Investigations of the antioxidants, antidiabetics and antiviral potential against SARS-CoV-2 of gold functionalized carboxymethyl cellulose
A composite of gold and carboxymethyl cellulose (Au-CMC) was prepared from gold(III) chloride and the sodium salt of carboxymethyl cellulose. The prepared composite was characterized by using x-ray diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier-...
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IOP Publishing
2025-01-01
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| Series: | Materials Research Express |
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| Online Access: | https://doi.org/10.1088/2053-1591/ade7d3 |
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| author | Timothy O Ajiboye Kolawole A Olofinsan Nanabi Manamela Matsabisa G Motlalepula Modupe O Ogunrombi Subhendu Dhibar Frank Eric T Foka Hazel T Mufhandu E Erasmus H G Visser M Schutte-Smith |
| author_facet | Timothy O Ajiboye Kolawole A Olofinsan Nanabi Manamela Matsabisa G Motlalepula Modupe O Ogunrombi Subhendu Dhibar Frank Eric T Foka Hazel T Mufhandu E Erasmus H G Visser M Schutte-Smith |
| author_sort | Timothy O Ajiboye |
| collection | DOAJ |
| description | A composite of gold and carboxymethyl cellulose (Au-CMC) was prepared from gold(III) chloride and the sodium salt of carboxymethyl cellulose. The prepared composite was characterized by using x-ray diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and Energy-dispersive x-ray spectroscopy (EDX). Then, ferric reducing, nitric oxide scavenging and free radical scavenging activities of the synthesized Au-CMC were carried out. In addition, inhibitory activities of the material against α -amylase, α -glucosidase enzymes and SARS-CoV-2 were studied. It was found that the material displayed good antioxidant activities. Especially, its NO scavenging activities was higher than that of vanillin, gold nanoparticles and carboxymethyl cellulose alone. The α -glucosidase enzyme inhibitory effect of the material was better than that of acarbose. Findings also revealed that both CMC and Au-CMC are highly potent against B1.351 and BQ.1.1 variants of SARS-CoV-2. Finally, cytotoxicity studies showed that the two compounds can be used safely in biomedical applications, such as drug delivery, tissue engineering, or as stabilizers in formulations, without concerns. |
| format | Article |
| id | doaj-art-b7c8c7eb90f54da28fd9fdfea858856c |
| institution | OA Journals |
| issn | 2053-1591 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | Materials Research Express |
| spelling | doaj-art-b7c8c7eb90f54da28fd9fdfea858856c2025-08-20T02:37:38ZengIOP PublishingMaterials Research Express2053-15912025-01-0112707540110.1088/2053-1591/ade7d3Investigations of the antioxidants, antidiabetics and antiviral potential against SARS-CoV-2 of gold functionalized carboxymethyl celluloseTimothy O Ajiboye0https://orcid.org/0000-0001-5418-3234Kolawole A Olofinsan1https://orcid.org/0000-0002-2987-0996Nanabi Manamela2https://orcid.org/0000-0002-6958-9787Matsabisa G Motlalepula3Modupe O Ogunrombi4Subhendu Dhibar5Frank Eric T Foka6Hazel T Mufhandu7https://orcid.org/0000-0002-1551-3314E Erasmus8https://orcid.org/0000-0003-0546-697XH G Visser9https://orcid.org/0000-0002-1719-1232M Schutte-Smith10Department of Chemistry, University of the Free State , Bloemfontein, 9300, South AfricaDepartment of Pharmacology, Faculty of Health Sciences, University of the Free State , Bloemfontein 9300, South AfricaDepartment of Microbiology, Virology Laboratory, School of Biological Sciences, Faculty of Natural and Agricultural Sciences, North-West University , Mafikeng, Private Bag, Mmabatho X2046, South AfricaDepartment of Pharmacology, Faculty of Health Sciences, University of the Free State , Bloemfontein 9300, South AfricaDepartment of Clinical Pharmacology and Therapeutics, Sefako Makgatho Health Sciences University , Pretoria, South AfricaColloid Chemistry Laboratory, Department of Chemistry, The University of Burdwan , Golapbag, Burdwan 713104, West Bengal, IndiaDepartment of Microbiology, Virology Laboratory, School of Biological Sciences, Faculty of Natural and Agricultural Sciences, North-West University , Mafikeng, Private Bag, Mmabatho X2046, South AfricaDepartment of Microbiology, Virology Laboratory, School of Biological Sciences, Faculty of Natural and Agricultural Sciences, North-West University , Mafikeng, Private Bag, Mmabatho X2046, South AfricaDepartment of Chemistry, University of the Free State , Bloemfontein, 9300, South AfricaDepartment of Chemistry, University of the Free State , Bloemfontein, 9300, South AfricaDepartment of Chemistry, University of the Free State , Bloemfontein, 9300, South AfricaA composite of gold and carboxymethyl cellulose (Au-CMC) was prepared from gold(III) chloride and the sodium salt of carboxymethyl cellulose. The prepared composite was characterized by using x-ray diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and Energy-dispersive x-ray spectroscopy (EDX). Then, ferric reducing, nitric oxide scavenging and free radical scavenging activities of the synthesized Au-CMC were carried out. In addition, inhibitory activities of the material against α -amylase, α -glucosidase enzymes and SARS-CoV-2 were studied. It was found that the material displayed good antioxidant activities. Especially, its NO scavenging activities was higher than that of vanillin, gold nanoparticles and carboxymethyl cellulose alone. The α -glucosidase enzyme inhibitory effect of the material was better than that of acarbose. Findings also revealed that both CMC and Au-CMC are highly potent against B1.351 and BQ.1.1 variants of SARS-CoV-2. Finally, cytotoxicity studies showed that the two compounds can be used safely in biomedical applications, such as drug delivery, tissue engineering, or as stabilizers in formulations, without concerns.https://doi.org/10.1088/2053-1591/ade7d3gold-carbon compositeantiviralantidiabeticsantioxidantscytotoxicity |
| spellingShingle | Timothy O Ajiboye Kolawole A Olofinsan Nanabi Manamela Matsabisa G Motlalepula Modupe O Ogunrombi Subhendu Dhibar Frank Eric T Foka Hazel T Mufhandu E Erasmus H G Visser M Schutte-Smith Investigations of the antioxidants, antidiabetics and antiviral potential against SARS-CoV-2 of gold functionalized carboxymethyl cellulose Materials Research Express gold-carbon composite antiviral antidiabetics antioxidants cytotoxicity |
| title | Investigations of the antioxidants, antidiabetics and antiviral potential against SARS-CoV-2 of gold functionalized carboxymethyl cellulose |
| title_full | Investigations of the antioxidants, antidiabetics and antiviral potential against SARS-CoV-2 of gold functionalized carboxymethyl cellulose |
| title_fullStr | Investigations of the antioxidants, antidiabetics and antiviral potential against SARS-CoV-2 of gold functionalized carboxymethyl cellulose |
| title_full_unstemmed | Investigations of the antioxidants, antidiabetics and antiviral potential against SARS-CoV-2 of gold functionalized carboxymethyl cellulose |
| title_short | Investigations of the antioxidants, antidiabetics and antiviral potential against SARS-CoV-2 of gold functionalized carboxymethyl cellulose |
| title_sort | investigations of the antioxidants antidiabetics and antiviral potential against sars cov 2 of gold functionalized carboxymethyl cellulose |
| topic | gold-carbon composite antiviral antidiabetics antioxidants cytotoxicity |
| url | https://doi.org/10.1088/2053-1591/ade7d3 |
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