Zapotin mitigates breast cancer progression by targeting PKCε mediated glycolytic pathway regulation

Zapotin mitigates breast cancer progression by targeting PKCε mediated glycolytic pathway regulation

Abstract Background The breast cancer recurrence and chemoresistance has increased over the years. A novel PKC, PKCε, may promote chemoresistance by causing hypoxia and cancer metabolic rewiring. A natural flavonoid, Zapotin, in colon cancer cells may modulate PKCε expression. Therefore, this study...

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Main Authors: Khushbukhat Khan, Maryam Anwar, Yasmin Badshah, Naeem Mahmood Ashraf, Arslan Hamid, Janeen H. Trembley, Maria Shabbir, Tayyaba Afsar, Fohad Mabood Husain, Dilawar Khan, Suhail Razak
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Cancer
Subjects:
Protein kinase C epsilon
Zapotin
MD simulations
Breast cancer
Metabolic rewiring
Online Access:https://doi.org/10.1186/s12885-025-14202-z
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https://doi.org/10.1186/s12885-025-14202-z

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