Clinical impact of pharmacogenetic risk variants in a large chinese cohort
Abstract Incorporating pharmacogenetics into clinical practice promises to improve therapeutic outcomes by optimizing drug selection and dosage based on genetic factors affecting drug response. A key advantage of PGx-guided therapy is to decrease the likelihood of adverse events. To evaluate the cli...
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2025-07-01
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| author | Chun-Yu Wei Ming-Shien Wen Chih-Kuang Cheng Yi-Jing Sheen Tsung-Chieh Yao Sing-Lian Lee Jer-Yuarn Wu Ming-Fang Tsai Ling-Hui Li Chun-houh Chen Cathy S.-J. Fann Hsin-Chou Yang Yen-Tsung Huang Hung-Hsin Chen Yi-Min Liu Erh-Chan Yeh Yu-Ching Peng Shuu-Jiun Wang Shih-Pin Chen Ming-Tsun Tsai Teh-Ia Huo Chien-Wei Su Der-Cherng Tarng Chin-Chou Huang Jong-Ling Fuh Keng-Hsin Lan Yo-Tsen Liu Ching-Liang Lu Yi-Chung Lee Yi-Hsiang Huang Chung-Pin Li Yen-Feng Wang Yu-Cheng Hsieh Yi-Ming Chen Tzu-Hung Hsiao Ching-Heng Lin Yen-Ju Chen I-Chieh Chen Chien-Lin Mao Shu-Jung Chang Yen-Lin Chang Yi-Ju Liao Chih-Hung Lai Wei-Ju Lee Hsin Tung Ting-Ting Yen Hsin-Chien Yen Jer-Hwa Chang Chun-Yao Huang Lung Chan Yung-Wei Lin Bu-Yuan Hsiao Chaur-Jong Hu Yung-Kuo Lin Yung-Feng Lin Tung-Cheng Chang Deng-Chyang Wu Jung-Yu Kan Chung-Yao Hsu Szu-Chia Chen Ching-Chia Li Chung-Feng Huang Chau-Chyun Sheu Lii-Jia Yang Chung-Hwan Chen Kuan-Mao Chen Shu-Min Chang Min-Shiuan Liou Shi-Ping Wang Kuan-Ting Lin Hui-Ping Chuang Ying-Ju Chen Joey Sin Ying-Ting Chen Chiung-Chih Chang Chang-Fu Kuo Jing-Chi Lin Ho-Chang Kuo Tien-Min Chan Chao-Wei Lee Jenn-Haung Lai Shue-Fen Luo Hao-Tsai Cheng Lian-Yu Lin Li-Chun Chang Chia-Ti Tsai Hsien-Li Kao Jian-Jyun Yu Jiann-Shing Jeng Min-Chin Chiu Tzu-Chan Hong Shun-Fa Yang Hsueh-Ju Lu Sheng-Chiang Su Pauling Chu Peng-Fei Li Chia-Lin Tsai Chia-Kuang Tsai Shih-En Tang Chien-Ming Lin Yung-Fu Wu Chih-Yang Huang Shinn-Zong Ling Chun-Chun Chang Tzu-Kai Lin Sheng-Mou Hsiao Chih-Hung Chang Chih-Dao Chen Gwo-Chin Ma Ting-Yu Chang Juey-Jen Hwang Chien-Lin Lu Kuo-Jang Kao Chen-Fang Hung Shiou-Sheng Chen Po-Yueh Chen Kochung Tsui Yuan-Tsong Chen Chien-Hsiun Chen Chih-Cheng Chien Han-Sun Chiang Yen-Ling Chiu Hsiang-Cheng Chen Pui-Yan Kwok |
| author_facet | Chun-Yu Wei Ming-Shien Wen Chih-Kuang Cheng Yi-Jing Sheen Tsung-Chieh Yao Sing-Lian Lee Jer-Yuarn Wu Ming-Fang Tsai Ling-Hui Li Chun-houh Chen Cathy S.-J. Fann Hsin-Chou Yang Yen-Tsung Huang Hung-Hsin Chen Yi-Min Liu Erh-Chan Yeh Yu-Ching Peng Shuu-Jiun Wang Shih-Pin Chen Ming-Tsun Tsai Teh-Ia Huo Chien-Wei Su Der-Cherng Tarng Chin-Chou Huang Jong-Ling Fuh Keng-Hsin Lan Yo-Tsen Liu Ching-Liang Lu Yi-Chung Lee Yi-Hsiang Huang Chung-Pin Li Yen-Feng Wang Yu-Cheng Hsieh Yi-Ming Chen Tzu-Hung Hsiao Ching-Heng Lin Yen-Ju Chen I-Chieh Chen Chien-Lin Mao Shu-Jung Chang Yen-Lin Chang Yi-Ju Liao Chih-Hung Lai Wei-Ju Lee Hsin Tung Ting-Ting Yen Hsin-Chien Yen Jer-Hwa Chang Chun-Yao Huang Lung Chan Yung-Wei Lin Bu-Yuan Hsiao Chaur-Jong Hu Yung-Kuo Lin Yung-Feng Lin Tung-Cheng Chang Deng-Chyang Wu Jung-Yu Kan Chung-Yao Hsu Szu-Chia Chen Ching-Chia Li Chung-Feng Huang Chau-Chyun Sheu Lii-Jia Yang Chung-Hwan Chen Kuan-Mao Chen Shu-Min Chang Min-Shiuan Liou Shi-Ping Wang Kuan-Ting Lin Hui-Ping Chuang Ying-Ju Chen Joey Sin Ying-Ting Chen Chiung-Chih Chang Chang-Fu Kuo Jing-Chi Lin Ho-Chang Kuo Tien-Min Chan Chao-Wei Lee Jenn-Haung Lai