Advanced RPL19-TRAPKI-seq method reveals mechanism of action of bioactive compounds

Advanced RPL19-TRAPKI-seq method reveals mechanism of action of bioactive compounds

Abstract Natural products play a crucial role in new drug development, but their druggability is often limited by uncertain molecular targets and insufficient research on mechanisms of action. In this study, we developed a new RPL19-TRAPKI-seq method, combining CRISPR/Cas9 and TRAP technologies, to...

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Bibliographic Details
Main Authors: Di Zhu, Junchi Hu, Renke Tan, Xiaofeng Lin, Ruina Wang, Junyan Lu, Biao Yu, Yongmei Xie, Xiaohua Ni, Chunmin Liang, Yongjun Dang, Wei Jiang
Format: Article
Language:English
Published: SpringerOpen 2025-03-01
Series:Natural Products and Bioprospecting
Subjects:
TRAP
Ribosome profiling
SBF-1
Oxidative phosphorylation
Online Access:https://doi.org/10.1007/s13659-025-00500-3
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