Preparation and use of SER/GLU-based DES as a novel and potent catalyst for the green synthesis of pyrazolopyranopyrimidines
Abstract Based on the eutectic point phase diagram, a novel natural deep eutectic solvent (SER/GLU-DES) was prepared by a mixture of one mole of serine (SER) and one mole of glutaric acid (GLU), and characterized by various techniques. Then, it was used as a novel and potent catalyst for the synthes...
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Nature Portfolio
2025-04-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-97469-3 |
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| author | Nastaran Dehnokhalaji Davood Habibi Arezo Monem Afagh Ranjbaran |
| author_facet | Nastaran Dehnokhalaji Davood Habibi Arezo Monem Afagh Ranjbaran |
| author_sort | Nastaran Dehnokhalaji |
| collection | DOAJ |
| description | Abstract Based on the eutectic point phase diagram, a novel natural deep eutectic solvent (SER/GLU-DES) was prepared by a mixture of one mole of serine (SER) and one mole of glutaric acid (GLU), and characterized by various techniques. Then, it was used as a novel and potent catalyst for the synthesis of two sets of biologically important pyrazolopyranopyrimidines via a one-pot four-component condensation reaction of ethyl acetoacetate, hydrazinehydrate/ phenylhydrazine, barbituric acid and aldehydes at 70 °C, in solvent-free conditions. |
| format | Article |
| id | doaj-art-b77f1a037f0c439d811fd1cc42bf9fca |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-b77f1a037f0c439d811fd1cc42bf9fca2025-08-20T02:17:57ZengNature PortfolioScientific Reports2045-23222025-04-0115111310.1038/s41598-025-97469-3Preparation and use of SER/GLU-based DES as a novel and potent catalyst for the green synthesis of pyrazolopyranopyrimidinesNastaran Dehnokhalaji0Davood Habibi1Arezo Monem2Afagh Ranjbaran3Department of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina UniversityDepartment of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina UniversityDepartment of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina UniversityDepartment of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina UniversityAbstract Based on the eutectic point phase diagram, a novel natural deep eutectic solvent (SER/GLU-DES) was prepared by a mixture of one mole of serine (SER) and one mole of glutaric acid (GLU), and characterized by various techniques. Then, it was used as a novel and potent catalyst for the synthesis of two sets of biologically important pyrazolopyranopyrimidines via a one-pot four-component condensation reaction of ethyl acetoacetate, hydrazinehydrate/ phenylhydrazine, barbituric acid and aldehydes at 70 °C, in solvent-free conditions.https://doi.org/10.1038/s41598-025-97469-3SerineGlutaric acidDeep eutectic solventPyrazolopyranopyrimidinesHomogeneous catalysis. |
| spellingShingle | Nastaran Dehnokhalaji Davood Habibi Arezo Monem Afagh Ranjbaran Preparation and use of SER/GLU-based DES as a novel and potent catalyst for the green synthesis of pyrazolopyranopyrimidines Scientific Reports Serine Glutaric acid Deep eutectic solvent Pyrazolopyranopyrimidines Homogeneous catalysis. |
| title | Preparation and use of SER/GLU-based DES as a novel and potent catalyst for the green synthesis of pyrazolopyranopyrimidines |
| title_full | Preparation and use of SER/GLU-based DES as a novel and potent catalyst for the green synthesis of pyrazolopyranopyrimidines |
| title_fullStr | Preparation and use of SER/GLU-based DES as a novel and potent catalyst for the green synthesis of pyrazolopyranopyrimidines |
| title_full_unstemmed | Preparation and use of SER/GLU-based DES as a novel and potent catalyst for the green synthesis of pyrazolopyranopyrimidines |
| title_short | Preparation and use of SER/GLU-based DES as a novel and potent catalyst for the green synthesis of pyrazolopyranopyrimidines |
| title_sort | preparation and use of ser glu based des as a novel and potent catalyst for the green synthesis of pyrazolopyranopyrimidines |
| topic | Serine Glutaric acid Deep eutectic solvent Pyrazolopyranopyrimidines Homogeneous catalysis. |
| url | https://doi.org/10.1038/s41598-025-97469-3 |
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