The multimodality neuroimage findings in individuals with Tourette syndrome
Chronic tic disorder and Gilles de la Tourette syndrome are very common childhood-onset diseases. However, the pathophysiology underlying these disorders is not yet clear and most studies focus on the disinhibition of the cortico-striatal-thalamo-cortical circuit. Although dysfunction of this circui...
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Elsevier
2020-10-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957220300462 |
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| author | Chia-Jui Hsu Lee Chin Wong Hsin-Pei Wang Wang-Tso Lee |
| author_facet | Chia-Jui Hsu Lee Chin Wong Hsin-Pei Wang Wang-Tso Lee |
| author_sort | Chia-Jui Hsu |
| collection | DOAJ |
| description | Chronic tic disorder and Gilles de la Tourette syndrome are very common childhood-onset diseases. However, the pathophysiology underlying these disorders is not yet clear and most studies focus on the disinhibition of the cortico-striatal-thalamo-cortical circuit. Although dysfunction of this circuit is possible, routine clinical neuroimaging studies such as T1-weighted or T2-weighted MRI usually reveal normal results. Therefore, special neuroimaging techniques may be needed to investigate the possible microstructural or functional changes in the brain. Previous structural studies, such as those using diffusion tensor imaging, and volumetric MRI studies, revealed the main abnormalities to be located in the cortico-striatal-thalamo-cortical circuit and to be related to brain regions such as basal ganglion, thalamus, frontal cortex, and motor cortex. Some other potential regions, such as the amygdala, hippocampus or cerebellum, are also occasionally reported. Perfusion studies, such as those using positron emission tomography or functional MRI, also suggest hemodynamic changes over those brain regions related to the cortico-striatal-thalamo-cortical circuit. However, the results can be different in adult and pediatric groups, and neuroimaging findings are also inconsistent between different studies, which may reflect the high diversity of this disease or differences in enrolled patient groups with different comorbidities. Therefore, in this review article, we will focus on the neuroimaging findings relating to Tourette syndrome in different age groups using different imaging techniques. |
| format | Article |
| id | doaj-art-b798fab16c7c43b7bf134faedf2df001 |
| institution | DOAJ |
| issn | 1875-9572 |
| language | English |
| publishDate | 2020-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-b798fab16c7c43b7bf134faedf2df0012025-08-20T03:22:45ZengElsevierPediatrics and Neonatology1875-95722020-10-0161546747410.1016/j.pedneo.2020.03.007The multimodality neuroimage findings in individuals with Tourette syndromeChia-Jui Hsu0Lee Chin Wong1Hsin-Pei Wang2Wang-Tso Lee3Department of Pediatrics, Taipei City Hospital, Yangming Branch, Taipei, Taiwan; Department of Pediatrics, National Taiwan University Hospital Hsinchu Branch, Hsinchu, Taiwan; Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Pediatrics, Cathay General Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, TaiwanGraduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Pediatrics, National Taiwan University Hospital Yunlin Branch, Yunlin, TaiwanGraduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Pediatric Neurology, National Taiwan University Children's Hospital, Taipei, Taiwan; Department of Pediatrics, National Taiwan University College of Medicine, Taipei, Taiwan; Corresponding author. Department of Pediatric Neurology, National Taiwan University Children's Hospital, 8, Chung-Shan South Road, Taipei, 100, Taiwan.Chronic tic disorder and Gilles de la Tourette syndrome are very common childhood-onset diseases. However, the pathophysiology underlying these disorders is not yet clear and most studies focus on the disinhibition of the cortico-striatal-thalamo-cortical circuit. Although dysfunction of this circuit is possible, routine clinical neuroimaging studies such as T1-weighted or T2-weighted MRI usually reveal normal results. Therefore, special neuroimaging techniques may be needed to investigate the possible microstructural or functional changes in the brain. Previous structural studies, such as those using diffusion tensor imaging, and volumetric MRI studies, revealed the main abnormalities to be located in the cortico-striatal-thalamo-cortical circuit and to be related to brain regions such as basal ganglion, thalamus, frontal cortex, and motor cortex. Some other potential regions, such as the amygdala, hippocampus or cerebellum, are also occasionally reported. Perfusion studies, such as those using positron emission tomography or functional MRI, also suggest hemodynamic changes over those brain regions related to the cortico-striatal-thalamo-cortical circuit. However, the results can be different in adult and pediatric groups, and neuroimaging findings are also inconsistent between different studies, which may reflect the high diversity of this disease or differences in enrolled patient groups with different comorbidities. Therefore, in this review article, we will focus on the neuroimaging findings relating to Tourette syndrome in different age groups using different imaging techniques.http://www.sciencedirect.com/science/article/pii/S1875957220300462Gilles de la Tourette syndromecortico-striatal-thalamo-cortical circuitdiffusion tensor imagediffusion spectrum imagechildren |
| spellingShingle | Chia-Jui Hsu Lee Chin Wong Hsin-Pei Wang Wang-Tso Lee The multimodality neuroimage findings in individuals with Tourette syndrome Pediatrics and Neonatology Gilles de la Tourette syndrome cortico-striatal-thalamo-cortical circuit diffusion tensor image diffusion spectrum image children |
| title | The multimodality neuroimage findings in individuals with Tourette syndrome |
| title_full | The multimodality neuroimage findings in individuals with Tourette syndrome |
| title_fullStr | The multimodality neuroimage findings in individuals with Tourette syndrome |
| title_full_unstemmed | The multimodality neuroimage findings in individuals with Tourette syndrome |
| title_short | The multimodality neuroimage findings in individuals with Tourette syndrome |
| title_sort | multimodality neuroimage findings in individuals with tourette syndrome |
| topic | Gilles de la Tourette syndrome cortico-striatal-thalamo-cortical circuit diffusion tensor image diffusion spectrum image children |
| url | http://www.sciencedirect.com/science/article/pii/S1875957220300462 |
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