Discovery of Secondary Metabolites from the Sponge-Derived Fungus <i>Aspergillus templicola</i>
Combining biosynthetic gene cluster analysis with the OSMAC strategy, fractionation of the fermentation extract of <i>Aspergillus templicola</i> from the sponge <i>Agelas</i> sp. led to the isolation of four novel cytochalasins, colachalasins J–M (<b>1</b>–<b&g...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-07-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/23/7/285 |
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| Summary: | Combining biosynthetic gene cluster analysis with the OSMAC strategy, fractionation of the fermentation extract of <i>Aspergillus templicola</i> from the sponge <i>Agelas</i> sp. led to the isolation of four novel cytochalasins, colachalasins J–M (<b>1</b>–<b>4</b>), a novel cyclic pentapeptide, avellanin P (<b>5</b>), together with five known compounds (<b>6</b>–<b>10</b>). The structures of <b>1</b>–<b>9</b> were elucidated using spectroscopic data, single crystal X-ray diffraction, and Marfey’s analysis. Compound <b>2</b> exhibited potent anti-inflammatory activity in zebrafish assays. Additionally, Compounds <b>4</b> and <b>6</b> showed modest cytotoxicity against several human cancer cell lines with IC<sub>50</sub> values ranging from 2.6 to 11.2 μm. |
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| ISSN: | 1660-3397 |