Meniscal allograft transplantation survivorship and conversion to arthroplasty in patients older and younger than 40: a systematic review and meta-analysis
ABSTRACT: Background: Meniscal allograft transplantation (MAT) aims to restore meniscal deficiency with cadaveric meniscal tissue. Objectives: To compare MAT survivorship and conversion to arthroplasty in patients <40 and ≥40 years old. Data sources: Pubmed, Embase, Cochrane databases. Study eli...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
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| Series: | Journal of Cartilage & Joint Preservation |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667254525000034 |
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| Summary: | ABSTRACT: Background: Meniscal allograft transplantation (MAT) aims to restore meniscal deficiency with cadaveric meniscal tissue. Objectives: To compare MAT survivorship and conversion to arthroplasty in patients <40 and ≥40 years old. Data sources: Pubmed, Embase, Cochrane databases. Study eligibility criteria: Studies were included if they evaluated medial or lateral MAT, evaluated survivorship or conversion to arthroplasty, reported mean patient age, and were published after 2004. Study appraisal and synthesis methods: Patient cohorts were sorted into 2 groups where mean age was lesser or greater than 40years. Data were pooled with the DerSimonian-Laird random-effects model. Results: A total of 1436 studies were identified, 41 included. Each study had MINORS score ≥9 indicating low risk of bias. There were 4079 patients (59.4% male) in the <40-year cohort, with mean-weighted age 31.3years, follow-up 6.4years. There were 625 patients (66.9% male) in the ≥40-year cohort, with mean-weighted age 41.2years, follow-up 8.0years. Older patients had significantly more medial MATs (300; 61.9% vs 1746; 48.4%). Patients <40 had weighted mean survivorship 76.3% (95% CI: 69.1%-83.5%) and conversion rate 5.0% (95% CI: 3.5%-6.6%). Patients ≥40 had weighted mean survivorship 72.1% (95% CI: 46.9%-97.3%) and conversion rate 13.1% (95% CI: 4.2%-22.0%). Limitations: Unavailability of individual data sets. Conclusions: There appears to be no significant differences in MAT survivorship or conversion to arthroplasty rates in patients <40 and ≥40 in appropriately indicated patients that have concomitant pathology addressed. Older patients undergoing MAT have a higher rate of medial MAT compared with younger cohorts. |
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| ISSN: | 2667-2545 |