Clinico-microbiological profile and antibiotic sensitivity pattern of chronic suppurative otitis media with cholesteatoma
Abstract Background To determine microbiological profile (Aerobic, Anaerobic, and Fungal) and antibiotic sensitivity pattern in isolated microbes in Chronic Suppurative Otitis Media (CSOM) with cholesteatoma. This prospective study had been done at tertiary level hospital & medical college in We...
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SpringerOpen
2025-08-01
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| Series: | The Egyptian Journal of Otolaryngology |
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| Online Access: | https://doi.org/10.1186/s43163-025-00881-9 |
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| author | Janvi Bhavsar Rachana Prajapati Jayman Raval R. G. Aiyer |
| author_facet | Janvi Bhavsar Rachana Prajapati Jayman Raval R. G. Aiyer |
| author_sort | Janvi Bhavsar |
| collection | DOAJ |
| description | Abstract Background To determine microbiological profile (Aerobic, Anaerobic, and Fungal) and antibiotic sensitivity pattern in isolated microbes in Chronic Suppurative Otitis Media (CSOM) with cholesteatoma. This prospective study had been done at tertiary level hospital & medical college in Western part of India for one and a half year. 55 number of patients, who were diagnosed as active CSOM with cholesteatoma clinically or in HRCT temporal bone were included. Samples of ear discharge & cholesteatoma were sent to microbiology laboratory for the isolation of organisms & then studied for the antibiotic sensitivity pattern. Postoperatively follow up was carried out at 1st, 2nd, and 3rd months looking for cavity after giving antibiotic to pattern as per sensitivity. Results Among 42 (76.36%) bacterial isolate, Pseudomonas Spp. 19 (34.54%) was the predominant bacteria; followed by Staphylococcus Aureus 07(12.72%) & Proteus Mirabilis 04 (7.27%). Pseudomonas was sensitive to antibiotics- Levofloxacin (84.21%), Imipenem (68.42%), Cefepime (68.42%), Ceftazidime (57.89%). Conclusions Pseudomonas Aeruginosa was the most common aerobic bacteria isolated in this study, followed by Staphylococcus Aureus. While, anaerobic bacteria isolated in present study was Bacteroides and fungus was Aspergillus Niger. Pseudomonas Aeruginosa showed highest susceptibility for Levofloxacin followed by Imipenem, Cefepime, Ceftazidime and high resistance against Co-trimoxazole and Ampicillin. Though the treatment of CSOM with cholesteatoma is surgical, pre-operative isolation of organisms and their drug sensitivity pattern will not only improve cavity healing but also help in prevention of resistant strain and complications. |
| format | Article |
| id | doaj-art-b780d3d8787b4469a00af8f56bb3b6bd |
| institution | DOAJ |
| issn | 2090-8539 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Otolaryngology |
| spelling | doaj-art-b780d3d8787b4469a00af8f56bb3b6bd2025-08-20T03:04:21ZengSpringerOpenThe Egyptian Journal of Otolaryngology2090-85392025-08-014111610.1186/s43163-025-00881-9Clinico-microbiological profile and antibiotic sensitivity pattern of chronic suppurative otitis media with cholesteatomaJanvi Bhavsar0Rachana Prajapati1Jayman Raval2R. G. Aiyer3Department of E.N.T. and Head-Neck surgery, Baroda Medical College and S. S. G. HospitalDepartment of E.N.T. and Head-Neck Surgery, GMERS Medical college GotriDepartment of E.N.T. and Head-Neck surgery, Baroda Medical College and S. S. G. HospitalDepartment of E.N.T. and Head-Neck surgery, Baroda Medical College and S. S. G. HospitalAbstract Background To determine microbiological profile (Aerobic, Anaerobic, and Fungal) and antibiotic sensitivity pattern in isolated microbes in Chronic Suppurative Otitis Media (CSOM) with cholesteatoma. This prospective study had been done at tertiary level hospital & medical college in Western part of India for one and a half year. 55 number of patients, who were diagnosed as active CSOM with cholesteatoma clinically or in HRCT temporal bone were included. Samples of ear discharge & cholesteatoma were sent to microbiology laboratory for the isolation of organisms & then studied for the antibiotic sensitivity pattern. Postoperatively follow up was carried out at 1st, 2nd, and 3rd months looking for cavity after giving antibiotic to pattern as per sensitivity. Results Among 42 (76.36%) bacterial isolate, Pseudomonas Spp. 19 (34.54%) was the predominant bacteria; followed by Staphylococcus Aureus 07(12.72%) & Proteus Mirabilis 04 (7.27%). Pseudomonas was sensitive to antibiotics- Levofloxacin (84.21%), Imipenem (68.42%), Cefepime (68.42%), Ceftazidime (57.89%). Conclusions Pseudomonas Aeruginosa was the most common aerobic bacteria isolated in this study, followed by Staphylococcus Aureus. While, anaerobic bacteria isolated in present study was Bacteroides and fungus was Aspergillus Niger. Pseudomonas Aeruginosa showed highest susceptibility for Levofloxacin followed by Imipenem, Cefepime, Ceftazidime and high resistance against Co-trimoxazole and Ampicillin. Though the treatment of CSOM with cholesteatoma is surgical, pre-operative isolation of organisms and their drug sensitivity pattern will not only improve cavity healing but also help in prevention of resistant strain and complications.https://doi.org/10.1186/s43163-025-00881-9Chronic suppurative otitis mediaCholesteatomaAntibiotic sensitivityAerobeAnaerobe |
| spellingShingle | Janvi Bhavsar Rachana Prajapati Jayman Raval R. G. Aiyer Clinico-microbiological profile and antibiotic sensitivity pattern of chronic suppurative otitis media with cholesteatoma The Egyptian Journal of Otolaryngology Chronic suppurative otitis media Cholesteatoma Antibiotic sensitivity Aerobe Anaerobe |
| title | Clinico-microbiological profile and antibiotic sensitivity pattern of chronic suppurative otitis media with cholesteatoma |
| title_full | Clinico-microbiological profile and antibiotic sensitivity pattern of chronic suppurative otitis media with cholesteatoma |
| title_fullStr | Clinico-microbiological profile and antibiotic sensitivity pattern of chronic suppurative otitis media with cholesteatoma |
| title_full_unstemmed | Clinico-microbiological profile and antibiotic sensitivity pattern of chronic suppurative otitis media with cholesteatoma |
| title_short | Clinico-microbiological profile and antibiotic sensitivity pattern of chronic suppurative otitis media with cholesteatoma |
| title_sort | clinico microbiological profile and antibiotic sensitivity pattern of chronic suppurative otitis media with cholesteatoma |
| topic | Chronic suppurative otitis media Cholesteatoma Antibiotic sensitivity Aerobe Anaerobe |
| url | https://doi.org/10.1186/s43163-025-00881-9 |
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