Role of Talc Modulation on Cytokine Activation in Cancer Patients Undergoing Pleurodesis
We investigate the mechanism of talc pleurodesis (TP) in 20 patients with recurrent malignant pleural effusion and 10 patients with nonmalignant pleural effusions. We measured IL-8 levels before and 6 h after TP and find a significant threefold increase (2.26 ng/mL ± 0.7 to 6.5 ng/mL 0.1), which exp...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/806183 |
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| author | Yehuda Schwarz Alex Star |
| author_facet | Yehuda Schwarz Alex Star |
| author_sort | Yehuda Schwarz |
| collection | DOAJ |
| description | We investigate the mechanism of talc pleurodesis (TP) in 20 patients with recurrent malignant pleural effusion and 10 patients with nonmalignant pleural effusions. We measured IL-8 levels before and 6 h after TP and find a significant threefold increase (2.26 ng/mL ± 0.7 to 6.5 ng/mL 0.1), which explains the recruitment of inflammatory cells in these patients. We hypothesize that TP is enable by stimulating the mesothelial cells (MS) to secrete FGF. A significant tenfold increase in FGF-b (0.05 ng/mL ± 0.02 to 0.44 ng/mL 0.6) was seen 24 h after talc instillation (𝑃<0.04). In order to examine whether FGF-b is secreted by MS cells, MS recovered from CHF patients with recurrent pleural effusions were cultured for 48 h in the presence or absence of increasing concentrations of talc (from 100 ng/mL to 1 mg/mL). They produced significant levels of FGF-b in a dose dependent manner (𝑃<0.005). We hypothesized that a successful pleurodesis involves an early enhanced recruitment of inflammatory cells through a rise of IL-8 followed by enrollment of fibroblasts from the submesothelial space through increased mesothelial FGF-b production. |
| format | Article |
| id | doaj-art-b7c3b80d4d784dfab1b117abd4182bab |
| institution | DOAJ |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-b7c3b80d4d784dfab1b117abd4182bab2025-08-20T03:22:46ZengWileyPulmonary Medicine2090-18362090-18442012-01-01201210.1155/2012/806183806183Role of Talc Modulation on Cytokine Activation in Cancer Patients Undergoing PleurodesisYehuda Schwarz0Alex Star1Department of Pulmonary Medicine, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv 64239, IsraelDepartment of Pulmonary Medicine, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv 64239, IsraelWe investigate the mechanism of talc pleurodesis (TP) in 20 patients with recurrent malignant pleural effusion and 10 patients with nonmalignant pleural effusions. We measured IL-8 levels before and 6 h after TP and find a significant threefold increase (2.26 ng/mL ± 0.7 to 6.5 ng/mL 0.1), which explains the recruitment of inflammatory cells in these patients. We hypothesize that TP is enable by stimulating the mesothelial cells (MS) to secrete FGF. A significant tenfold increase in FGF-b (0.05 ng/mL ± 0.02 to 0.44 ng/mL 0.6) was seen 24 h after talc instillation (𝑃<0.04). In order to examine whether FGF-b is secreted by MS cells, MS recovered from CHF patients with recurrent pleural effusions were cultured for 48 h in the presence or absence of increasing concentrations of talc (from 100 ng/mL to 1 mg/mL). They produced significant levels of FGF-b in a dose dependent manner (𝑃<0.005). We hypothesized that a successful pleurodesis involves an early enhanced recruitment of inflammatory cells through a rise of IL-8 followed by enrollment of fibroblasts from the submesothelial space through increased mesothelial FGF-b production.http://dx.doi.org/10.1155/2012/806183 |
| spellingShingle | Yehuda Schwarz Alex Star Role of Talc Modulation on Cytokine Activation in Cancer Patients Undergoing Pleurodesis Pulmonary Medicine |
| title | Role of Talc Modulation on Cytokine Activation in Cancer Patients Undergoing Pleurodesis |
| title_full | Role of Talc Modulation on Cytokine Activation in Cancer Patients Undergoing Pleurodesis |
| title_fullStr | Role of Talc Modulation on Cytokine Activation in Cancer Patients Undergoing Pleurodesis |
| title_full_unstemmed | Role of Talc Modulation on Cytokine Activation in Cancer Patients Undergoing Pleurodesis |
| title_short | Role of Talc Modulation on Cytokine Activation in Cancer Patients Undergoing Pleurodesis |
| title_sort | role of talc modulation on cytokine activation in cancer patients undergoing pleurodesis |
| url | http://dx.doi.org/10.1155/2012/806183 |
| work_keys_str_mv | AT yehudaschwarz roleoftalcmodulationoncytokineactivationincancerpatientsundergoingpleurodesis AT alexstar roleoftalcmodulationoncytokineactivationincancerpatientsundergoingpleurodesis |