Neural crosstalk and symptom overlap: The correlation between urinary and intestinal symptoms in patients undergoing colonoscopy
Purpose: Neural crosstalk in the pelvis involves intrinsic communication networks among pelvic structures that direct afferent inputs to converge on neurons, leading to viscerovisceral and somatovisceral reflexes. We aimed to explore the overlap between intestinal and urinary symptoms and their corr...
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| Format: | Article |
| Language: | English |
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Korean Urological Association
2025-05-01
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| Series: | Investigative and Clinical Urology |
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| Online Access: | https://www.icurology.org/pdf/10.4111/icu.20240377 |
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| author | Pedro Henrique P. Costa Paulo Rodrigues Lucas S. Takemura Marina A. Germano Mariane Ellen S. Sales Gustavo A. de Paulo Bianca Bianco Maria Beatriz Lemos Gustavo C. Lemos Arie Carneiro |
| author_facet | Pedro Henrique P. Costa Paulo Rodrigues Lucas S. Takemura Marina A. Germano Mariane Ellen S. Sales Gustavo A. de Paulo Bianca Bianco Maria Beatriz Lemos Gustavo C. Lemos Arie Carneiro |
| author_sort | Pedro Henrique P. Costa |
| collection | DOAJ |
| description | Purpose: Neural crosstalk in the pelvis involves intrinsic communication networks among pelvic structures that direct afferent inputs to converge on neurons, leading to viscerovisceral and somatovisceral reflexes. We aimed to explore the overlap between intestinal and urinary symptoms and their correlations in patients undergoing colonoscopy.
Materials and Methods: Cross-sectional study with 167 participants who underwent colonoscopy and were assessed using three self-administered questionnaires: the International Prostate Symptom Score (IPSS) for lower urinary tract symptoms, the International Consultation on Incontinence Questionnaire Overactive Bladder (ICIQ-OAB) for overactive bladder symptoms, and the Gastrointestinal Symptom Rating Scale (GSRS) for gastrointestinal (GI) symptoms.
Results: Among the participants, 55.1% were male, and the median age was 57 years. Most colonoscopies (80.8%) were performed for screening, and the most common finding was diverticular disease (DD) (35.9%). The IPSS and ICIQ-OAB were strongly correlated (rho=0.544, p<0.001), while the IPSS and GSRS scores showed a moderate correlation (rho=0.304, p<0.001). In the DD subgroup, both ICIQ-OAB and IPSS (rho=0.568, p<0.001), and IPSS and GSRS (rho=0.493, p<0.001) showed strong correlations. In contrast, the subgroup without DD showed a strong correlation between the ICIQ-OAB and IPSS (rho=0.510, p<0.001), but only a weak correlation between the IPSS and GSRS (rho=0.188, p=0.057), suggesting that the urinary-GI connection is influenced by the presence of DD.
Conclusions: The findings revealed intrinsic relationships between urinary and GI symptoms, with DD as a significant factor influencing these relationships, suggesting that a more integrated approach to evaluate and manage these patients can potentially improve diagnostic accuracy and treatment outcomes. |
| format | Article |
| id | doaj-art-b7c31bc792eb4e14a629d522fe7903a0 |
| institution | Kabale University |
| issn | 2466-0493 2466-054X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Korean Urological Association |
| record_format | Article |
| series | Investigative and Clinical Urology |
| spelling | doaj-art-b7c31bc792eb4e14a629d522fe7903a02025-08-20T03:53:12ZengKorean Urological AssociationInvestigative and Clinical Urology2466-04932466-054X2025-05-0166325126010.4111/icu.20240377Neural crosstalk and symptom overlap: The correlation between urinary and intestinal symptoms in patients undergoing colonoscopyPedro Henrique P. Costa0https://orcid.org/0009-0009-1326-843XPaulo Rodrigues1https://orcid.org/0000-0002-7397-5277Lucas S. Takemura2https://orcid.org/0000-0001-6683-5797Marina A. Germano3https://orcid.org/0009-0004-0897-7411Mariane Ellen S. Sales4https://orcid.org/0009-0008-3809-2736Gustavo A. de Paulo5https://orcid.org/0000-0002-7926-9373Bianca Bianco6https://orcid.org/0000-0001-8669-3562Maria Beatriz Lemos7https://orcid.org/0009-0001-2285-5136Gustavo C. Lemos8https://orcid.org/0000-0001-8818-4964Arie Carneiro9https://orcid.org/0000-0002-0152-0513Department