Elevated MPV: A Key Indicator of Acute Anterior Circulation Stroke Prognosis in Mechanical Thrombectomy
Shi-Yuan Tian,1 Min-Jie Yu,2 Kefu Mei,1 Bing Xu,1 Lian-Chen Xiao,1 Hong-Bin Wen,1 Fu-Rong Shang1 1Department of Neurology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, People’s Republic of China; 2School of Medicine, Wuhan University of...
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Dove Medical Press
2025-05-01
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| Series: | Therapeutics and Clinical Risk Management |
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| author | Tian SY Yu MJ Mei K Xu B Xiao LC Wen HB Shang FR |
| author_facet | Tian SY Yu MJ Mei K Xu B Xiao LC Wen HB Shang FR |
| author_sort | Tian SY |
| collection | DOAJ |
| description | Shi-Yuan Tian,1 Min-Jie Yu,2 Kefu Mei,1 Bing Xu,1 Lian-Chen Xiao,1 Hong-Bin Wen,1 Fu-Rong Shang1 1Department of Neurology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, People’s Republic of China; 2School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, People’s Republic of ChinaCorrespondence: Fu-Rong Shang; Hong-Bin Wen, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, People’s Republic of China, Email sfrxy@sohu.com; wenhb7173@163.comObjective: The aim of this study is to investigate the relationship between admission platelet indices and 90-day clinical outcomes in patients with acute ischemic stroke (AIS) undergoing mechanical thrombectomy (MT).Methods: A retrospective analysis was conducted on 247 AIS patients with anterior circulation large vessel occlusion (LVO) treated with MT between July 2021 and April 2024. Platelet indices (PIs) were measured at admission. Participants were stratified into two groups based on 90-day modified Rankin Scale (mRS) outcomes. Multivariate regression analysis and receiver operating characteristic (ROC) curves were employed to evaluate relationships between admission platelet indices, clinical parameters, and functional outcomes.Results: Among 247 enrolled patients, those with unfavorable outcomes (mRS 3– 6) exhibited significantly higher platelet distribution width (PDW) and Mean Platelet Volume (MPV) levels compared to the favorable outcome group (mRS 0– 2). Elevated MPV remained an independent predictor of unfavorable outcomes after multivariate adjustment (OR=2.747, 95% CI: 1.791– 4.216, P< 0.001). ROC analysis identified a MPV threshold > 10.75 fL for predicting unfavorable prognosis, demonstrating 55.4% sensitivity and 81.2% specificity.Conclusion: PDW is associated with unfavorable 90-day outcomes in patients with acute anterior circulation LVO following MT, while elevated MPV may serve as a prognostic indicator for unfavorable functional outcomes in patients with acute anterior circulation LVO following MT.Keywords: mean platelet volume, mechanical thrombectomy, large vessel occlusion, stroke prognosis, platelet indices |
| format | Article |
| id | doaj-art-b7c1df5e1430460ab0ac274229fdde81 |
| institution | DOAJ |
| issn | 1178-203X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Therapeutics and Clinical Risk Management |
| spelling | doaj-art-b7c1df5e1430460ab0ac274229fdde812025-08-20T03:23:59ZengDove Medical PressTherapeutics and Clinical Risk Management1178-203X2025-05-01Volume 21Issue 1715725103074Elevated MPV: A Key Indicator of Acute Anterior Circulation Stroke Prognosis in Mechanical ThrombectomyTian SY0Yu MJMei K1Xu B2Xiao LC3Wen HB4Shang FR5Department of NeurologyDepartment of NeurologyDepartment of NeurologyDepartment of NeurologyDepartment of Neurology,Department of NeurologyShi-Yuan Tian,1 Min-Jie Yu,2 Kefu Mei,1 Bing Xu,1 Lian-Chen Xiao,1 Hong-Bin Wen,1 Fu-Rong Shang1 1Department of Neurology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, People’s Republic of China; 2School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, People’s Republic of ChinaCorrespondence: Fu-Rong Shang; Hong-Bin Wen, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, People’s Republic of China, Email sfrxy@sohu.com; wenhb7173@163.comObjective: The aim of this study is to investigate the relationship between admission platelet indices and 90-day clinical outcomes in patients with acute ischemic stroke (AIS) undergoing mechanical thrombectomy (MT).Methods: A retrospective analysis was conducted on 247 AIS patients with anterior circulation large vessel occlusion (LVO) treated with MT between July 2021 and April 2024. Platelet indices (PIs) were measured at admission. Participants were stratified into two groups based on 90-day modified Rankin Scale (mRS) outcomes. Multivariate regression analysis and receiver operating characteristic (ROC) curves were employed to evaluate relationships between admission platelet indices, clinical parameters, and functional outcomes.Results: Among 247 enrolled patients, those with unfavorable outcomes (mRS 3– 6) exhibited significantly higher platelet distribution width (PDW) and Mean Platelet Volume (MPV) levels compared to the favorable outcome group (mRS 0– 2). Elevated MPV remained an independent predictor of unfavorable outcomes after multivariate adjustment (OR=2.747, 95% CI: 1.791– 4.216, P< 0.001). ROC analysis identified a MPV threshold > 10.75 fL for predicting unfavorable prognosis, demonstrating 55.4% sensitivity and 81.2% specificity.Conclusion: PDW is associated with unfavorable 90-day outcomes in patients with acute anterior circulation LVO following MT, while elevated MPV may serve as a prognostic indicator for unfavorable functional outcomes in patients with acute anterior circulation LVO following MT.Keywords: mean platelet volume, mechanical thrombectomy, large vessel occlusion, stroke prognosis, platelet indiceshttps://www.dovepress.com/elevated-mpv-a-key-indicator-of-acute-anterior-circulation-stroke-prog-peer-reviewed-fulltext-article-TCRMMean Platelet VolumeMechanical ThrombectomyLarge Vessel OcclusionStroke PrognosisPlatelet Indices |
| spellingShingle | Tian SY Yu MJ Mei K Xu B Xiao LC Wen HB Shang FR Elevated MPV: A Key Indicator of Acute Anterior Circulation Stroke Prognosis in Mechanical Thrombectomy Therapeutics and Clinical Risk Management Mean Platelet Volume Mechanical Thrombectomy Large Vessel Occlusion Stroke Prognosis Platelet Indices |
| title | Elevated MPV: A Key Indicator of Acute Anterior Circulation Stroke Prognosis in Mechanical Thrombectomy |
| title_full | Elevated MPV: A Key Indicator of Acute Anterior Circulation Stroke Prognosis in Mechanical Thrombectomy |
| title_fullStr | Elevated MPV: A Key Indicator of Acute Anterior Circulation Stroke Prognosis in Mechanical Thrombectomy |
| title_full_unstemmed | Elevated MPV: A Key Indicator of Acute Anterior Circulation Stroke Prognosis in Mechanical Thrombectomy |
| title_short | Elevated MPV: A Key Indicator of Acute Anterior Circulation Stroke Prognosis in Mechanical Thrombectomy |
| title_sort | elevated mpv a key indicator of acute anterior circulation stroke prognosis in mechanical thrombectomy |
| topic | Mean Platelet Volume Mechanical Thrombectomy Large Vessel Occlusion Stroke Prognosis Platelet Indices |
| url | https://www.dovepress.com/elevated-mpv-a-key-indicator-of-acute-anterior-circulation-stroke-prog-peer-reviewed-fulltext-article-TCRM |
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