MicroRNA and Microvascular Complications of Diabetes
In the last decade, miRNAs have received substantial attention as potential players of diabetes microvascular complications, affecting the kidney, the retina, and the peripheral neurons. Compelling evidence indicates that abnormally expressed miRNAs have pivotal roles in key pathogenic processes of...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/6890501 |
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| _version_ | 1850176253932339200 |
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| author | F. Barutta S. Bellini R. Mastrocola G. Bruno G. Gruden |
| author_facet | F. Barutta S. Bellini R. Mastrocola G. Bruno G. Gruden |
| author_sort | F. Barutta |
| collection | DOAJ |
| description | In the last decade, miRNAs have received substantial attention as potential players of diabetes microvascular complications, affecting the kidney, the retina, and the peripheral neurons. Compelling evidence indicates that abnormally expressed miRNAs have pivotal roles in key pathogenic processes of microvascular complications, such as fibrosis, apoptosis, inflammation, and angiogenesis. Moreover, clinical research into innovative both diagnostic and prognostic tools suggests circulating miRNAs as possible novel noninvasive markers of diabetes microvascular complications. In this review, we summarize current knowledge and understanding of the role of miRNAs in the injury to the microvascular bed in diabetes and discuss the potential of miRNAs as clinical biomarkers of diabetes microvascular complications. |
| format | Article |
| id | doaj-art-b7908e685ca24177b3955db5a4cf9158 |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-b7908e685ca24177b3955db5a4cf91582025-08-20T02:19:18ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/68905016890501MicroRNA and Microvascular Complications of DiabetesF. Barutta0S. Bellini1R. Mastrocola2G. Bruno3G. Gruden4Laboratory of Diabetic Nephropathy, Department of Medical Sciences, University of Turin, Turin, ItalyLaboratory of Diabetic Nephropathy, Department of Medical Sciences, University of Turin, Turin, ItalyDepartment of Clinical and Biological Sciences, University of Turin, Turin, ItalyLaboratory of Diabetic Nephropathy, Department of Medical Sciences, University of Turin, Turin, ItalyLaboratory of Diabetic Nephropathy, Department of Medical Sciences, University of Turin, Turin, ItalyIn the last decade, miRNAs have received substantial attention as potential players of diabetes microvascular complications, affecting the kidney, the retina, and the peripheral neurons. Compelling evidence indicates that abnormally expressed miRNAs have pivotal roles in key pathogenic processes of microvascular complications, such as fibrosis, apoptosis, inflammation, and angiogenesis. Moreover, clinical research into innovative both diagnostic and prognostic tools suggests circulating miRNAs as possible novel noninvasive markers of diabetes microvascular complications. In this review, we summarize current knowledge and understanding of the role of miRNAs in the injury to the microvascular bed in diabetes and discuss the potential of miRNAs as clinical biomarkers of diabetes microvascular complications.http://dx.doi.org/10.1155/2018/6890501 |
| spellingShingle | F. Barutta S. Bellini R. Mastrocola G. Bruno G. Gruden MicroRNA and Microvascular Complications of Diabetes International Journal of Endocrinology |
| title | MicroRNA and Microvascular Complications of Diabetes |
| title_full | MicroRNA and Microvascular Complications of Diabetes |
| title_fullStr | MicroRNA and Microvascular Complications of Diabetes |
| title_full_unstemmed | MicroRNA and Microvascular Complications of Diabetes |
| title_short | MicroRNA and Microvascular Complications of Diabetes |
| title_sort | microrna and microvascular complications of diabetes |
| url | http://dx.doi.org/10.1155/2018/6890501 |
| work_keys_str_mv | AT fbarutta micrornaandmicrovascularcomplicationsofdiabetes AT sbellini micrornaandmicrovascularcomplicationsofdiabetes AT rmastrocola micrornaandmicrovascularcomplicationsofdiabetes AT gbruno micrornaandmicrovascularcomplicationsofdiabetes AT ggruden micrornaandmicrovascularcomplicationsofdiabetes |