-art-b7d9469ea5bb43e6a08ff1375dd7d25b |
| institution | Kabale University |
| issn | 2234-0742 |
| language | English |
| publishDate | 2019-08-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-b7d9469ea5bb43e6a08ff1375dd7d25b2025-02-02T03:17:19ZengBioMed CentralGenomics & Informatics2234-07422019-08-0117310.5808/GI.2019.17.3.e23566Identification of neoantigens derived from alternative splicing and RNA modificationJiyeon Park0Yeun-Jun Chung1 Precision Medicine Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea Precision Medicine Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, KoreaThe acquisition of somatic mutations is the most common event in cancer. Neoantigens expressed from genes with mutations acquired during carcinogenesis can be tumor-specific. Since the immune system recognizes tumor-specific peptides, they are potential targets for personalized neoantigen-based immunotherapy. However, the discovery of druggable neoantigens remains challenging, suggesting that a deeper understanding of the mechanism of neoantigen generation and better strategies to identify them will be required to realize the promise of neoantigen-based immunotherapy. Alternative splicing and RNA editing events are emerging mechanisms leading to neoantigen production. In this review, we outline recent work involving the large-scale screening of neoantigens produced by alternative splicing and RNA editing. We also describe strategies to predict and validate neoantigens from RNA sequencing data.http://genominfo.org/upload/pdf/gi-2019-17-3-e23.pdfalternative splicingneoantigenRNA editing |
| spellingShingle | Jiyeon Park Yeun-Jun Chung Identification of neoantigens derived from alternative splicing and RNA modification Genomics & Informatics alternative splicing neoantigen RNA editing |
| title | Identification of neoantigens derived from alternative splicing and RNA modification |
| title_full | Identification of neoantigens derived from alternative splicing and RNA modification |
| title_fullStr | Identification of neoantigens derived from alternative splicing and RNA modification |
| title_full_unstemmed | Identification of neoantigens derived from alternative splicing and RNA modification |
| title_short | Identification of neoantigens derived from alternative splicing and RNA modification |
| title_sort | identification of neoantigens derived from alternative splicing and rna modification |
| topic | alternative splicing neoantigen RNA editing |
| url | http://genominfo.org/upload/pdf/gi-2019-17-3-e23.pdf |
| work_keys_str_mv | AT jiyeonpark identificationofneoantigensderivedfromalternativesplicingandrnamodification AT yeunjunchung identificationofneoantigensderivedfromalternativesplicingandrnamodification |