Antioxidant, Antibacterial, and Anticancer Activities of Bitter Gourd Fruit Extracts at Three Different Cultivation Stages
In this study, we are presenting the effect of three ripening stages of air-dried bitter gourd fruit extracts on phenolic acid composition, antioxidant, antibacterial, and anticancer activities. The results showed mature bitter gourd fruit extract in 100% methanol showing 78% DPPHº scavenging activi...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2020/7394751 |
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| author | Syed Ali Raza Naqvi Shafaqat Ali Tauqir A. Sherazi Atta-Ul Haq Muhammad Saeed Muhammad Sulman Muhammad Rizwan Saad Alkahtani Mohamed M. Abdel-Daim |
| author_facet | Syed Ali Raza Naqvi Shafaqat Ali Tauqir A. Sherazi Atta-Ul Haq Muhammad Saeed Muhammad Sulman Muhammad Rizwan Saad Alkahtani Mohamed M. Abdel-Daim |
| author_sort | Syed Ali Raza Naqvi |
| collection | DOAJ |
| description | In this study, we are presenting the effect of three ripening stages of air-dried bitter gourd fruit extracts on phenolic acid composition, antioxidant, antibacterial, and anticancer activities. The results showed mature bitter gourd fruit extract in 100% methanol showing 78% DPPHº scavenging activity. Immature dried fruit extract in 80% and 100% methanol showed promising antibacterial activities, i.e., >18.5 ± 0.21 mm zone-of-inhibition against Staphylococcus aureus, while mature dried fruit extract in 80% methanol showed 18.4 ± 0.17 mm zone-of-inhibition against Escherichia coli. Anticancer activity results of 100% methanol extracts of ripened fruit possess showed 6.72 ± 1.81 and 3.55 ± 0.51 mg/mL IC50 values with HeLa and MDBK cancer cell lines, respectively. The overall results indicate that the immature and ripen fruits of BG could be extracted in pure methanol as an antibacterial and anticancer phytomedicine. |
| format | Article |
| id | doaj-art-b79fa0a29dd848d98634c8c9722e7e08 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-b79fa0a29dd848d98634c8c9722e7e082025-08-20T03:39:29ZengWileyJournal of Chemistry2090-90632090-90712020-01-01202010.1155/2020/73947517394751Antioxidant, Antibacterial, and Anticancer Activities of Bitter Gourd Fruit Extracts at Three Different Cultivation StagesSyed Ali Raza Naqvi0Shafaqat Ali1Tauqir A. Sherazi2Atta-Ul Haq3Muhammad Saeed4Muhammad Sulman5Muhammad Rizwan6Saad Alkahtani7Mohamed M. Abdel-Daim8Department of Chemistry, Government College University, Faisalabad 38000, PakistanDepartment of Environmental Sciences, Government College University, Faisalabad 38000, PakistanDepartment of Chemistry, COMSAT University Islamabad, Abbottabad Campus, Abbottabad, PakistanDepartment of Chemistry, Government College University, Faisalabad 38000, PakistanDepartment of Chemistry, Government College University, Faisalabad 38000, PakistanDepartment of Chemistry, Government College University, Faisalabad 38000, PakistanDepartment of Environmental Sciences, Government College University, Faisalabad 38000, PakistanDepartment of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaDepartment of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaIn this study, we are presenting the effect of three ripening stages of air-dried bitter gourd fruit extracts on phenolic acid composition, antioxidant, antibacterial, and anticancer activities. The results showed mature bitter gourd fruit extract in 100% methanol showing 78% DPPHº scavenging activity. Immature dried fruit extract in 80% and 100% methanol showed promising antibacterial activities, i.e., >18.5 ± 0.21 mm zone-of-inhibition against Staphylococcus aureus, while mature dried fruit extract in 80% methanol showed 18.4 ± 0.17 mm zone-of-inhibition against Escherichia coli. Anticancer activity results of 100% methanol extracts of ripened fruit possess showed 6.72 ± 1.81 and 3.55 ± 0.51 mg/mL IC50 values with HeLa and MDBK cancer cell lines, respectively. The overall results indicate that the immature and ripen fruits of BG could be extracted in pure methanol as an antibacterial and anticancer phytomedicine.http://dx.doi.org/10.1155/2020/7394751 |
| spellingShingle | Syed Ali Raza Naqvi Shafaqat Ali Tauqir A. Sherazi Atta-Ul Haq Muhammad Saeed Muhammad Sulman Muhammad Rizwan Saad Alkahtani Mohamed M. Abdel-Daim Antioxidant, Antibacterial, and Anticancer Activities of Bitter Gourd Fruit Extracts at Three Different Cultivation Stages Journal of Chemistry |
| title | Antioxidant, Antibacterial, and Anticancer Activities of Bitter Gourd Fruit Extracts at Three Different Cultivation Stages |
| title_full | Antioxidant, Antibacterial, and Anticancer Activities of Bitter Gourd Fruit Extracts at Three Different Cultivation Stages |
| title_fullStr | Antioxidant, Antibacterial, and Anticancer Activities of Bitter Gourd Fruit Extracts at Three Different Cultivation Stages |
| title_full_unstemmed | Antioxidant, Antibacterial, and Anticancer Activities of Bitter Gourd Fruit Extracts at Three Different Cultivation Stages |
| title_short | Antioxidant, Antibacterial, and Anticancer Activities of Bitter Gourd Fruit Extracts at Three Different Cultivation Stages |
| title_sort | antioxidant antibacterial and anticancer activities of bitter gourd fruit extracts at three different cultivation stages |
| url | http://dx.doi.org/10.1155/2020/7394751 |
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