Investigating Overlapping Genetic Factors and Novel Causal Genes in Autoimmune Diseases: A Transcriptome-Wide Association and Multiomics Study
Conclusion: This study uncovers shared genetic factors across five autoimmune diseases, with FLOT1 identified as a novel causal risk gene for SLE. These findings suggest that platelet-mediated pathogenic mechanisms may contribute to SLE, providing a potential target for future therapeutic interventi...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/ijog/9595651 |
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| _version_ | 1849415872342392832 |
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| author | Leihua Fu Jieni Yu Xin Wang Zhe Chen Jiaying Sun Feidan Gao Zhijian Zhang Jiaping Fu Pan Hong Weiying Feng |
| author_facet | Leihua Fu Jieni Yu Xin Wang Zhe Chen Jiaying Sun Feidan Gao Zhijian Zhang Jiaping Fu Pan Hong Weiying Feng |
| author_sort | Leihua Fu |
| collection | DOAJ |
| description | Conclusion: This study uncovers shared genetic factors across five autoimmune diseases, with FLOT1 identified as a novel causal risk gene for SLE. These findings suggest that platelet-mediated pathogenic mechanisms may contribute to SLE, providing a potential target for future therapeutic interventions. |
| format | Article |
| id | doaj-art-b7a75e232de641deaa98322c300fbd71 |
| institution | Kabale University |
| issn | 2314-4378 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-b7a75e232de641deaa98322c300fbd712025-08-20T03:33:21ZengWileyInternational Journal of Genomics2314-43782025-01-01202510.1155/ijog/9595651Investigating Overlapping Genetic Factors and Novel Causal Genes in Autoimmune Diseases: A Transcriptome-Wide Association and Multiomics StudyLeihua Fu0Jieni Yu1Xin Wang2Zhe Chen3Jiaying Sun4Feidan Gao5Zhijian Zhang6Jiaping Fu7Pan Hong8Weiying Feng9Department of HematologyDepartment of HematologyDepartment of RheumatologyDepartment of HematologyDepartment of RheumatologyDepartment of HematologyDepartment of HematologyDepartment of HematologyDepartment of HematologyDepartment of HematologyConclusion: This study uncovers shared genetic factors across five autoimmune diseases, with FLOT1 identified as a novel causal risk gene for SLE. These findings suggest that platelet-mediated pathogenic mechanisms may contribute to SLE, providing a potential target for future therapeutic interventions.http://dx.doi.org/10.1155/ijog/9595651 |
| spellingShingle | Leihua Fu Jieni Yu Xin Wang Zhe Chen Jiaying Sun Feidan Gao Zhijian Zhang Jiaping Fu Pan Hong Weiying Feng Investigating Overlapping Genetic Factors and Novel Causal Genes in Autoimmune Diseases: A Transcriptome-Wide Association and Multiomics Study International Journal of Genomics |
| title | Investigating Overlapping Genetic Factors and Novel Causal Genes in Autoimmune Diseases: A Transcriptome-Wide Association and Multiomics Study |
| title_full | Investigating Overlapping Genetic Factors and Novel Causal Genes in Autoimmune Diseases: A Transcriptome-Wide Association and Multiomics Study |
| title_fullStr | Investigating Overlapping Genetic Factors and Novel Causal Genes in Autoimmune Diseases: A Transcriptome-Wide Association and Multiomics Study |
| title_full_unstemmed | Investigating Overlapping Genetic Factors and Novel Causal Genes in Autoimmune Diseases: A Transcriptome-Wide Association and Multiomics Study |
| title_short | Investigating Overlapping Genetic Factors and Novel Causal Genes in Autoimmune Diseases: A Transcriptome-Wide Association and Multiomics Study |
| title_sort | investigating overlapping genetic factors and novel causal genes in autoimmune diseases a transcriptome wide association and multiomics study |
| url | http://dx.doi.org/10.1155/ijog/9595651 |
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