Prehabilitation during neoadjuvant therapy in patients with cancer of the upper gastrointestinal tract and rectum—the study protocol
AimsThe concept of prehabilitation, defined as interventions aimed at enhancing a patient's functional capacity prior to an impending physiological stressor, may contribute to reduced postoperative morbidity and mortality. The study's goal is to verify or refute the feasibility of a prehab...
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| Format: | Article |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Sports and Active Living |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fspor.2024.1495398/full |
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| author | Irina Chmelova Irina Chmelova Dalibor Pastucha Dalibor Pastucha Tomas Hudecek Zdenek Guran Zdenek Guran Sona Ciecotkova Lubomír Martínek Jana Zubikova Alena Matlova Jakub Dolezel Dana Salounova Jakub Chmelo |
| author_facet | Irina Chmelova Irina Chmelova Dalibor Pastucha Dalibor Pastucha Tomas Hudecek Zdenek Guran Zdenek Guran Sona Ciecotkova Lubomír Martínek Jana Zubikova Alena Matlova Jakub Dolezel Dana Salounova Jakub Chmelo |
| author_sort | Irina Chmelova |
| collection | DOAJ |
| description | AimsThe concept of prehabilitation, defined as interventions aimed at enhancing a patient's functional capacity prior to an impending physiological stressor, may contribute to reduced postoperative morbidity and mortality. The study's goal is to verify or refute the feasibility of a prehabilitation programme for two diagnostic patient groups during neoadjuvant chemo(radio)therapy, which is prescribed before the scheduled surgical procedure. This is a single group study design, with all patients enrolled receiving the intervention.MethodsThis is an interventional feasibility study of a prehabilitation programme in the form of physical training conducted at home. The training consists of progressively dosed walking and strength exercises for selected muscle groups. Data will be monitored telemetrically and also through telephone contact with participants. Primary outcomes include: the percentage of patients interested in participating in the study out of all patients indicated for neoadjuvant therapy at University Hospital Ostrava during the observed period, the percentage of patients who complete the prehabilitation programme until the date of surgery and individual patient compliance. Secondary outcomes include physical fitness parameters obtained from cardiopulmonary exercise testing, grip strength measured by a dynamometer, changes in body composition, EORTC QLQ-C30 quality of life questionnaire, and a questionnaire on the subjective perception of the exercise programme. Both primary and secondary outcomes will be compared between study arms (two diagnostic groups). The study is registered at ClinicalTrials.gov, ID: NCT05646043.ConclusionThe results of this study can serve as a foundation for larger, multicentre, controlled studies in the future. |
| format | Article |
| id | doaj-art-b7c761733aca4295878f86083331a746 |
| institution | Kabale University |
| issn | 2624-9367 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Sports and Active Living |
| spelling | doaj-art-b7c761733aca4295878f86083331a7462025-02-03T06:33:30ZengFrontiers Media S.A.Frontiers in Sports and Active Living2624-93672025-02-01610.3389/fspor.2024.14953981495398Prehabilitation during neoadjuvant therapy in patients with cancer of the upper gastrointestinal tract and rectum—the study protocolIrina Chmelova0Irina Chmelova1Dalibor Pastucha2Dalibor Pastucha3Tomas Hudecek4Zdenek Guran5Zdenek Guran6Sona Ciecotkova7Lubomír Martínek8Jana Zubikova9Alena Matlova10Jakub Dolezel11Dana Salounova12Jakub Chmelo13Department of Rehabilitation and Sports Medicine, University Hospital Ostrava, Ostrava, CzechiaDepartment of Rehabilitation and Sports Medicine, Faculty of Medicine, University of Ostrava, Ostrava, CzechiaDepartment of Rehabilitation and Sports Medicine, University Hospital Ostrava, Ostrava, CzechiaDepartment of Rehabilitation and Sports Medicine, Faculty of Medicine, University of Ostrava, Ostrava, CzechiaDepartment of Rehabilitation and Sports Medicine, University Hospital Ostrava, Ostrava, CzechiaDepartment of Rehabilitation and Sports Medicine, University Hospital Ostrava, Ostrava, CzechiaDepartment