Blending enzyme immobilization enabled high performance glucose sensor based on an n-channel organic electrochemical transistor
Organic electrochemical transistors (OECTs) have emerged as an advantageous choice for constructing biosensors due to their remarkable water compatibility, low operating voltage, and inherent amplification capability. However, the current research on bio-sensing based on OECTs predominantly employs...
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| Format: | Article |
| Language: | English |
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IOP Publishing
2024-01-01
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| Series: | Materials Research Express |
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| Online Access: | https://doi.org/10.1088/2053-1591/ad95e1 |
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| author | Cheng Shi Xingyu Jiang Qi Wang Chuan Xiang Xinyu Dong Lifeng Chi Lizhen Huang |
| author_facet | Cheng Shi Xingyu Jiang Qi Wang Chuan Xiang Xinyu Dong Lifeng Chi Lizhen Huang |
| author_sort | Cheng Shi |
| collection | DOAJ |
| description | Organic electrochemical transistors (OECTs) have emerged as an advantageous choice for constructing biosensors due to their remarkable water compatibility, low operating voltage, and inherent amplification capability. However, the current research on bio-sensing based on OECTs predominantly employs p–type material PEDOT:PSS as the channel material. Nevertheless, the utilization of a single material and its depleting characteristics impose significant limitations on device miniaturization and integration applications. We present a high-sensitivity glucose sensor based on n-channel accumulation-type OECT through immobilization the glucose oxidase on Pt gate electrode with an blending approach. The glucose oxidase directly mixed with bovine serum albumin, chitosan and immolizied on the gate electode, demonstrating a stable and sensitive response to the glucose. The modified n-channel organic electrochemical transistor demonstrates a highly sensitive response to glucose across a concentration range from μ M to mM, with a quantified stable sensitivity over 2.69 mmol ^–1 by normalizing the current change with respect to concentration. The device also exhibits selectivity towards glucose (compared with high concentrations of lactic acid, different concentration gradients of ascorbic acid, and uric acid), rendering it suitable for noninvasive glucose detection in body fluid like sweat, saliva etc This flexible and ensitive electrochemical transistor sensor holds immense potential for the development of potable healthcare biosensing. |
| format | Article |
| id | doaj-art-b7a14e8d2c3b446c9ecc55a7e17fc2bb |
| institution | OA Journals |
| issn | 2053-1591 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | Materials Research Express |
| spelling | doaj-art-b7a14e8d2c3b446c9ecc55a7e17fc2bb2025-08-20T02:07:10ZengIOP PublishingMaterials Research Express2053-15912024-01-01111111590310.1088/2053-1591/ad95e1Blending enzyme immobilization enabled high performance glucose sensor based on an n-channel organic electrochemical transistorCheng Shi0https://orcid.org/0009-0000-0973-3831Xingyu Jiang1Qi Wang2Chuan Xiang3Xinyu Dong4Lifeng Chi5Lizhen Huang6https://orcid.org/0000-0002-5211-921XInstitute of Functional Nano & Soft Materials (FUNSOM), Soochow University , 199 Ren’ai Road, Suzhou, 215123, Jiangsu, People’s Republic of ChinaInstitute of Functional Nano & Soft Materials (FUNSOM), Soochow University , 199 Ren’ai Road, Suzhou, 215123, Jiangsu, People’s Republic of ChinaInstitute of Functional Nano & Soft Materials (FUNSOM), Soochow University , 199 Ren’ai Road, Suzhou, 215123, Jiangsu, People’s Republic of ChinaInstitute of Functional Nano & Soft Materials (FUNSOM), Soochow University , 199 Ren’ai Road, Suzhou, 215123, Jiangsu, People’s Republic of ChinaInstitute of Functional Nano & Soft Materials (FUNSOM), Soochow University , 199 Ren’ai Road, Suzhou, 215123, Jiangsu, People’s Republic of ChinaInstitute of Functional Nano & Soft Materials (FUNSOM), Soochow University , 199 Ren’ai Road, Suzhou, 215123, Jiangsu, People’s Republic of China; Macao Institute of Materials Science and Engineering (MIMSE), MUST-SUDA Joint Research Center for Advanced Functional Materials, Macau University of Science and Technology , Taipa 999078, Macao, People’s Republic of ChinaInstitute of Functional Nano & Soft Materials (FUNSOM), Soochow University , 199 Ren’ai Road, Suzhou, 215123, Jiangsu, People’s Republic of ChinaOrganic electrochemical transistors (OECTs) have emerged as an advantageous choice for constructing biosensors due to their remarkable water compatibility, low operating voltage, and inherent amplification capability. However, the current research on bio-sensing based on OECTs predominantly employs p–type material PEDOT:PSS as the channel material. Nevertheless, the utilization of a single material and its depleting characteristics impose significant limitations on device miniaturization and integration applications. We present a high-sensitivity glucose sensor based on n-channel accumulation-type OECT through immobilization the glucose oxidase on Pt gate electrode with an blending approach. The glucose oxidase directly mixed with bovine serum albumin, chitosan and immolizied on the gate electode, demonstrating a stable and sensitive response to the glucose. The modified n-channel organic electrochemical transistor demonstrates a highly sensitive response to glucose across a concentration range from μ M to mM, with a quantified stable sensitivity over 2.69 mmol ^–1 by normalizing the current change with respect to concentration. The device also exhibits selectivity towards glucose (compared with high concentrations of lactic acid, different concentration gradients of ascorbic acid, and uric acid), rendering it suitable for noninvasive glucose detection in body fluid like sweat, saliva etc This flexible and ensitive electrochemical transistor sensor holds immense potential for the development of potable healthcare biosensing.https://doi.org/10.1088/2053-1591/ad95e1n–type OECTglucose sensingelectrochemistryenzyme immobilization |
| spellingShingle | Cheng Shi Xingyu Jiang Qi Wang Chuan Xiang Xinyu Dong Lifeng Chi Lizhen Huang Blending enzyme immobilization enabled high performance glucose sensor based on an n-channel organic electrochemical transistor Materials Research Express n–type OECT glucose sensing electrochemistry enzyme immobilization |
| title | Blending enzyme immobilization enabled high performance glucose sensor based on an n-channel organic electrochemical transistor |
| title_full | Blending enzyme immobilization enabled high performance glucose sensor based on an n-channel organic electrochemical transistor |
| title_fullStr | Blending enzyme immobilization enabled high performance glucose sensor based on an n-channel organic electrochemical transistor |
| title_full_unstemmed | Blending enzyme immobilization enabled high performance glucose sensor based on an n-channel organic electrochemical transistor |
| title_short | Blending enzyme immobilization enabled high performance glucose sensor based on an n-channel organic electrochemical transistor |
| title_sort | blending enzyme immobilization enabled high performance glucose sensor based on an n channel organic electrochemical transistor |
| topic | n–type OECT glucose sensing electrochemistry enzyme immobilization |
| url | https://doi.org/10.1088/2053-1591/ad95e1 |
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