Aromatase Activity and Bone Loss in Men
Aromatase is a specific component of the cytochrome P450 enzyme system responsible for the transformation of androgen precursors into estrogens. This enzyme is encoded by the CYP19A1 gene located at chromosome 15q21.2, that is, expressed in ovary and testis, but also in many extraglandular sites suc...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.4061/2011/230671 |
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| author | Daniela Merlotti Luigi Gennari Konstantinos Stolakis Ranuccio Nuti |
| author_facet | Daniela Merlotti Luigi Gennari Konstantinos Stolakis Ranuccio Nuti |
| author_sort | Daniela Merlotti |
| collection | DOAJ |
| description | Aromatase is a specific component of the cytochrome P450 enzyme system responsible for the transformation of androgen precursors into estrogens. This enzyme is encoded by the CYP19A1 gene located at chromosome 15q21.2, that is, expressed in ovary and testis, but also in many extraglandular sites such as the placenta, brain, adipose tissue, and bone. The activity of aromatase regulates the concentrations of estrogens with endocrine, paracrine, and autocrine effects on target issues including bone. Importantly, extraglandular aromatization of circulating androgen precursors is the major source of estrogen in men. Clinical and experimental evidences clearly indicate that aromatase activity and estrogen production are necessary for longitudinal bone growth, the attainment of peak bone mass, pubertal growth spurt, epiphyseal closure, and normal bone remodeling in young individuals. Moreover, with aging, individual differences in aromatase activity may significantly affect bone loss and fracture risk in men. |
| format | Article |
| id | doaj-art-b77ab62c8f9e43e882d89f011d0fd221 |
| institution | OA Journals |
| issn | 2042-0064 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Osteoporosis |
| spelling | doaj-art-b77ab62c8f9e43e882d89f011d0fd2212025-08-20T02:19:18ZengWileyJournal of Osteoporosis2042-00642011-01-01201110.4061/2011/230671230671Aromatase Activity and Bone Loss in MenDaniela Merlotti0Luigi Gennari1Konstantinos Stolakis2Ranuccio Nuti3Department of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, Viale Bracci 1, 53100 Siena, ItalyDepartment of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, Viale Bracci 1, 53100 Siena, ItalyDepartment of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, Viale Bracci 1, 53100 Siena, ItalyDepartment of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, Viale Bracci 1, 53100 Siena, ItalyAromatase is a specific component of the cytochrome P450 enzyme system responsible for the transformation of androgen precursors into estrogens. This enzyme is encoded by the CYP19A1 gene located at chromosome 15q21.2, that is, expressed in ovary and testis, but also in many extraglandular sites such as the placenta, brain, adipose tissue, and bone. The activity of aromatase regulates the concentrations of estrogens with endocrine, paracrine, and autocrine effects on target issues including bone. Importantly, extraglandular aromatization of circulating androgen precursors is the major source of estrogen in men. Clinical and experimental evidences clearly indicate that aromatase activity and estrogen production are necessary for longitudinal bone growth, the attainment of peak bone mass, pubertal growth spurt, epiphyseal closure, and normal bone remodeling in young individuals. Moreover, with aging, individual differences in aromatase activity may significantly affect bone loss and fracture risk in men.http://dx.doi.org/10.4061/2011/230671 |
| spellingShingle | Daniela Merlotti Luigi Gennari Konstantinos Stolakis Ranuccio Nuti Aromatase Activity and Bone Loss in Men Journal of Osteoporosis |
| title | Aromatase Activity and Bone Loss in Men |
| title_full | Aromatase Activity and Bone Loss in Men |
| title_fullStr | Aromatase Activity and Bone Loss in Men |
| title_full_unstemmed | Aromatase Activity and Bone Loss in Men |
| title_short | Aromatase Activity and Bone Loss in Men |
| title_sort | aromatase activity and bone loss in men |
| url | http://dx.doi.org/10.4061/2011/230671 |
| work_keys_str_mv | AT danielamerlotti aromataseactivityandbonelossinmen AT luigigennari aromataseactivityandbonelossinmen AT konstantinosstolakis aromataseactivityandbonelossinmen AT ranuccionuti aromataseactivityandbonelossinmen |