Is CFTR-delF508 really absent from the apical membrane of the airway epithelium?

Is CFTR-delF508 really absent from the apical membrane of the airway epithelium?

<h4>Background</h4>Understanding where mutant CFTR is localised in airway epithelia is essential in guiding the best therapeutic approach to correct the dysfunction of the CFTR protein. The widely held paradigm is that CF patients harbouring the commonest mutation, CFTR-delF508, trap CFT...

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Main Authors: Lee A Borthwick, Phil Botha, Bernard Verdon, Malcolm J Brodlie, Aaron Gardner, David Bourn, Gail E Johnson, Mike A Gray, Andrew J Fisher
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0023226&type=printable
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