Shue-Fen Luo Hao-Tsai Cheng Lian-Yu Lin Li-Chun Chang Chia-Ti Tsai Hsien-Li Kao Jian-Jyun Yu Jiann-Shing Jeng Min-Chin Chiu Tzu-Chan Hong Shun-Fa Yang Hsueh-Ju Lu Sheng-Chiang Su Pauling Chu Peng-Fei Li Chia-Lin Tsai Chia-Kuang Tsai Shih-En Tang Chien-Ming Lin Yung-Fu Wu Chih-Yang Huang Shinn-Zong Ling Chun-Chun Chang Tzu-Kai Lin Sheng-Mou Hsiao Chih-Hung Chang Chih-Dao Chen Gwo-Chin Ma Ting-Yu Chang Juey-Jen Hwang Chien-Lin Lu Kuo-Jang Kao Chen-Fang Hung Shiou-Sheng Chen Po-Yueh Chen Kochung Tsui Yuan-Tsong Chen Chien-Hsiun Chen Chih-Cheng Chien Han-Sun Chiang Yen-Ling Chiu Hsiang-Cheng Chen Pui-Yan Kwok |
| author_sort | Chun-Yu Wei |
| collection | DOAJ |
| description | Abstract Incorporating pharmacogenetics into clinical practice promises to improve therapeutic outcomes by optimizing drug selection and dosage based on genetic factors affecting drug response. A key advantage of PGx-guided therapy is to decrease the likelihood of adverse events. To evaluate the clinical impact of PGx risk variants, we performed a retrospective study using genetic and clinical data from the largest Han Chinese cohort, comprising 486,956 individuals, assembled by the Taiwan Precision Medicine Initiative. We found that nearly all participants carried at least one genetic variant that could affect drug response, with many carrying multiple risk variants. Here we show the detailed analyses of four gene-drug pairs, azathioprine (NUDT15/TPMT), clopidogrel (CYP2C19), statins (ABCG2/CYP2C9/SLCO1B1), and NSAIDs (CYP2C9), for which sufficient data exists for statistical power. While the results validate previous findings that PGx risk variants are significantly associated with drug-related adverse events or ineffectiveness, the excess risk of adverse events or lack of efficacy is small compared to that found in those without the PGx risk variants, and most patients with PGx variants do not suffer from adverse events. Our results point to the complexity of implementing PGx in clinical practice and the need for integrative approaches to optimize precision medicine. |
| format | Article |
| id | doaj-art-b79f064757ae4467b43e4e2915b01752 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-b79f064757ae4467b43e4e2915b017522025-08-20T04:02:55ZengNature PortfolioNature Communications2041-17232025-07-0116111510.1038/s41467-025-61644-xClinical impact of pharmacogenetic risk variants in a large chinese cohortChun-Yu Wei0Ming-Shien Wen1Chih-Kuang Cheng2Yi-Jing Sheen3Tsung-Chieh Yao4Sing-Lian Lee5Jer-Yuarn Wu6Ming-Fang Tsai7Ling-Hui Li8Chun-houh Chen9Cathy S.-J. Fann10Hsin-Chou Yang11Yen-Tsung Huang12Hung-Hsin Chen13Yi-Min Liu14Erh-Chan Yeh15Yu-Ching Peng16Shuu-Jiun Wang17Shih-Pin Chen18Ming-Tsun Tsai19Teh-Ia Huo20Chien-Wei Su21Der-Cherng Tarng22Chin-Chou Huang23Jong-Ling Fuh24Keng-Hsin Lan25Yo-Tsen Liu26Ching-Liang Lu27Yi-Chung Lee28Yi-Hsiang Huang29Chung-Pin Li30Yen-Feng Wang31Yu-Cheng Hsieh32Yi-Ming Chen33Tzu-Hung Hsiao34Ching-Heng Lin35Yen-Ju Chen36I-Chieh Chen37Chien-Lin Mao38Shu-Jung Chang39Yen-Lin Chang40Yi-Ju Liao41Chih-Hung Lai42Wei-Ju Lee43Hsin Tung44Ting-Ting Yen45Hsin-Chien Yen46Jer-Hwa Chang47Chun-Yao Huang48Lung Chan49Yung-Wei Lin50Bu-Yuan Hsiao51Chaur-Jong Hu52Yung-Kuo Lin53Yung-Feng Lin54Tung-Cheng Chang55Deng-Chyang Wu56Jung-Yu Kan57Chung-Yao Hsu58Szu-Chia Chen59Ching-Chia Li60Chung-Feng Huang61Chau-Chyun Sheu62Lii-Jia Yang63Chung-Hwan Chen64Kuan-Mao Chen65Shu-Min