Force of Infection Model for Estimating Time to Dengue Virus Seropositivity among Expatriate Populations, Thailand

Dengue is a major cause of illness among local populations and travelers in dengue-endemic areas, particularly those who stay for an extended period. However, little is known about dengue risk among expatriates and other long-term travelers. We used catalytic models of force of infection to estimat...

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Main Authors: Erica Rapheal, Amornphat Kitro, Hisham Imad, Marco Hamins-Peurtolas, Jutarmas Olanwijitwong, Lapakorn Chatapat, Taweewun Hunsawong, Kathryn Anderson, Watcharapong Piyaphanee
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2025-06-01
Series:Emerging Infectious Diseases
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Online Access:https://wwwnc.cdc.gov/eid/article/31/6/24-1686_article
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author Erica Rapheal
Amornphat Kitro
Hisham Imad
Marco Hamins-Peurtolas
Jutarmas Olanwijitwong
Lapakorn Chatapat
Taweewun Hunsawong
Kathryn Anderson
Watcharapong Piyaphanee
author_facet Erica Rapheal
Amornphat Kitro
Hisham Imad
Marco Hamins-Peurtolas
Jutarmas Olanwijitwong
Lapakorn Chatapat
Taweewun Hunsawong
Kathryn Anderson
Watcharapong Piyaphanee
author_sort Erica Rapheal
collection DOAJ
description Dengue is a major cause of illness among local populations and travelers in dengue-endemic areas, particularly those who stay for an extended period. However, little is known about dengue risk among expatriates and other long-term travelers. We used catalytic models of force of infection to estimate time to 60% dengue virus (DENV) seropositivity for a cross-section of expatriates living in Bangkok and Pattaya, Thailand. Our model adjusted for daily time spent outside, years not exposed to DENV, sex, living environment, and use of mosquito repellent, nets, long sleeves, and air conditioning. We estimated an adjusted annual force of infection of 0.014 (95% CI 0.003–0.054) per year spent in dengue-endemic areas (67.3 years to 60% seropositivity), below that of local populations. Our findings suggest that expatriates have a DENV exposure profile distinct from locals and short-term travelers and should likely be considered independently when developing vaccine and prevention recommendations.
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issn 1080-6040
1080-6059
language English
publishDate 2025-06-01
publisher Centers for Disease Control and Prevention
record_format Article
series Emerging Infectious Diseases
spelling doaj-art-b7ca84e158cc4a9fbda8dd5ae225b7a12025-08-20T03:21:42ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592025-06-013161149115710.3201/eid3106.241686Force of Infection Model for Estimating Time to Dengue Virus Seropositivity among Expatriate Populations, ThailandErica RaphealAmornphat KitroHisham ImadMarco Hamins-PeurtolasJutarmas OlanwijitwongLapakorn ChatapatTaweewun HunsawongKathryn AndersonWatcharapong Piyaphanee Dengue is a major cause of illness among local populations and travelers in dengue-endemic areas, particularly those who stay for an extended period. However, little is known about dengue risk among expatriates and other long-term travelers. We used catalytic models of force of infection to estimate time to 60% dengue virus (DENV) seropositivity for a cross-section of expatriates living in Bangkok and Pattaya, Thailand. Our model adjusted for daily time spent outside, years not exposed to DENV, sex, living environment, and use of mosquito repellent, nets, long sleeves, and air conditioning. We estimated an adjusted annual force of infection of 0.014 (95% CI 0.003–0.054) per year spent in dengue-endemic areas (67.3 years to 60% seropositivity), below that of local populations. Our findings suggest that expatriates have a DENV exposure profile distinct from locals and short-term travelers and should likely be considered independently when developing vaccine and prevention recommendations. https://wwwnc.cdc.gov/eid/article/31/6/24-1686_articledenguevirusesvector-borne infectionstravel medicinevaccinesarboviruses
spellingShingle Erica Rapheal
Amornphat Kitro
Hisham Imad
Marco Hamins-Peurtolas
Jutarmas Olanwijitwong
Lapakorn Chatapat
Taweewun Hunsawong
Kathryn Anderson
Watcharapong Piyaphanee
Force of Infection Model for Estimating Time to Dengue Virus Seropositivity among Expatriate Populations, Thailand
Emerging Infectious Diseases
dengue
viruses
vector-borne infections
travel medicine
vaccines
arboviruses
title Force of Infection Model for Estimating Time to Dengue Virus Seropositivity among Expatriate Populations, Thailand
title_full Force of Infection Model for Estimating Time to Dengue Virus Seropositivity among Expatriate Populations, Thailand
title_fullStr Force of Infection Model for Estimating Time to Dengue Virus Seropositivity among Expatriate Populations, Thailand
title_full_unstemmed Force of Infection Model for Estimating Time to Dengue Virus Seropositivity among Expatriate Populations, Thailand
title_short Force of Infection Model for Estimating Time to Dengue Virus Seropositivity among Expatriate Populations, Thailand
title_sort force of infection model for estimating time to dengue virus seropositivity among expatriate populations thailand
topic dengue
viruses
vector-borne infections
travel medicine
vaccines
arboviruses
url https://wwwnc.cdc.gov/eid/article/31/6/24-1686_article
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