Protective effect of Korean red ginseng water extract on levothyroxine-induced hyperthyroidism and propylthiouracil-induced hypothyroidism in rats
Background: Korean red ginseng extract (KRGE) (Family: Araliaceae) is one of the most widely used traditional herbs in Asia. Multiple studies have shown that KRGE has anti-inflammation, anti-fatigue, anti-obesity, anti-oxidant, and anti-cancer effects. Methods: Sprague-Dawley rats were divided into...
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Elsevier
2024-09-01
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| Series: | Integrative Medicine Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213422024000519 |
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| author | Lei Huang Won Young Jang Ji Hye Yoon Zhenyan Piao Jinghan Su Dong Seon Kim Ki Woong Kwon Ji Won Kim Sang Hee Park Sunggyu Kim Jong-Hoon Kim Jae Youl Cho |
| author_facet | Lei Huang Won Young Jang Ji Hye Yoon Zhenyan Piao Jinghan Su Dong Seon Kim Ki Woong Kwon Ji Won Kim Sang Hee Park Sunggyu Kim Jong-Hoon Kim Jae Youl Cho |
| author_sort | Lei Huang |
| collection | DOAJ |
| description | Background: Korean red ginseng extract (KRGE) (Family: Araliaceae) is one of the most widely used traditional herbs in Asia. Multiple studies have shown that KRGE has anti-inflammation, anti-fatigue, anti-obesity, anti-oxidant, and anti-cancer effects. Methods: Sprague-Dawley rats were divided into five groups for PTU-induced hypothyroidism and six groups for LT4-induced hyperthyroidism. At the experiment's conclusion, rats were sacrificed, and blood, thyroid gland, and liver samples were collected. Body weight was recorded weekly, and serum hormone levels were assessed using enzyme-linked immunoassay. Thyroid gland and liver tissues were stained with hematoxylin and eosin. KRGE was prepared in 0.5% CMC and stored at 4 °C before administration. Results: In the LT4-induced hyperthyroidism model, KRGE prevented decreases in body weight, thyroid gland weight, liver weight, serum glucose, and thyroid hormone levels compared to the PTU group. It also reduced increases in T3, T4, and serum aspartate aminotransferase levels after LT4 treatment. Additionally, KRGE improved thyroid gland and liver histopathology, effects not observed in the PTU-induced hypothyroidism model. Conclusion: All things considered, our research points to KRGE's potential protective role in rat hyperthyroidism caused by LT4 by lowering thyroid hormone production. |
| format | Article |
| id | doaj-art-b788e37f2f054fd383abec9684aeb0a6 |
| institution | Kabale University |
| issn | 2213-4220 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Integrative Medicine Research |
| spelling | doaj-art-b788e37f2f054fd383abec9684aeb0a62025-08-20T03:24:44ZengElsevierIntegrative Medicine Research2213-42202024-09-0113310107110.1016/j.imr.2024.101071Protective effect of Korean red ginseng water extract on levothyroxine-induced hyperthyroidism and propylthiouracil-induced hypothyroidism in ratsLei Huang0Won Young Jang1Ji Hye Yoon2Zhenyan Piao3Jinghan Su4Dong Seon Kim5Ki Woong Kwon6Ji Won Kim7Sang Hee Park8Sunggyu Kim9Jong-Hoon Kim10Jae Youl Cho11Department of Biocosmetics, Sungkyunkwan University, Suwon, Republic of KoreaDepartment of Integrative Biotechnology, Biomedical Institute for Convergence of SKKU (BICS), Sungkyunkwan University, Suwon, Republic of KoreaDepartment of Biocosmetics, Sungkyunkwan University, Suwon, Republic of KoreaDepartment of Integrative Biotechnology, Biomedical Institute for Convergence of SKKU (BICS), Sungkyunkwan University, Suwon, Republic of KoreaDepartment of Integrative Biotechnology, Biomedical Institute for Convergence of SKKU (BICS), Sungkyunkwan University, Suwon, Republic of KoreaDepartment of Integrative Biotechnology, Biomedical Institute for Convergence of SKKU (BICS), Sungkyunkwan University, Suwon, Republic of KoreaDepartment of Integrative Biotechnology, Biomedical Institute for Convergence of SKKU (BICS), Sungkyunkwan University, Suwon, Republic of KoreaDepartment of Integrative Biotechnology, Biomedical Institute for Convergence of SKKU (BICS), Sungkyunkwan University, Suwon, Republic of KoreaDepartment of Biocosmetics, Sungkyunkwan University, Suwon, Republic of KoreaDepartment of Biocosmetics, Sungkyunkwan University, Suwon, Republic of Korea; Department