Chang66Min-Shiuan Liou67Shi-Ping Wang68Kuan-Ting Lin69Hui-Ping Chuang70Ying-Ju Chen71Joey Sin72Ying-Ting Chen73Chiung-Chih Chang74Chang-Fu Kuo75Jing-Chi Lin76Ho-Chang Kuo77Tien-Min Chan78Chao-Wei Lee79Jenn-Haung Lai80Shue-Fen Luo81Hao-Tsai Cheng82Lian-Yu Lin83Li-Chun Chang84Chia-Ti Tsai85Hsien-Li Kao86Jian-Jyun Yu87Jiann-Shing Jeng88Min-Chin Chiu89Tzu-Chan Hong90Shun-Fa Yang91Hsueh-Ju Lu92Sheng-Chiang Su93Pauling Chu94Peng-Fei Li95Chia-Lin Tsai96Chia-Kuang Tsai97Shih-En Tang98Chien-Ming Lin99Yung-Fu Wu100Chih-Yang Huang101Shinn-Zong Ling102Chun-Chun Chang103Tzu-Kai Lin104Sheng-Mou Hsiao105Chih-Hung Chang106Chih-Dao Chen107Gwo-Chin Ma108Ting-Yu Chang109Juey-Jen Hwang110Chien-Lin Lu111Kuo-Jang Kao112Chen-Fang Hung113Shiou-Sheng Chen114Po-Yueh Chen115Kochung Tsui116Yuan-Tsong Chen117Chien-Hsiun Chen118Chih-Cheng Chien119Han-Sun Chiang120Yen-Ling Chiu121Hsiang-Cheng Chen122Pui-Yan Kwok123Institute of Biomedical Sciences, Academia SinicaDivision of Cardiology, Chang Gung Memorial Hospital, Linkou BranchDepartment of Neurology, Chang Gung Memorial Hospital, Linkou BranchDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General HospitalDivision of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial HospitalDepartment of Internal Medicine, Koo Foundation Sun Yat-Sen Cancer CenterInstitute of Biomedical Sciences, Academia SinicaInstitute of Biomedical Sciences, Academia SinicaInstitute of Biomedical Sciences, Academia SinicaInstitute of Statistical Science, Academia SinicaInstitute of Biomedical Sciences, Academia SinicaInstitute of Statistical Science, Academia SinicaInstitute of Statistical Science, Academia SinicaInstitute of Biomedical Sciences, Academia SinicaInstitute of Biomedical Sciences, Academia SinicaInstitute of Biomedical Sciences, Academia SinicaDepartment of Pathology and Laboratory Medicine, Taipei Veterans General HospitalDepartment of Neurology, Neurological Institute, Taipei Veterans General HospitalDepartment of Neurology, Neurological Institute, Taipei Veterans General HospitalInstitute of Clinical Medicine, National Yang Ming Chiao Tung UniversityDivision of Basic Research, Department of Medical Research, Taipei Veterans General HospitalInstitute of Clinical Medicine, National Yang Ming Chiao Tung UniversityDivision of Nephrology, Department of Medicine, Taipei Veterans General HospitalFaculty of Medicine, School of Medicine, National Yang Ming Chiao Tung UniversityDepartment of Neurology, Neurological Institute, Taipei Veterans General HospitalInstitute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung UniversitySchool of Medicine, National Yang Ming Chiao Tung UniversityFaculty of Medicine, School of Medicine, National Yang Ming Chiao Tung UniversityDepartment of Neurology, Neurological Institute, Taipei Veterans General HospitalDivision of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General HospitalDivision of Clinical Skills Training, Department of Medical Education, Taipei Veterans General HospitalDepartment of Neurology, Neurological Institute, Taipei Veterans General HospitalDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing UniversityDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing UniversityDepartment of Medical Research, Taichung Veterans General HospitalDepartment of Medical Research, Taichung Veterans General HospitalDepartment of Medical Research, Taichung Veterans General HospitalDepartment