Optimization of Drug Delivery Systems for Intraperitoneal Therapy to Extend the Residence Time of the Chemotherapeutic Agent
Intraperitoneal (IP) chemotherapy is an effective way of treating peritoneal carcinomatosis of colorectal origin after complete cytoreduction. Although IP therapy has been already performed for many years, no standardized treatment design has been developed in terms of schedule, residence time, drug...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/720858 |
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| _version_ | 1850176256802291712 |
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| author | L. De Smet W. Ceelen J. P. Remon C. Vervaet |
| author_facet | L. De Smet W. Ceelen J. P. Remon C. Vervaet |
| author_sort | L. De Smet |
| collection | DOAJ |
| description | Intraperitoneal (IP) chemotherapy is an effective way of treating peritoneal carcinomatosis of colorectal origin after complete cytoreduction. Although IP therapy has been already performed for many years, no standardized treatment design has been developed in terms of schedule, residence time, drug, or carrier solution. Because of the fast clearance of the conventional intravenous (IV) drug delivery systems used for IP therapy, a lot of research is performed to optimize IP drug delivery and extend the residence time of the cytotoxic agent in the peritoneal cavity. This paper reviews the recent advances made in drug delivery systems for IP chemotherapy, discussing the use of microparticles, nanoparticles, liposomes, micelles, implants, and injectable depots for IP delivery. |
| format | Article |
| id | doaj-art-b798455b6b1a46a1b081476c19c7ecd7 |
| institution | OA Journals |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-b798455b6b1a46a1b081476c19c7ecd72025-08-20T02:19:18ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/720858720858Optimization of Drug Delivery Systems for Intraperitoneal Therapy to Extend the Residence Time of the Chemotherapeutic AgentL. De Smet0W. Ceelen1J. P. Remon2C. Vervaet3Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, 9000 Ghent, BelgiumLaboratory of Experimental Surgery, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, BelgiumLaboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, 9000 Ghent, BelgiumLaboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, 9000 Ghent, BelgiumIntraperitoneal (IP) chemotherapy is an effective way of treating peritoneal carcinomatosis of colorectal origin after complete cytoreduction. Although IP therapy has been already performed for many years, no standardized treatment design has been developed in terms of schedule, residence time, drug, or carrier solution. Because of the fast clearance of the conventional intravenous (IV) drug delivery systems used for IP therapy, a lot of research is performed to optimize IP drug delivery and extend the residence time of the cytotoxic agent in the peritoneal cavity. This paper reviews the recent advances made in drug delivery systems for IP chemotherapy, discussing the use of microparticles, nanoparticles, liposomes, micelles, implants, and injectable depots for IP delivery.http://dx.doi.org/10.1155/2013/720858 |
| spellingShingle | L. De Smet W. Ceelen J. P. Remon C. Vervaet Optimization of Drug Delivery Systems for Intraperitoneal Therapy to Extend the Residence Time of the Chemotherapeutic Agent The Scientific World Journal |
| title | Optimization of Drug Delivery Systems for Intraperitoneal Therapy to Extend the Residence Time of the Chemotherapeutic Agent |
| title_full | Optimization of Drug Delivery Systems for Intraperitoneal Therapy to Extend the Residence Time of the Chemotherapeutic Agent |
| title_fullStr | Optimization of Drug Delivery Systems for Intraperitoneal Therapy to Extend the Residence Time of the Chemotherapeutic Agent |
| title_full_unstemmed | Optimization of Drug Delivery Systems for Intraperitoneal Therapy to Extend the Residence Time of the Chemotherapeutic Agent |
| title_short | Optimization of Drug Delivery Systems for Intraperitoneal Therapy to Extend the Residence Time of the Chemotherapeutic Agent |
| title_sort | optimization of drug delivery systems for intraperitoneal therapy to extend the residence time of the chemotherapeutic agent |
| url | http://dx.doi.org/10.1155/2013/720858 |
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