of Integrative Biotechnology, Biomedical Institute for Convergence of SKKU (BICS), Sungkyunkwan University, Suwon, Republic of KoreaDepartment of Veterinary Physiology College of Medicine, Chonbuk National University Iksan, Republic of Korea; Corresponding authors at: Department of Veterinary Physiology College of Medicine, Chonbuk National University Iksan, Republic of Korea (J. H. Kim); Department of Integrative Biotechnology, Biomedical Institute for Convergence of SKKU (BICS), Sungkyunkwan University, Suwon 16419, Republic of Korea (J.Y. Cho).Department of Biocosmetics, Sungkyunkwan University, Suwon, Republic of Korea; Department of Integrative Biotechnology, Biomedical Institute for Convergence of SKKU (BICS), Sungkyunkwan University, Suwon, Republic of Korea; Corresponding authors at: Department of Veterinary Physiology College of Medicine, Chonbuk National University Iksan, Republic of Korea (J. H. Kim); Department of Integrative Biotechnology, Biomedical Institute for Convergence of SKKU (BICS), Sungkyunkwan University, Suwon 16419, Republic of Korea (J.Y. Cho).Background: Korean red ginseng extract (KRGE) (Family: Araliaceae) is one of the most widely used traditional herbs in Asia. Multiple studies have shown that KRGE has anti-inflammation, anti-fatigue, anti-obesity, anti-oxidant, and anti-cancer effects. Methods: Sprague-Dawley rats were divided into five groups for PTU-induced hypothyroidism and six groups for LT4-induced hyperthyroidism. At the experiment's conclusion, rats were sacrificed, and blood, thyroid gland, and liver samples were collected. Body weight was recorded weekly, and serum hormone levels were assessed using enzyme-linked immunoassay. Thyroid gland and liver tissues were stained with hematoxylin and eosin. KRGE was prepared in 0.5% CMC and stored at 4 °C before administration. Results: In the LT4-induced hyperthyroidism model, KRGE prevented decreases in body weight, thyroid gland weight, liver weight, serum glucose, and thyroid hormone levels compared to the PTU group. It also reduced increases in T3, T4, and serum aspartate aminotransferase levels after LT4 treatment. Additionally, KRGE improved thyroid gland and liver histopathology, effects not observed in the PTU-induced hypothyroidism model. Conclusion: All things considered, our research points to KRGE's potential protective role in rat hyperthyroidism caused by LT4 by lowering thyroid hormone production.http://www.sciencedirect.com/science/article/pii/S2213422024000519HyperthyroidismHypothyroidismPanax ginsengKorean red ginseng water extractLevothyroxineThyroid stimulating hormone |
| spellingShingle | Lei Huang Won Young Jang Ji Hye Yoon Zhenyan Piao Jinghan Su Dong Seon Kim Ki Woong Kwon Ji Won Kim Sang Hee Park Sunggyu Kim Jong-Hoon Kim Jae Youl Cho Protective effect of Korean red ginseng water extract on levothyroxine-induced hyperthyroidism and propylthiouracil-induced hypothyroidism in rats Integrative Medicine Research Hyperthyroidism Hypothyroidism Panax ginseng Korean red ginseng water extract Levothyroxine Thyroid stimulating hormone |
| title | Protective effect of Korean red ginseng water extract on levothyroxine-induced hyperthyroidism and propylthiouracil-induced hypothyroidism in rats |
| title_full | Protective effect of Korean red ginseng water extract on levothyroxine-induced hyperthyroidism and propylthiouracil-induced hypothyroidism in rats |
| title_fullStr | Protective effect of Korean red ginseng water extract on levothyroxine-induced hyperthyroidism and propylthiouracil-induced hypothyroidism in rats |
| title_full_unstemmed | Protective effect of Korean red ginseng water extract on levothyroxine-induced hyperthyroidism and propylthiouracil-induced hypothyroidism in rats |
| title_short | Protective effect of Korean red ginseng water extract on levothyroxine-induced hyperthyroidism and propylthiouracil-induced hypothyroidism in rats |
| title_sort | protective effect of korean red ginseng water extract on levothyroxine induced hyperthyroidism and propylthiouracil induced hypothyroidism in rats |
| topic | Hyperthyroidism Hypothyroidism Panax ginseng Korean red ginseng water extract Levothyroxine Thyroid stimulating hormone |
| url | http://www.sciencedirect.com/science/article/pii/S2213422024000519 |
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