of Medical Research, Taichung Veterans General HospitalDepartment of Medical Research, Taichung Veterans General HospitalDepartment of Medical Research, Taichung Veterans General HospitalDepartment of Pharmacy, Taichung Veterans General HospitalDepartment of Pharmacy, Taichung Veterans General HospitalDepartment of Medicine and Cardiovascular Center, Taichung Veterans General HospitalDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing UniversityDepartment of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing UniversityDepartment of Otolaryngology, Taichung Veterans General HospitalDivision of Pediatric Genetics and Metabolism, Children’s Medical Center, Taichung Veterans General HospitalSchool of Respiratory Therapy, College of Medicine, Taipei Medical UniversityDivision of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical UniversityDepartment of Neurology, Shuang Ho Hospital, Taipei Medical UniversityDepartment of Urology, School of Medicine, College of Medicine and TMU Research Center of Urology and Kidney (TMU-RCUK), Taipei Medical UniversityDivision of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical UniversityDepartment of Neurology, Shuang Ho Hospital, Taipei Medical UniversityDivision of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical UniversityDepartment of Medicine Research, Taipei Medical University HospitalDivision of Colorectal Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical UniversityDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical UniversityDivision of Breast Oncology and Surgery, Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung Medical UniversitySleep Medicine Center, Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical UniversityDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical UniversityDepartment of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical UniversityHepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical UniversityDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical UniversityDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical UniversityOrthopaedic Research Center and Department of Orthopedics, College of Medicine, Kaohsiung Medical UniversityInstitute of Biomedical Sciences, Academia SinicaInstitute of Biomedical Sciences, Academia SinicaInstitute of Biomedical Sciences, Academia SinicaInstitute of Biomedical Sciences, Academia SinicaInstitute of Biomedical Sciences, Academia SinicaInstitute of Biomedical Sciences, Academia SinicaInstitute of Biomedical Sciences, Academia SinicaInstitute of Biomedical Sciences, Academia SinicaInstitute of Biomedical Sciences, Academia SinicaDepartment of Neurology, Cognition and Aging Center, Kaohsiung Chang Gung Memorial HospitalCenter for Artificial Intelligence in Medicine, Chang Gung Memorial HospitalDivision of Allergy Immunology and Rheumatology, Chang Gung Memorial HospitalPediatric Internal Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial HospitalDivision of Rheumatology, Allergy and Immunology, Chang Gung Memorial HospitalDivision of General Surgery, Department of Surgery, Linkou Chang Gung Memorial HospitalDivision of Rheumatology, Allergy and Immunology, Chang Gung Memorial HospitalDepartment of Rheumatology, Allergy and Immunology, Linkou Chang Gung Memorial HospitalDepartment of Gastroenterology and Hepatology, New Taipei Municipal TuCheng HospitalDepartment of