of Rehabilitation and Sports Medicine, Faculty of Medicine, University of Ostrava, Ostrava, CzechiaDepartment of Rehabilitation and Sports Medicine, University Hospital Ostrava, Ostrava, CzechiaDepartment of Surgery, University Hospital Ostrava, Ostrava, CzechiaDepartment of Oncology, University Hospital Ostrava and Faculty of Medicine, University of Ostrava, Ostrava, CzechiaDepartment of Anesthesiology, Resuscitation and Intensive Care Medicine, University Hospital Ostrava, Ostrava, CzechiaCentre for Telemedicine Services, University Hospital Ostrava, Ostrava, CzechiaCentre for Health Research, Faculty of Medicine, University of Ostrava, Ostrava, CzechiaNorthern Oesophagogastric Unit, Royal Victoria Infirmary, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, United KingdomAimsThe concept of prehabilitation, defined as interventions aimed at enhancing a patient's functional capacity prior to an impending physiological stressor, may contribute to reduced postoperative morbidity and mortality. The study's goal is to verify or refute the feasibility of a prehabilitation programme for two diagnostic patient groups during neoadjuvant chemo(radio)therapy, which is prescribed before the scheduled surgical procedure. This is a single group study design, with all patients enrolled receiving the intervention.MethodsThis is an interventional feasibility study of a prehabilitation programme in the form of physical training conducted at home. The training consists of progressively dosed walking and strength exercises for selected muscle groups. Data will be monitored telemetrically and also through telephone contact with participants. Primary outcomes include: the percentage of patients interested in participating in the study out of all patients indicated for neoadjuvant therapy at University Hospital Ostrava during the observed period, the percentage of patients who complete the prehabilitation programme until the date of surgery and individual patient compliance. Secondary outcomes include physical fitness parameters obtained from cardiopulmonary exercise testing, grip strength measured by a dynamometer, changes in body composition, EORTC QLQ-C30 quality of life questionnaire, and a questionnaire on the subjective perception of the exercise programme. Both primary and secondary outcomes will be compared between study arms (two diagnostic groups). The study is registered at ClinicalTrials.gov, ID: NCT05646043.ConclusionThe results of this study can serve as a foundation for larger, multicentre, controlled studies in the future.https://www.frontiersin.org/articles/10.3389/fspor.2024.1495398/fullprehabilitationneoadjuvant therapyphysical activitysurgical oncolgoyphysical training |
| spellingShingle | Irina Chmelova Irina Chmelova Dalibor Pastucha Dalibor Pastucha Tomas Hudecek Zdenek Guran Zdenek Guran Sona Ciecotkova Lubomír Martínek Jana Zubikova Alena Matlova Jakub Dolezel Dana Salounova Jakub Chmelo Prehabilitation during neoadjuvant therapy in patients with cancer of the upper gastrointestinal tract and rectum—the study protocol Frontiers in Sports and Active Living prehabilitation neoadjuvant therapy physical activity surgical oncolgoy physical training |
| title | Prehabilitation during neoadjuvant therapy in patients with cancer of the upper gastrointestinal tract and rectum—the study protocol |
| title_full | Prehabilitation during neoadjuvant therapy in patients with cancer of the upper gastrointestinal tract and rectum—the study protocol |
| title_fullStr | Prehabilitation during neoadjuvant therapy in patients with cancer of the upper gastrointestinal tract and rectum—the study protocol |
| title_full_unstemmed | Prehabilitation during neoadjuvant therapy in patients with cancer of the upper gastrointestinal tract and rectum—the study protocol |
| title_short | Prehabilitation during neoadjuvant therapy in patients with cancer of the upper gastrointestinal tract and rectum—the study protocol |
| title_sort | prehabilitation during neoadjuvant therapy in patients with cancer of the upper gastrointestinal tract and rectum the study protocol |
| topic | prehabilitation neoadjuvant therapy physical activity surgical oncolgoy physical training |
| url | https://www.frontiersin.org/articles/10.3389/fspor.2024.1495398/full |
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