Targeting PDGF/PDGFR Signaling Pathway by microRNA, lncRNA, and circRNA for Therapy of Vascular Diseases: A Narrow Review
Despite the significant progress in diagnostic and therapeutic strategies, vascular diseases, such as cardiovascular diseases (CVDs) and respiratory diseases, still cannot be successfully eliminated. Vascular cells play a key role in maintaining vascular homeostasis. Notably, a variety of cells prod...
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MDPI AG
2024-11-01
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| author | Chao-Nan Ma Shan-Rui Shi Xue-Ying Zhang Guo-Song Xin Xiang Zou Wen-Lan Li Shou-Dong Guo |
| author_facet | Chao-Nan Ma Shan-Rui Shi Xue-Ying Zhang Guo-Song Xin Xiang Zou Wen-Lan Li Shou-Dong Guo |
| author_sort | Chao-Nan Ma |
| collection | DOAJ |
| description | Despite the significant progress in diagnostic and therapeutic strategies, vascular diseases, such as cardiovascular diseases (CVDs) and respiratory diseases, still cannot be successfully eliminated. Vascular cells play a key role in maintaining vascular homeostasis. Notably, a variety of cells produce and secrete platelet-derived growth factors (PDGFs), which promote mitosis and induce the division, proliferation, and migration of vascular cells including vascular smooth muscle cells (SMCs), aortic SMCs, endothelial cells, and airway SMCs. Therefore, PDGF/PDGR receptor signaling pathways play vital roles in regulating the homeostasis of blood vessels and the onset and development of CVDs, such as atherosclerosis, and respiratory diseases including asthma and pulmonary arterial hypertension. Recently, accumulating evidence has demonstrated that microRNA, long-chain non-coding RNA, and circular RNA are involved in the regulation of PDGF/PDGFR signaling pathways through competitive interactions with target mRNAs, contributing to the occurrence and development of the above-mentioned diseases. These novel findings are useful for laboratory research and clinical studies. The aim of this article is to conclude the recent progresses in this field, particular the mechanisms of action of these non-coding RNAs in regulating vascular remodeling, providing potential strategies for the diagnosis, prevention, and treatment of vascular-dysfunction-related diseases, particularly CVDs and respiratory diseases. |
| format | Article |
| id | doaj-art-b7cf1b9874384f5db884710883a8ee2b |
| institution | OA Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-b7cf1b9874384f5db884710883a8ee2b2025-08-20T02:08:02ZengMDPI AGBiomolecules2218-273X2024-11-011411144610.3390/biom14111446Targeting PDGF/PDGFR Signaling Pathway by microRNA, lncRNA, and circRNA for Therapy of Vascular Diseases: A Narrow ReviewChao-Nan Ma0Shan-Rui Shi1Xue-Ying Zhang2Guo-Song Xin3Xiang Zou4Wen-Lan Li5Shou-Dong Guo6Institute of Lipid Metabolism and Atherosclerosis, School of Pharmacy, Shandong Second Medical University, Weifang 261053, ChinaInstitute of Lipid Metabolism and Atherosclerosis, School of Pharmacy, Shandong Second Medical University, Weifang 261053, ChinaInstitute of Lipid Metabolism and Atherosclerosis, School of Pharmacy, Shandong Second Medical University, Weifang 261053, ChinaSchool of Pharmacy, Engineering Research Center for Medicine, Harbin University of Commerce, Harbin 150076, ChinaSchool of Pharmacy, Engineering Research Center for Medicine, Harbin University of Commerce, Harbin 150076, ChinaSchool of Pharmacy, Engineering Research Center for Medicine, Harbin University of Commerce, Harbin 150076, ChinaInstitute of Lipid Metabolism and Atherosclerosis, School of Pharmacy, Shandong Second Medical University, Weifang 261053, ChinaDespite the significant progress in diagnostic and therapeutic strategies, vascular diseases, such as cardiovascular diseases (CVDs) and respiratory diseases, still cannot be successfully eliminated. Vascular cells play a key role in maintaining vascular homeostasis. Notably, a variety of cells produce and secrete platelet-derived growth factors (PDGFs), which promote mitosis and induce the division, proliferation, and migration of vascular cells including vascular smooth muscle cells (SMCs), aortic SMCs, endothelial cells, and airway SMCs. Therefore, PDGF/PDGR receptor signaling pathways play vital roles in regulating the homeostasis of blood vessels and the onset and development of CVDs, such as atherosclerosis, and respiratory diseases including asthma and pulmonary arterial hypertension. Recently, accumulating evidence has demonstrated that microRNA, long-chain non-coding RNA, and circular RNA are involved in the regulation of PDGF/PDGFR signaling pathways through competitive interactions with target mRNAs, contributing to the occurrence and development of the above-mentioned diseases. These novel findings are useful for laboratory research and clinical studies. The aim of this article is to conclude the recent progresses in this field, particular the mechanisms of action of these non-coding RNAs in regulating vascular remodeling, providing potential strategies for the diagnosis, prevention, and treatment of vascular-dysfunction-related diseases, particularly CVDs and respiratory diseases.https://www.mdpi.com/2218-273X/14/11/1446cardiovascular diseasenon-coding RNAplatelet-derived growth factorrespiratory diseasevascular system |
| spellingShingle | Chao-Nan Ma Shan-Rui Shi Xue-Ying Zhang Guo-Song Xin Xiang Zou Wen-Lan Li Shou-Dong Guo Targeting PDGF/PDGFR Signaling Pathway by microRNA, lncRNA, and circRNA for Therapy of Vascular Diseases: A Narrow Review Biomolecules cardiovascular disease non-coding RNA platelet-derived growth factor respiratory disease vascular system |
| title | Targeting PDGF/PDGFR Signaling Pathway by microRNA, lncRNA, and circRNA for Therapy of Vascular Diseases: A Narrow Review |
| title_full | Targeting PDGF/PDGFR Signaling Pathway by microRNA, lncRNA, and circRNA for Therapy of Vascular Diseases: A Narrow Review |
| title_fullStr | Targeting PDGF/PDGFR Signaling Pathway by microRNA, lncRNA, and circRNA for Therapy of Vascular Diseases: A Narrow Review |
| title_full_unstemmed | Targeting PDGF/PDGFR Signaling Pathway by microRNA, lncRNA, and circRNA for Therapy of Vascular Diseases: A Narrow Review |
| title_short | Targeting PDGF/PDGFR Signaling Pathway by microRNA, lncRNA, and circRNA for Therapy of Vascular Diseases: A Narrow Review |
| title_sort | targeting pdgf pdgfr signaling pathway by microrna lncrna and circrna for therapy of vascular diseases a narrow review |
| topic | cardiovascular disease non-coding RNA platelet-derived growth factor respiratory disease vascular system |
| url | https://www.mdpi.com/2218-273X/14/11/1446 |
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