Human Immunodeficiency Virus is One of the Factors Promoting Bone Tissue Inflammation in Tuberculous Spondylitis Associated with HIV Infection. Hypothesis or Reality?
The objective: analysis of clinical cases of tuberculous spondylitis in HIV-infected patients with the detection of HIV RNA in the focus of vertebral bodies destruction.Subjects and Methods. Medical records of 2 HIV-infected patients who underwent surgery for verified tuberculous spondylitis were an...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2023-04-01
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| Series: | Туберкулез и болезни лёгких |
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| Online Access: | https://www.tibl-journal.com/jour/article/view/1718 |
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| author | E. O. Peretsmanas E. A. Orlova-Morozova I. V. Esin G. D. Kaminsky T. E. Tyulkova A. E. Panova O. V. Lovacheva O. V. |
| author_facet | E. O. Peretsmanas E. A. Orlova-Morozova I. V. Esin G. D. Kaminsky T. E. Tyulkova A. E. Panova O. V. Lovacheva O. V. |
| author_sort | E. O. Peretsmanas |
| collection | DOAJ |
| description | The objective: analysis of clinical cases of tuberculous spondylitis in HIV-infected patients with the detection of HIV RNA in the focus of vertebral bodies destruction.Subjects and Methods. Medical records of 2 HIV-infected patients who underwent surgery for verified tuberculous spondylitis were analyzed. Parts of the vertebral bodies collected during surgery were examined (PCR, microbiological and histological tests), those were parts with destruction and fragments of healthy iliac bone necessary to fill the implant during corporodesis.Results. RNA HIV was detected in the foci of bone destructionas as well as M. tuberculosis DNA. The viral load in the fragments of healthy iliac bone and peripheral blood of these patients was undetectable. |
| format | Article |
| id | doaj-art-b7afb4de995f47d28db7304d8d270427 |
| institution | OA Journals |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2023-04-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-b7afb4de995f47d28db7304d8d2704272025-08-20T02:05:49ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062023-04-011012475310.58838/2075-1230-2023-101-2-47-531713Human Immunodeficiency Virus is One of the Factors Promoting Bone Tissue Inflammation in Tuberculous Spondylitis Associated with HIV Infection. Hypothesis or Reality?E. O. Peretsmanas0E. A. Orlova-Morozova1I. V. Esin2G. D. Kaminsky3T. E. Tyulkova4A. E. Panova5O. V. Lovacheva O. V.6National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health, MoscowNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health, MoscowNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health, MoscowNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health, MoscowNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health, MoscowNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health, MoscowNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health, MoscowThe objective: analysis of clinical cases of tuberculous spondylitis in HIV-infected patients with the detection of HIV RNA in the focus of vertebral bodies destruction.Subjects and Methods. Medical records of 2 HIV-infected patients who underwent surgery for verified tuberculous spondylitis were analyzed. Parts of the vertebral bodies collected during surgery were examined (PCR, microbiological and histological tests), those were parts with destruction and fragments of healthy iliac bone necessary to fill the implant during corporodesis.Results. RNA HIV was detected in the foci of bone destructionas as well as M. tuberculosis DNA. The viral load in the fragments of healthy iliac bone and peripheral blood of these patients was undetectable.https://www.tibl-journal.com/jour/article/view/1718hiv infectionviral loadtuberculous spondylitishiv rnam. tuberculosis dnavertebral destruction |
| spellingShingle | E. O. Peretsmanas E. A. Orlova-Morozova I. V. Esin G. D. Kaminsky T. E. Tyulkova A. E. Panova O. V. Lovacheva O. V. Human Immunodeficiency Virus is One of the Factors Promoting Bone Tissue Inflammation in Tuberculous Spondylitis Associated with HIV Infection. Hypothesis or Reality? Туберкулез и болезни лёгких hiv infection viral load tuberculous spondylitis hiv rna m. tuberculosis dna vertebral destruction |
| title | Human Immunodeficiency Virus is One of the Factors Promoting Bone Tissue Inflammation in Tuberculous Spondylitis Associated with HIV Infection. Hypothesis or Reality? |
| title_full | Human Immunodeficiency Virus is One of the Factors Promoting Bone Tissue Inflammation in Tuberculous Spondylitis Associated with HIV Infection. Hypothesis or Reality? |
| title_fullStr | Human Immunodeficiency Virus is One of the Factors Promoting Bone Tissue Inflammation in Tuberculous Spondylitis Associated with HIV Infection. Hypothesis or Reality? |
| title_full_unstemmed | Human Immunodeficiency Virus is One of the Factors Promoting Bone Tissue Inflammation in Tuberculous Spondylitis Associated with HIV Infection. Hypothesis or Reality? |
| title_short | Human Immunodeficiency Virus is One of the Factors Promoting Bone Tissue Inflammation in Tuberculous Spondylitis Associated with HIV Infection. Hypothesis or Reality? |
| title_sort | human immunodeficiency virus is one of the factors promoting bone tissue inflammation in tuberculous spondylitis associated with hiv infection hypothesis or reality |
| topic | hiv infection viral load tuberculous spondylitis hiv rna m. tuberculosis dna vertebral destruction |
| url | https://www.tibl-journal.com/jour/article/view/1718 |
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