An Innovative Mathematical Model: A Key to the Riddle of HbA1c
HbA1c is a standard clinical assessment of glycemia and the basis of most data relating glycemic control to complications. While daily blood glucose testing gives a picture of day-to-day fluctuations, the HbA1c test offers an overview of how well glucose has been controlled over the past 4 months. I...
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Wiley
2010-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2010/481326 |
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| author | Mahdi Kahrom |
| author_facet | Mahdi Kahrom |
| author_sort | Mahdi Kahrom |
| collection | DOAJ |
| description | HbA1c is a standard clinical assessment of glycemia and the basis of most data relating glycemic control to complications. While daily blood glucose testing gives a picture of day-to-day fluctuations, the HbA1c test offers an overview of how well glucose has been controlled over the past 4 months. I devised an innovative mathematical model to describe novel equations governing HbA1c which enables analysis of HbA1c behavior and provides emerging new concepts in assessment of diabetes management. Linear relationship of HbA1c and mean plasma glucose along with the kinetic analysis of HbA1c formation has been used as the basic suppositions to construct this model. The main application of this devised model is prediction of mean plasma glucose at any desired point in time after a change in therapy and with great certainty. This model also appraises the pattern of HbA1c changes over time and provides a unique opportunity to address common mistakes and misconceptions in routine application of HbA1c that could have potentially important implications on diabetes control. |
| format | Article |
| id | doaj-art-b7797fef3e3a48c8af23a5a403b390d5 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-b7797fef3e3a48c8af23a5a403b390d52025-08-20T03:39:29ZengWileyInternational Journal of Endocrinology1687-83371687-83452010-01-01201010.1155/2010/481326481326An Innovative Mathematical Model: A Key to the Riddle of HbA1cMahdi Kahrom0Division of Endocrinology and Metabolism, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad 9195977178, IranHbA1c is a standard clinical assessment of glycemia and the basis of most data relating glycemic control to complications. While daily blood glucose testing gives a picture of day-to-day fluctuations, the HbA1c test offers an overview of how well glucose has been controlled over the past 4 months. I devised an innovative mathematical model to describe novel equations governing HbA1c which enables analysis of HbA1c behavior and provides emerging new concepts in assessment of diabetes management. Linear relationship of HbA1c and mean plasma glucose along with the kinetic analysis of HbA1c formation has been used as the basic suppositions to construct this model. The main application of this devised model is prediction of mean plasma glucose at any desired point in time after a change in therapy and with great certainty. This model also appraises the pattern of HbA1c changes over time and provides a unique opportunity to address common mistakes and misconceptions in routine application of HbA1c that could have potentially important implications on diabetes control.http://dx.doi.org/10.1155/2010/481326 |
| spellingShingle | Mahdi Kahrom An Innovative Mathematical Model: A Key to the Riddle of HbA1c International Journal of Endocrinology |
| title | An Innovative Mathematical Model: A Key to the Riddle of HbA1c |
| title_full | An Innovative Mathematical Model: A Key to the Riddle of HbA1c |
| title_fullStr | An Innovative Mathematical Model: A Key to the Riddle of HbA1c |
| title_full_unstemmed | An Innovative Mathematical Model: A Key to the Riddle of HbA1c |
| title_short | An Innovative Mathematical Model: A Key to the Riddle of HbA1c |
| title_sort | innovative mathematical model a key to the riddle of hba1c |
| url | http://dx.doi.org/10.1155/2010/481326 |
| work_keys_str_mv | AT mahdikahrom aninnovativemathematicalmodelakeytotheriddleofhba1c AT mahdikahrom innovativemathematicalmodelakeytotheriddleofhba1c |