Multimodal Imaging of Waldenstrom Macroglobulinemia-Associated Hyperviscosity-Related Retinopathy Treated with Plasmapheresis

While plasmapheresis is well known to significantly improve both retinal findings and systemic manifestations associated with Waldenstrom macroglobulinemia, few reports exist documenting changes in optical coherence tomography angiography (OCT-A). The authors present a case of a patient with Waldens...

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Main Authors: Michael J. Schatz, Carl S. Wilkins, Oscar Otero-Marquez, Toco Y. P. Chui, Richard B. Rosen, Meenakashi Gupta
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Case Reports in Ophthalmological Medicine
Online Access:http://dx.doi.org/10.1155/2021/6816195
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author Michael J. Schatz
Carl S. Wilkins
Oscar Otero-Marquez
Toco Y. P. Chui
Richard B. Rosen
Meenakashi Gupta
author_facet Michael J. Schatz
Carl S. Wilkins
Oscar Otero-Marquez
Toco Y. P. Chui
Richard B. Rosen
Meenakashi Gupta
author_sort Michael J. Schatz
collection DOAJ
description While plasmapheresis is well known to significantly improve both retinal findings and systemic manifestations associated with Waldenstrom macroglobulinemia, few reports exist documenting changes in optical coherence tomography angiography (OCT-A). The authors present a case of a patient with Waldenstrom macroglobulinemia who had resolution of white-centered peripheral retinal lesions and parafoveal outer nuclear layer hyperreflective material following plasmapheresis. Applying image analysis software to before and after OCT-A images, the authors were able to show an objective decrease in retinal capillary and large vessel density following plasmapheresis. This technique can be used to guide treatment and surveillance for patients with hyperviscosity-related retinopathy.
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institution Kabale University
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publishDate 2021-01-01
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series Case Reports in Ophthalmological Medicine
spelling doaj-art-b7a11c0c6ac74fd4ba5b743a034652b12025-02-03T07:24:15ZengWileyCase Reports in Ophthalmological Medicine2090-67302021-01-01202110.1155/2021/6816195Multimodal Imaging of Waldenstrom Macroglobulinemia-Associated Hyperviscosity-Related Retinopathy Treated with PlasmapheresisMichael J. Schatz0Carl S. Wilkins1Oscar Otero-Marquez2Toco Y. P. Chui3Richard B. Rosen4Meenakashi Gupta5The New York Eye and Ear InfirmaryThe New York Eye and Ear InfirmaryThe New York Eye and Ear InfirmaryThe New York Eye and Ear InfirmaryThe New York Eye and Ear InfirmaryThe New York Eye and Ear InfirmaryWhile plasmapheresis is well known to significantly improve both retinal findings and systemic manifestations associated with Waldenstrom macroglobulinemia, few reports exist documenting changes in optical coherence tomography angiography (OCT-A). The authors present a case of a patient with Waldenstrom macroglobulinemia who had resolution of white-centered peripheral retinal lesions and parafoveal outer nuclear layer hyperreflective material following plasmapheresis. Applying image analysis software to before and after OCT-A images, the authors were able to show an objective decrease in retinal capillary and large vessel density following plasmapheresis. This technique can be used to guide treatment and surveillance for patients with hyperviscosity-related retinopathy.http://dx.doi.org/10.1155/2021/6816195
spellingShingle Michael J. Schatz
Carl S. Wilkins
Oscar Otero-Marquez
Toco Y. P. Chui
Richard B. Rosen
Meenakashi Gupta
Multimodal Imaging of Waldenstrom Macroglobulinemia-Associated Hyperviscosity-Related Retinopathy Treated with Plasmapheresis
Case Reports in Ophthalmological Medicine
title Multimodal Imaging of Waldenstrom Macroglobulinemia-Associated Hyperviscosity-Related Retinopathy Treated with Plasmapheresis
title_full Multimodal Imaging of Waldenstrom Macroglobulinemia-Associated Hyperviscosity-Related Retinopathy Treated with Plasmapheresis
title_fullStr Multimodal Imaging of Waldenstrom Macroglobulinemia-Associated Hyperviscosity-Related Retinopathy Treated with Plasmapheresis
title_full_unstemmed Multimodal Imaging of Waldenstrom Macroglobulinemia-Associated Hyperviscosity-Related Retinopathy Treated with Plasmapheresis
title_short Multimodal Imaging of Waldenstrom Macroglobulinemia-Associated Hyperviscosity-Related Retinopathy Treated with Plasmapheresis
title_sort multimodal imaging of waldenstrom macroglobulinemia associated hyperviscosity related retinopathy treated with plasmapheresis
url http://dx.doi.org/10.1155/2021/6816195
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