The effects of vitamin B and D supplementations on autonomic functions and quality of life in children after vasovagal syncope
Aim of the studyThe aim of the study was to assess the effectiveness of vitamin B6, B9, B12, and D3 supplements in reducing symptoms and the frequency of syncope, improving autonomic nervous system functions, and enhancing quality of life (QOL) in children following an episode of vasovagal syncope (...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1553428/full |
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| author | Tetiana Kovalchuk Oksana Boyarchuk Nataliya Balatska |
| author_facet | Tetiana Kovalchuk Oksana Boyarchuk Nataliya Balatska |
| author_sort | Tetiana Kovalchuk |
| collection | DOAJ |
| description | Aim of the studyThe aim of the study was to assess the effectiveness of vitamin B6, B9, B12, and D3 supplements in reducing symptoms and the frequency of syncope, improving autonomic nervous system functions, and enhancing quality of life (QOL) in children following an episode of vasovagal syncope (VVS).Materials and methodsThe study involved 68 adolescents with VVS who consistently took vitamin B and D supplements and returned for the examination after 3 months. The effectiveness of the therapy was assessed using the CSSS (Calgary Syncope Seizure Score) and MCSSS (Modified Calgary Syncope Seizure Score), serum vitamin profiles (measured using the ELISA method), heart rate variability, blood pressure variability, and the PedsQL™ (Pediatric Quality of Life Inventory™) 4.0 Generic Core Scales and PedsQL™ 2.0 Family Impact Module surveys.ResultsThe study demonstrated that 3 months of vitamin supplementation were associated with a significant reduction in the frequency of symptoms and syncope episodes (p < 0.05). A marked decrease in serum homocysteine levels was observed, from 13.8 (9.9–17.9) µmol/L to 8.5 (7.6–10.8) µmol/L (p < 0.001). Vitamin supplementation also resulted in improved heart rate variability, evidenced by a significant increase in the SDANN index (p = 0.03) and reductions in TP (p = 0.002), LF (p = 0.004), and LF/HF (p = 0.01), indicating a decrease in sympathotonic influences on the cardiovascular system. Additionally, improved cardiac autonomic function in children with VVS during therapy was reflected by a higher prevalence of dipper profiles for systolic (p = 0.008) and diastolic (p < 0.001) blood pressure. During the 3-month therapy, the QOL in children showed improvements in physical, emotional, and school functioning (p < 0.05). In parents of children with a history of VVS, there were enhancements in physical, emotional, social, and cognitive functioning, as well as in communication and a reduction in worry levels. Among family members, daily activities and family relationships also improved (p < 0.05).ConclusionThe use of vitamin B6, B9, B12, and D3 supplements in therapeutic and preventive doses over 3 months in patients with a history of VVS is associated with a reduction in symptoms and syncope frequency, a decrease in serum homocysteine levels, a reduction in autonomic dysregulation, and an improvement in the QOL for children and their families. |
| format | Article |
| id | doaj-art-b77d01c85e8f4914a54b2ad98d233d6a |
| institution | OA Journals |
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| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj-art-b77d01c85e8f4914a54b2ad98d233d6a2025-08-20T01:57:20ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-03-011310.3389/fped.2025.15534281553428The effects of vitamin B and D supplementations on autonomic functions and quality of life in children after vasovagal syncopeTetiana Kovalchuk0Oksana Boyarchuk1Nataliya Balatska2Department of Pediatrics # 2, Ivan Horbachevsky Ternopil National Medical University of the Ministry of Health of Ukraine, Ternopil, UkraineDepartment of Pediatrics andPediatric Surgery, Ivan Horbachevsky Ternopil National Medical University of the Ministry of Health of Ukraine, Ternopil, UkrainePediatrics Department # 1, Bogomolets National Medical University, Kyiv, UkraineAim of the studyThe aim of the study was to assess the effectiveness of vitamin B6, B9, B12, and D3 supplements in reducing symptoms and the frequency of syncope, improving autonomic nervous system functions, and enhancing quality of life (QOL) in children following an episode of vasovagal syncope (VVS).Materials and methodsThe study involved 68 adolescents with VVS who consistently took vitamin B and D supplements and returned for the examination after 3 months. The effectiveness of the therapy was assessed using the CSSS (Calgary Syncope Seizure Score) and MCSSS (Modified Calgary Syncope Seizure Score), serum vitamin profiles (measured using the ELISA method), heart rate variability, blood pressure variability, and the PedsQL™ (Pediatric Quality of Life Inventory™) 4.0 Generic Core Scales and PedsQL™ 2.0 Family Impact Module surveys.ResultsThe study demonstrated that 3 months of vitamin supplementation were associated with a significant reduction in the frequency of symptoms and syncope episodes (p < 0.05). A marked decrease in serum homocysteine levels was observed, from 13.8 (9.9–17.9) µmol/L to 8.5 (7.6–10.8) µmol/L (p < 0.001). Vitamin supplementation also resulted in improved heart rate variability, evidenced by a significant increase in the SDANN index (p = 0.03) and reductions in TP (p = 0.002), LF (p = 0.004), and LF/HF (p = 0.01), indicating a decrease in sympathotonic influences on the cardiovascular system. Additionally, improved cardiac autonomic function in children with VVS during therapy was reflected by a higher prevalence of dipper profiles for systolic (p = 0.008) and diastolic (p < 0.001) blood pressure. During the 3-month therapy, the QOL in children showed improvements in physical, emotional, and school functioning (p < 0.05). In parents of children with a history of VVS, there were enhancements in physical, emotional, social, and cognitive functioning, as well as in communication and a reduction in worry levels. Among family members, daily activities and family relationships also improved (p < 0.05).ConclusionThe use of vitamin B6, B9, B12, and D3 supplements in therapeutic and preventive doses over 3 months in patients with a history of VVS is associated with a reduction in symptoms and syncope frequency, a decrease in serum homocysteine levels, a reduction in autonomic dysregulation, and an improvement in the QOL for children and their families.https://www.frontiersin.org/articles/10.3389/fped.2025.1553428/fullvitamin Dvitamin Bheart rate variabilityblood pressure variabilityhealth-related quality of lifevasovagal syncope |
| spellingShingle | Tetiana Kovalchuk Oksana Boyarchuk Nataliya Balatska The effects of vitamin B and D supplementations on autonomic functions and quality of life in children after vasovagal syncope Frontiers in Pediatrics vitamin D vitamin B heart rate variability blood pressure variability health-related quality of life vasovagal syncope |
| title | The effects of vitamin B and D supplementations on autonomic functions and quality of life in children after vasovagal syncope |
| title_full | The effects of vitamin B and D supplementations on autonomic functions and quality of life in children after vasovagal syncope |
| title_fullStr | The effects of vitamin B and D supplementations on autonomic functions and quality of life in children after vasovagal syncope |
| title_full_unstemmed | The effects of vitamin B and D supplementations on autonomic functions and quality of life in children after vasovagal syncope |
| title_short | The effects of vitamin B and D supplementations on autonomic functions and quality of life in children after vasovagal syncope |
| title_sort | effects of vitamin b and d supplementations on autonomic functions and quality of life in children after vasovagal syncope |
| topic | vitamin D vitamin B heart rate variability blood pressure variability health-related quality of life vasovagal syncope |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1553428/full |
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