TP53 and KRAS co-mutations are associated with worse outcomes in mucinous ovarian carcinomas

TP53 and KRAS co-mutations are associated with worse outcomes in mucinous ovarian carcinomas

ObjectiveMucinous ovarian carcinomas (mOC) often harbor unique molecular alterations differentiating them from other epithelial ovarian carcinoma subtypes. We sought to characterize the somatic genomic mutation patterns in mOC and elucidate their associations with oncologic outcomes.MethodsAll patie...

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Bibliographic Details
Main Authors: Yingao Zhang, Savannah Barkdull, Panayiotis D. Kontoyiannis, Alejandra Flores Legarreta, David M. Gershenson, Preetha Ramalingam, Michael M. Frumovitz, Anil K. Sood
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
Subjects:
mucinous adenocarcinoma
ovarian cancer
TP53
molecular sequencing
NGS
genomic sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1573801/full
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