Polyoxometalate-based injectable coacervate inhibits HCC metastasis after incomplete radiofrequency ablation via scavenging ROS
Abstract Background Incomplete radiofrequency ablation (iRFA) stimulates residual hepatocellular carcinoma (HCC) metastasis, leading to a poor prognosis for patients. Therefore, it is imperative to develop an effective therapeutic strategy to prevent iRFA-induced HCC metastasis. Results Our study re...
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BMC
2025-01-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-024-02989-1 |
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| author | Meilin Yang Die Liu Yan Tan Jieting Chen Fan Yang Chaoming Mei Qi Zeng Yong Lin Dan Li |
| author_facet | Meilin Yang Die Liu Yan Tan Jieting Chen Fan Yang Chaoming Mei Qi Zeng Yong Lin Dan Li |
| author_sort | Meilin Yang |
| collection | DOAJ |
| description | Abstract Background Incomplete radiofrequency ablation (iRFA) stimulates residual hepatocellular carcinoma (HCC) metastasis, leading to a poor prognosis for patients. Therefore, it is imperative to develop an effective therapeutic strategy to prevent iRFA-induced HCC metastasis. Results Our study revealed that iRFA induced an abnormal increase in ROS levels within residual HCC, which enhanced tumor cell invasiveness and promoted macrophage M2 polarization, ultimately facilitating HCC metastasis. Molybdenum-based polyoxometalate (POM) is an excellent ROS-scavenging nanocluster, but its size is too small to be easily cleared by the kidneys, limiting its effectiveness in scavenging iRFA-induced ROS. To overcome this limitation, we synthesized an injectable POM-loaded coacervate delivery system named POM@Coa, which can sustainably scavenge iRFA-induced ROS by slowly releasing POM. POM@Coa markedly reduced HCC invasiveness, reversed macrophage polarization from M2 to M1, and promoted the infiltration and activation of CD8+ T cells, ultimately inhibiting HCC metastasis. Importantly, POM@Coa showed superior therapeutic efficacy to free POM in the absence of systemic toxicity. Conclusions POM@Coa exhibits the potential to decrease HCC invasiveness and activate anti-tumor immunity, opening up new avenues for the safe and effective treatment and prevention of HCC metastasis when combined with RFA. |
| format | Article |
| id | doaj-art-b7b9f3ee2672436aaa6cb44f8d0f8138 |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-b7b9f3ee2672436aaa6cb44f8d0f81382025-02-02T12:41:16ZengBMCJournal of Nanobiotechnology1477-31552025-01-0123111710.1186/s12951-024-02989-1Polyoxometalate-based injectable coacervate inhibits HCC metastasis after incomplete radiofrequency ablation via scavenging ROSMeilin Yang0Die Liu1Yan Tan2Jieting Chen3Fan Yang4Chaoming Mei5Qi Zeng6Yong Lin7Dan Li8Department of Nuclear Medicine, The Fifth Affiliated Hospital, Sun Yat-sen UniversityDepartment of Nuclear Medicine, The Fifth Affiliated Hospital, Sun Yat-sen UniversityDepartment of Nuclear Medicine, The Fifth Affiliated Hospital, Sun Yat-sen UniversityDepartment of Nuclear Medicine, The Fifth Affiliated Hospital, Sun Yat-sen UniversityDepartment of Pediatrics, The Fifth Affiliated Hospital, Sun Yat-sen UniversityDepartment of Nuclear Medicine, The Fifth Affiliated Hospital, Sun Yat-sen UniversityCancer Center, The Fifth Affiliated Hospital, Sun Yat-Sen UniversityDepartment of Psychiatry, The Fifth Affiliated Hospital, Sun Yat-sen UniversityDepartment of Nuclear Medicine, The Fifth Affiliated Hospital, Sun Yat-sen UniversityAbstract Background Incomplete radiofrequency ablation (iRFA) stimulates residual hepatocellular carcinoma (HCC) metastasis, leading to a poor prognosis for patients. Therefore, it is imperative to develop an effective therapeutic strategy to prevent iRFA-induced HCC metastasis. Results Our study revealed that iRFA induced an abnormal increase in ROS levels within residual HCC, which enhanced tumor cell invasiveness and promoted macrophage M2 polarization, ultimately facilitating HCC metastasis. Molybdenum-based polyoxometalate (POM) is an excellent ROS-scavenging nanocluster, but its size is too small to be easily cleared by the kidneys, limiting its effectiveness in scavenging iRFA-induced ROS. To overcome this limitation, we synthesized an injectable POM-loaded coacervate delivery system named POM@Coa, which can sustainably scavenge iRFA-induced ROS by slowly releasing POM. POM@Coa markedly reduced HCC invasiveness, reversed macrophage polarization from M2 to M1, and promoted the infiltration and activation of CD8+ T cells, ultimately inhibiting HCC metastasis. Importantly, POM@Coa showed superior therapeutic efficacy to free POM in the absence of systemic toxicity. Conclusions POM@Coa exhibits the potential to decrease HCC invasiveness and activate anti-tumor immunity, opening up new avenues for the safe and effective treatment and prevention of HCC metastasis when combined with RFA.https://doi.org/10.1186/s12951-024-02989-1Hepatocellular carcinoma metastasisIncomplete radiofrequency ablationReactive oxygen speciesMolybdenum-based polyoxometalate nanoclusterCoacervate |
| spellingShingle | Meilin Yang Die Liu Yan Tan Jieting Chen Fan Yang Chaoming Mei Qi Zeng Yong Lin Dan Li Polyoxometalate-based injectable coacervate inhibits HCC metastasis after incomplete radiofrequency ablation via scavenging ROS Journal of Nanobiotechnology Hepatocellular carcinoma metastasis Incomplete radiofrequency ablation Reactive oxygen species Molybdenum-based polyoxometalate nanocluster Coacervate |
| title | Polyoxometalate-based injectable coacervate inhibits HCC metastasis after incomplete radiofrequency ablation via scavenging ROS |
| title_full | Polyoxometalate-based injectable coacervate inhibits HCC metastasis after incomplete radiofrequency ablation via scavenging ROS |
| title_fullStr | Polyoxometalate-based injectable coacervate inhibits HCC metastasis after incomplete radiofrequency ablation via scavenging ROS |
| title_full_unstemmed | Polyoxometalate-based injectable coacervate inhibits HCC metastasis after incomplete radiofrequency ablation via scavenging ROS |
| title_short | Polyoxometalate-based injectable coacervate inhibits HCC metastasis after incomplete radiofrequency ablation via scavenging ROS |
| title_sort | polyoxometalate based injectable coacervate inhibits hcc metastasis after incomplete radiofrequency ablation via scavenging ros |
| topic | Hepatocellular carcinoma metastasis Incomplete radiofrequency ablation Reactive oxygen species Molybdenum-based polyoxometalate nanocluster Coacervate |
| url | https://doi.org/10.1186/s12951-024-02989-1 |
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