of Urology, Hospital Israelita Albert Einstein, São Paulo, Brazil.Department of Urology, Hospital Israelita Albert Einstein, São Paulo, Brazil.Department of Urology, Hospital Israelita Albert Einstein, São Paulo, Brazil.Faculdade Israelita de Ciências da Saúde Albert Einstein (FICSAE), São Paulo, Brazil.Faculdade Israelita de Ciências da Saúde Albert Einstein (FICSAE), São Paulo, Brazil.Department of Urology, Hospital Israelita Albert Einstein, São Paulo, Brazil.Department of Urology, Hospital Israelita Albert Einstein, São Paulo, Brazil.Department of Urology, Hospital Israelita Albert Einstein, São Paulo, Brazil.Department of Urology, Hospital Israelita Albert Einstein, São Paulo, Brazil.Department of Urology, Hospital Israelita Albert Einstein, São Paulo, Brazil.Purpose: Neural crosstalk in the pelvis involves intrinsic communication networks among pelvic structures that direct afferent inputs to converge on neurons, leading to viscerovisceral and somatovisceral reflexes. We aimed to explore the overlap between intestinal and urinary symptoms and their correlations in patients undergoing colonoscopy. Materials and Methods: Cross-sectional study with 167 participants who underwent colonoscopy and were assessed using three self-administered questionnaires: the International Prostate Symptom Score (IPSS) for lower urinary tract symptoms, the International Consultation on Incontinence Questionnaire Overactive Bladder (ICIQ-OAB) for overactive bladder symptoms, and the Gastrointestinal Symptom Rating Scale (GSRS) for gastrointestinal (GI) symptoms. Results: Among the participants, 55.1% were male, and the median age was 57 years. Most colonoscopies (80.8%) were performed for screening, and the most common finding was diverticular disease (DD) (35.9%). The IPSS and ICIQ-OAB were strongly correlated (rho=0.544, p<0.001), while the IPSS and GSRS scores showed a moderate correlation (rho=0.304, p<0.001). In the DD subgroup, both ICIQ-OAB and IPSS (rho=0.568, p<0.001), and IPSS and GSRS (rho=0.493, p<0.001) showed strong correlations. In contrast, the subgroup without DD showed a strong correlation between the ICIQ-OAB and IPSS (rho=0.510, p<0.001), but only a weak correlation between the IPSS and GSRS (rho=0.188, p=0.057), suggesting that the urinary-GI connection is influenced by the presence of DD. Conclusions: The findings revealed intrinsic relationships between urinary and GI symptoms, with DD as a significant factor influencing these relationships, suggesting that a more integrated approach to evaluate and manage these patients can potentially improve diagnostic accuracy and treatment outcomes.https://www.icurology.org/pdf/10.4111/icu.20240377diverticular diseaseslower gastrointestinal tractlower urinary tract symptomspelvic painurinary incontinence |
| spellingShingle | Pedro Henrique P. Costa Paulo Rodrigues Lucas S. Takemura Marina A. Germano Mariane Ellen S. Sales Gustavo A. de Paulo Bianca Bianco Maria Beatriz Lemos Gustavo C. Lemos Arie Carneiro Neural crosstalk and symptom overlap: The correlation between urinary and intestinal symptoms in patients undergoing colonoscopy Investigative and Clinical Urology diverticular diseases lower gastrointestinal tract lower urinary tract symptoms pelvic pain urinary incontinence |
| title | Neural crosstalk and symptom overlap: The correlation between urinary and intestinal symptoms in patients undergoing colonoscopy |
| title_full | Neural crosstalk and symptom overlap: The correlation between urinary and intestinal symptoms in patients undergoing colonoscopy |
| title_fullStr | Neural crosstalk and symptom overlap: The correlation between urinary and intestinal symptoms in patients undergoing colonoscopy |
| title_full_unstemmed | Neural crosstalk and symptom overlap: The correlation between urinary and intestinal symptoms in patients undergoing colonoscopy |
| title_short | Neural crosstalk and symptom overlap: The correlation between urinary and intestinal symptoms in patients undergoing colonoscopy |
| title_sort | neural crosstalk and symptom overlap the correlation between urinary and intestinal symptoms in patients undergoing colonoscopy |
| topic | diverticular diseases lower gastrointestinal tract lower urinary tract symptoms pelvic pain urinary incontinence |
| url | https://www.icurology.org/pdf/10.4111/icu.20240377 |
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