Meniscal allograft transplantation survivorship and conversion to arthroplasty in patients older and younger than 40: a systematic review and meta-analysis
ABSTRACT: Background: Meniscal allograft transplantation (MAT) aims to restore meniscal deficiency with cadaveric meniscal tissue. Objectives: To compare MAT survivorship and conversion to arthroplasty in patients <40 and ≥40 years old. Data sources: Pubmed, Embase, Cochrane databases. Study eli...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Journal of Cartilage & Joint Preservation |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667254525000034 |
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| author | Andrew S. Bi Udit Dave Trevor Poulson Jared Rubin Nicole Chang Zeeshan A. Khan Nicholas J. Lemme Jorge Chahla Adam B. Yanke Brian J. Cole |
| author_facet | Andrew S. Bi Udit Dave Trevor Poulson Jared Rubin Nicole Chang Zeeshan A. Khan Nicholas J. Lemme Jorge Chahla Adam B. Yanke Brian J. Cole |
| author_sort | Andrew S. Bi |
| collection | DOAJ |
| description | ABSTRACT: Background: Meniscal allograft transplantation (MAT) aims to restore meniscal deficiency with cadaveric meniscal tissue. Objectives: To compare MAT survivorship and conversion to arthroplasty in patients <40 and ≥40 years old. Data sources: Pubmed, Embase, Cochrane databases. Study eligibility criteria: Studies were included if they evaluated medial or lateral MAT, evaluated survivorship or conversion to arthroplasty, reported mean patient age, and were published after 2004. Study appraisal and synthesis methods: Patient cohorts were sorted into 2 groups where mean age was lesser or greater than 40years. Data were pooled with the DerSimonian-Laird random-effects model. Results: A total of 1436 studies were identified, 41 included. Each study had MINORS score ≥9 indicating low risk of bias. There were 4079 patients (59.4% male) in the <40-year cohort, with mean-weighted age 31.3years, follow-up 6.4years. There were 625 patients (66.9% male) in the ≥40-year cohort, with mean-weighted age 41.2years, follow-up 8.0years. Older patients had significantly more medial MATs (300; 61.9% vs 1746; 48.4%). Patients <40 had weighted mean survivorship 76.3% (95% CI: 69.1%-83.5%) and conversion rate 5.0% (95% CI: 3.5%-6.6%). Patients ≥40 had weighted mean survivorship 72.1% (95% CI: 46.9%-97.3%) and conversion rate 13.1% (95% CI: 4.2%-22.0%). Limitations: Unavailability of individual data sets. Conclusions: There appears to be no significant differences in MAT survivorship or conversion to arthroplasty rates in patients <40 and ≥40 in appropriately indicated patients that have concomitant pathology addressed. Older patients undergoing MAT have a higher rate of medial MAT compared with younger cohorts. |
| format | Article |
| id | doaj-art-b7adde1f62c042bb95e2bc8447512796 |
| institution | OA Journals |
| issn | 2667-2545 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cartilage & Joint Preservation |
| spelling | doaj-art-b7adde1f62c042bb95e2bc84475127962025-08-20T02:01:06ZengElsevierJournal of Cartilage & Joint Preservation2667-25452025-06-015210023510.1016/j.jcjp.2025.100235Meniscal allograft transplantation survivorship and conversion to arthroplasty in patients older and younger than 40: a systematic review and meta-analysisAndrew S. Bi0Udit Dave1Trevor Poulson2Jared Rubin3Nicole Chang4Zeeshan A. Khan5Nicholas J. Lemme6Jorge Chahla7Adam B. Yanke8Brian J. Cole9Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, USADepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, USADepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, USAUniversity of Illinois College of Medicine at Chicago, Chicago, IL, USAUniversity of Illinois College of Medicine at Chicago, Chicago, IL, USADepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, USADepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, USADepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, USADepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, USADepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, USA; Brian J. Cole, Department of Orthopedic Surgery, 1611 W Harrison St, Suite 300, Chicago, IL 60612.ABSTRACT: Background: Meniscal allograft transplantation (MAT) aims to restore meniscal deficiency with cadaveric meniscal tissue. Objectives: To compare MAT survivorship and conversion to arthroplasty in patients <40 and ≥40 years old. Data sources: Pubmed, Embase, Cochrane databases. Study eligibility criteria: Studies were included if they evaluated medial or lateral MAT, evaluated survivorship or conversion to arthroplasty, reported mean patient age, and were published after 2004. Study appraisal and synthesis methods: Patient cohorts were sorted into 2 groups where mean age was lesser or greater than 40years. Data were pooled with the DerSimonian-Laird random-effects model. Results: A total of 1436 studies were identified, 41 included. Each study had MINORS score ≥9 indicating low risk of bias. There were 4079 patients (59.4% male) in the <40-year cohort, with mean-weighted age 31.3years, follow-up 6.4years. There were 625 patients (66.9% male) in the ≥40-year cohort, with mean-weighted age 41.2years, follow-up 8.0years. Older patients had significantly more medial MATs (300; 61.9% vs 1746; 48.4%). Patients <40 had weighted mean survivorship 76.3% (95% CI: 69.1%-83.5%) and conversion rate 5.0% (95% CI: 3.5%-6.6%). Patients ≥40 had weighted mean survivorship 72.1% (95% CI: 46.9%-97.3%) and conversion rate 13.1% (95% CI: 4.2%-22.0%). Limitations: Unavailability of individual data sets. Conclusions: There appears to be no significant differences in MAT survivorship or conversion to arthroplasty rates in patients <40 and ≥40 in appropriately indicated patients that have concomitant pathology addressed. Older patients undergoing MAT have a higher rate of medial MAT compared with younger cohorts.http://www.sciencedirect.com/science/article/pii/S2667254525000034AgeConversion to arthroplastyKnee preservationMeniscal allograft transplantationMeniscal transplant survivorshipMeta-analysis |
| spellingShingle | Andrew S. Bi Udit Dave Trevor Poulson Jared Rubin Nicole Chang Zeeshan A. Khan Nicholas J. Lemme Jorge Chahla Adam B. Yanke Brian J. Cole Meniscal allograft transplantation survivorship and conversion to arthroplasty in patients older and younger than 40: a systematic review and meta-analysis Journal of Cartilage & Joint Preservation Age Conversion to arthroplasty Knee preservation Meniscal allograft transplantation Meniscal transplant survivorship Meta-analysis |
| title | Meniscal allograft transplantation survivorship and conversion to arthroplasty in patients older and younger than 40: a systematic review and meta-analysis |
| title_full | Meniscal allograft transplantation survivorship and conversion to arthroplasty in patients older and younger than 40: a systematic review and meta-analysis |
| title_fullStr | Meniscal allograft transplantation survivorship and conversion to arthroplasty in patients older and younger than 40: a systematic review and meta-analysis |
| title_full_unstemmed | Meniscal allograft transplantation survivorship and conversion to arthroplasty in patients older and younger than 40: a systematic review and meta-analysis |
| title_short | Meniscal allograft transplantation survivorship and conversion to arthroplasty in patients older and younger than 40: a systematic review and meta-analysis |
| title_sort | meniscal allograft transplantation survivorship and conversion to arthroplasty in patients older and younger than 40 a systematic review and meta analysis |
| topic | Age Conversion to arthroplasty Knee preservation Meniscal allograft transplantation Meniscal transplant survivorship Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2667254525000034 |
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