Internal Medicine, National Taiwan University HospitalDepartment of Internal Medicine, National Taiwan University HospitalDepartment of Internal Medicine, National Taiwan University HospitalDepartment of Internal Medicine, National Taiwan University HospitalDepartment of Internal Medicine, National Taiwan University Hospital, Yunlin BranchDepartment of Neurology, National Taiwan University HospitalDepartment of Internal Medicine, National Taiwan University Hospital, Yunlin BranchDepartment of Internal Medicine, National Taiwan University College of MedicineInstitute of Medicine, Chung Shan Medical UniversityDivision of Hematology and Oncology, Department of Internal Medicine, Chung Shan Medical University HospitalEndocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical CenterNephrology, Tri-Service General Hospital, National Defense Medical CenterEndocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical CenterNeurology, Tri-Service General Hospital, National Defense Medical CenterNeurology, Tri-Service General Hospital, National Defense Medical CenterPulmonary Medicine, Tri-Service General Hospital, National Defense Medical CenterPediatrics, Tri-Service General Hospital, National Defense Medical CenterDepartment of Medical Research, Tri-Service General Hospital, National Defense Medical CenterCardiovascular and Mitochondria Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical FoundationBioinnovation Center, Buddhist Tzu Chi Medical FoundationDepartment of Laboratory Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical FoundationDepartment of Dermatology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical FoundationDepartment of Obstetrics and Gynecology, Far Eastern Memorial HospitalGraduate School of Biotechnology and Bioengineering, Yuan Ze UniversityDepartment of Family Medicine, Far Eastern Memorial HospitalDepartment of Genomic Medicine and Center for Medical Genetics, Changhua Christian HospitalDepartment of Genomic Medicine and Center for Medical Genetics, Changhua Christian HospitalDepartment of Cardiology, Fu Jen Catholic University Hospital, Fu Jen Catholic UniversitySchool of Medicine, College of Medicine, Fu Jen Catholic UniversityKoo Foundation Sun Yat-Sen Cancer CenterKoo Foundation Sun Yat-Sen Cancer CenterDivision of Urology, Taipei City Hospital Ren Ai BranchDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian HospitalSchool of Medicine, Fu-Jen Catholic UniversityInstitute of Biomedical Sciences, Academia SinicaInstitute of Biomedical Sciences, Academia SinicaSchool of Medicine, Fu-Jen Catholic UniversitySchool of Medicine, College of Medicine, Fu Jen Catholic UniversityDepartment of Medical Research, Far Eastern Memorial HospitalDivision of Rheumatology, Immunology and Allergy, Tri-Service General HospitalInstitute of Biomedical Sciences, Academia SinicaAbstract Incorporating pharmacogenetics into clinical practice promises to improve therapeutic outcomes by optimizing drug selection and dosage based on genetic factors affecting drug response. A key advantage of PGx-guided therapy is to decrease the likelihood of adverse events. To evaluate the clinical impact of PGx risk variants, we performed a retrospective study using genetic and clinical data from the largest Han Chinese cohort, comprising 486,956 individuals, assembled by the Taiwan Precision Medicine Initiative. We found that nearly all participants