Role of Calprotectin as a Biomarker in Periodontal Disease
Periodontal disease (PD) is a common infectious and inflammatory disease characterised by inflammation of tissues surrounding and supporting the teeth and destruction of the associated alveolar bone, eventually resulting in tooth loss. This disease is caused by periodontopathic bacteria in plaque bi...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/3515026 |
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| _version_ | 1849686325781856256 |
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| author | Lili Wei Mingwen Liu Haofei Xiong |
| author_facet | Lili Wei Mingwen Liu Haofei Xiong |
| author_sort | Lili Wei |
| collection | DOAJ |
| description | Periodontal disease (PD) is a common infectious and inflammatory disease characterised by inflammation of tissues surrounding and supporting the teeth and destruction of the associated alveolar bone, eventually resulting in tooth loss. This disease is caused by periodontopathic bacteria in plaque biofilm and resultant innate and adaptive immune responses in periodontal tissues. Calprotectin (CLP) is a calcium-binding protein of the S-100 protein family and is found to be induced by activated granulocytes, monocytes, and epithelial cells. CLP has been shown to play an important role in numerous inflammatory diseases and disorders. Increasing evidence indicates that CLP is involved in the progression of PD, and its levels may be associated with disease severity and outcome of periodontal treatments. This review will summarise recent studies regarding the presence, regulation, and function of CLP in PD. The findings indicate that CLP may be an effective biomarker for diagnosis and treatment for the PD. |
| format | Article |
| id | doaj-art-b7a76ac27bea47beb9875190280a4a0a |
| institution | DOAJ |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b7a76ac27bea47beb9875190280a4a0a2025-08-20T03:22:45ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/35150263515026Role of Calprotectin as a Biomarker in Periodontal DiseaseLili Wei0Mingwen Liu1Haofei Xiong2The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, ChinaThe State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, ChinaThe State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, ChinaPeriodontal disease (PD) is a common infectious and inflammatory disease characterised by inflammation of tissues surrounding and supporting the teeth and destruction of the associated alveolar bone, eventually resulting in tooth loss. This disease is caused by periodontopathic bacteria in plaque biofilm and resultant innate and adaptive immune responses in periodontal tissues. Calprotectin (CLP) is a calcium-binding protein of the S-100 protein family and is found to be induced by activated granulocytes, monocytes, and epithelial cells. CLP has been shown to play an important role in numerous inflammatory diseases and disorders. Increasing evidence indicates that CLP is involved in the progression of PD, and its levels may be associated with disease severity and outcome of periodontal treatments. This review will summarise recent studies regarding the presence, regulation, and function of CLP in PD. The findings indicate that CLP may be an effective biomarker for diagnosis and treatment for the PD.http://dx.doi.org/10.1155/2019/3515026 |
| spellingShingle | Lili Wei Mingwen Liu Haofei Xiong Role of Calprotectin as a Biomarker in Periodontal Disease Mediators of Inflammation |
| title | Role of Calprotectin as a Biomarker in Periodontal Disease |
| title_full | Role of Calprotectin as a Biomarker in Periodontal Disease |
| title_fullStr | Role of Calprotectin as a Biomarker in Periodontal Disease |
| title_full_unstemmed | Role of Calprotectin as a Biomarker in Periodontal Disease |
| title_short | Role of Calprotectin as a Biomarker in Periodontal Disease |
| title_sort | role of calprotectin as a biomarker in periodontal disease |
| url | http://dx.doi.org/10.1155/2019/3515026 |
| work_keys_str_mv | AT liliwei roleofcalprotectinasabiomarkerinperiodontaldisease AT mingwenliu roleofcalprotectinasabiomarkerinperiodontaldisease AT haofeixiong roleofcalprotectinasabiomarkerinperiodontaldisease |