Topical Curcumin-Based Cream Is Equivalent to Dietary Curcumin in a Skin Cancer Model
Skin squamous cell carcinoma (SCC), the most common cancer in the USA, is a growing problem with the use of tanning booths causing sun-damaged skin. Antiproliferative effects of curcumin were demonstrated in an aggressive skin cancer cell line SRB12-p9 (P<0.05 compared to control). Topical formul...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Skin Cancer |
| Online Access: | http://dx.doi.org/10.1155/2012/147863 |
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| author | Kunal Sonavane Jeffrey Phillips Oleksandr Ekshyyan Tara Moore-Medlin Jennifer Roberts Gill Xiaohua Rong Raghunatha Reddy Lakshmaiah Fleurette Abreo Douglas Boudreaux John L. Clifford Cherie-Ann O. Nathan |
| author_facet | Kunal Sonavane Jeffrey Phillips Oleksandr Ekshyyan Tara Moore-Medlin Jennifer Roberts Gill Xiaohua Rong Raghunatha Reddy Lakshmaiah Fleurette Abreo Douglas Boudreaux John L. Clifford Cherie-Ann O. Nathan |
| author_sort | Kunal Sonavane |
| collection | DOAJ |
| description | Skin squamous cell carcinoma (SCC), the most common cancer in the USA, is a growing problem with the use of tanning booths causing sun-damaged skin. Antiproliferative effects of curcumin were demonstrated in an aggressive skin cancer cell line SRB12-p9 (P<0.05 compared to control). Topical formulation was as effective as oral curcumin at suppressing tumor growth in a mouse skin cancer model. Curcumin at 15 mg administered by oral, topical, or combined formulation significantly reduced tumor growth compared to control (P=0.004). Inhibition of pAKT, pS6, p-4EBP1, pSTAT3, and pERK1/2 was noted in SRB12-p9 cells post-curcumin treatment compared to control (P<0.05). Inhibition of pSTAT3 and pERK1/2 was also noted in curcumin-treated groups in vivo. IHC analysis revealed human tumor specimens that expressed significantly more activated pERK (P=0.006) and pS6 (P<0.0001) than normal skin samples. This is the first study to compare topical curcumin to oral curcumin. Our data supports the use of curcumin as a chemopreventive for skin SCC where condemned skin is a significant problem. Prevention strategies offer the best hope of future health care costs in a disease that is increasing in incidence due to increased sun exposure. |
| format | Article |
| id | doaj-art-b7c7af470d99487c9ab7dab4144dc006 |
| institution | DOAJ |
| issn | 2090-2905 2090-2913 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Skin Cancer |
| spelling | doaj-art-b7c7af470d99487c9ab7dab4144dc0062025-08-20T03:22:46ZengWileyJournal of Skin Cancer2090-29052090-29132012-01-01201210.1155/2012/147863147863Topical Curcumin-Based Cream Is Equivalent to Dietary Curcumin in a Skin Cancer ModelKunal Sonavane0Jeffrey Phillips1Oleksandr Ekshyyan2Tara Moore-Medlin3Jennifer Roberts Gill4Xiaohua Rong5Raghunatha Reddy Lakshmaiah6Fleurette Abreo7Douglas Boudreaux8John L. Clifford9Cherie-Ann O. Nathan10Department of Otolaryngology-Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USADepartment of Otolaryngology-Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USADepartment of Otolaryngology-Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USADepartment of Otolaryngology-Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USADepartment of Biochemistry, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USADepartment of Otolaryngology-Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USADepartment of Otolaryngology-Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USADepartment of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USABoudreaux’s Compounding Pharmacy, Shreveport, LA 71130-3932, USADepartment of Biochemistry, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USADepartment of Otolaryngology-Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA 71130-3932, USASkin squamous cell carcinoma (SCC), the most common cancer in the USA, is a growing problem with the use of tanning booths causing sun-damaged skin. Antiproliferative effects of curcumin were demonstrated in an aggressive skin cancer cell line SRB12-p9 (P<0.05 compared to control). Topical formulation was as effective as oral curcumin at suppressing tumor growth in a mouse skin cancer model. Curcumin at 15 mg administered by oral, topical, or combined formulation significantly reduced tumor growth compared to control (P=0.004). Inhibition of pAKT, pS6, p-4EBP1, pSTAT3, and pERK1/2 was noted in SRB12-p9 cells post-curcumin treatment compared to control (P<0.05). Inhibition of pSTAT3 and pERK1/2 was also noted in curcumin-treated groups in vivo. IHC analysis revealed human tumor specimens that expressed significantly more activated pERK (P=0.006) and pS6 (P<0.0001) than normal skin samples. This is the first study to compare topical curcumin to oral curcumin. Our data supports the use of curcumin as a chemopreventive for skin SCC where condemned skin is a significant problem. Prevention strategies offer the best hope of future health care costs in a disease that is increasing in incidence due to increased sun exposure.http://dx.doi.org/10.1155/2012/147863 |
| spellingShingle | Kunal Sonavane Jeffrey Phillips Oleksandr Ekshyyan Tara Moore-Medlin Jennifer Roberts Gill Xiaohua Rong Raghunatha Reddy Lakshmaiah Fleurette Abreo Douglas Boudreaux John L. Clifford Cherie-Ann O. Nathan Topical Curcumin-Based Cream Is Equivalent to Dietary Curcumin in a Skin Cancer Model Journal of Skin Cancer |
| title | Topical Curcumin-Based Cream Is Equivalent to Dietary Curcumin in a Skin Cancer Model |
| title_full | Topical Curcumin-Based Cream Is Equivalent to Dietary Curcumin in a Skin Cancer Model |
| title_fullStr | Topical Curcumin-Based Cream Is Equivalent to Dietary Curcumin in a Skin Cancer Model |
| title_full_unstemmed | Topical Curcumin-Based Cream Is Equivalent to Dietary Curcumin in a Skin Cancer Model |
| title_short | Topical Curcumin-Based Cream Is Equivalent to Dietary Curcumin in a Skin Cancer Model |
| title_sort | topical curcumin based cream is equivalent to dietary curcumin in a skin cancer model |
| url | http://dx.doi.org/10.1155/2012/147863 |
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