carried at least one genetic variant that could affect drug response, with many carrying multiple risk variants. Here we show the detailed analyses of four gene-drug pairs, azathioprine (NUDT15/TPMT), clopidogrel (CYP2C19), statins (ABCG2/CYP2C9/SLCO1B1), and NSAIDs (CYP2C9), for which sufficient data exists for statistical power. While the results validate previous findings that PGx risk variants are significantly associated with drug-related adverse events or ineffectiveness, the excess risk of adverse events or lack of efficacy is small compared to that found in those without the PGx risk variants, and most patients with PGx variants do not suffer from adverse events. Our results point to the complexity of implementing PGx in clinical practice and the need for integrative approaches to optimize precision medicine.https://doi.org/10.1038/s41467-025-61644-x |
| spellingShingle | Chun-Yu Wei Ming-Shien Wen Chih-Kuang Cheng Yi-Jing Sheen Tsung-Chieh Yao Sing-Lian Lee Jer-Yuarn Wu Ming-Fang Tsai Ling-Hui Li Chun-houh Chen Cathy S.-J. Fann Hsin-Chou Yang Yen-Tsung Huang Hung-Hsin Chen Yi-Min Liu Erh-Chan Yeh Yu-Ching Peng Shuu-Jiun Wang Shih-Pin Chen Ming-Tsun Tsai Teh-Ia Huo Chien-Wei Su Der-Cherng Tarng Chin-Chou Huang Jong-Ling Fuh Keng-Hsin Lan Yo-Tsen Liu Ching-Liang Lu Yi-Chung Lee Yi-Hsiang Huang Chung-Pin Li Yen-Feng Wang Yu-Cheng Hsieh Yi-Ming Chen Tzu-Hung Hsiao Ching-Heng Lin Yen-Ju Chen I-Chieh Chen Chien-Lin Mao Shu-Jung Chang Yen-Lin Chang Yi-Ju Liao Chih-Hung Lai Wei-Ju Lee Hsin Tung Ting-Ting Yen Hsin-Chien Yen Jer-Hwa Chang Chun-Yao Huang Lung Chan Yung-Wei Lin Bu-Yuan Hsiao Chaur-Jong Hu Yung-Kuo Lin Yung-Feng Lin Tung-Cheng Chang Deng-Chyang Wu Jung-Yu Kan Chung-Yao Hsu Szu-Chia Chen Ching-Chia Li Chung-Feng Huang Chau-Chyun Sheu Lii-Jia Yang Chung-Hwan Chen Kuan-Mao Chen Shu-Min Chang Min-Shiuan Liou Shi-Ping Wang Kuan-Ting Lin Hui-Ping Chuang Ying-Ju Chen Joey Sin Ying-Ting Chen Chiung-Chih Chang Chang-Fu Kuo Jing-Chi Lin Ho-Chang Kuo Tien-Min Chan Chao-Wei Lee Jenn-Haung Lai Shue-Fen Luo Hao-Tsai Cheng Lian-Yu Lin Li-Chun Chang Chia-Ti Tsai Hsien-Li Kao Jian-Jyun Yu Jiann-Shing Jeng Min-Chin Chiu Tzu-Chan Hong Shun-Fa Yang Hsueh-Ju Lu Sheng-Chiang Su Pauling Chu Peng-Fei Li Chia-Lin Tsai Chia-Kuang Tsai Shih-En Tang Chien-Ming Lin Yung-Fu Wu Chih-Yang Huang Shinn-Zong Ling Chun-Chun Chang Tzu-Kai Lin Sheng-Mou Hsiao Chih-Hung Chang Chih-Dao Chen Gwo-Chin Ma Ting-Yu Chang Juey-Jen Hwang Chien-Lin Lu Kuo-Jang Kao Chen-Fang Hung Shiou-Sheng Chen Po-Yueh Chen Kochung Tsui Yuan-Tsong Chen Chien-Hsiun Chen Chih-Cheng Chien Han-Sun Chiang Yen-Ling Chiu Hsiang-Cheng Chen Pui-Yan Kwok Clinical impact of pharmacogenetic risk variants in a large chinese cohort Nature Communications |
| title | Clinical impact of pharmacogenetic risk variants in a large chinese cohort |
| title_full | Clinical impact of pharmacogenetic risk variants in a large chinese cohort |
| title_fullStr | Clinical impact of pharmacogenetic risk variants in a large chinese cohort |
| title_full_unstemmed | Clinical impact of pharmacogenetic risk variants in a large chinese cohort |
| title_short | Clinical impact of pharmacogenetic risk variants in a large chinese cohort |
| title_sort | clinical impact of pharmacogenetic risk variants in a large chinese cohort |
| url | https://doi.org/10.1038/s41467-025-61644-x |
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