Effectiveness of an exercise and nutrition intervention for older adults with mild cognitive impairment: an open-label double-arm clinical trial
BackgroundWe examined the efficacy of physical exercise with nutritional lectures in preventing cognitive decline among older adults.MethodsThis study included individuals aged ≥65 years who had no dementia. The intervention group underwent a physical exercise training program once a week and attend...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1581400/full |
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| author | Moeko Noguchi-Shinohara Kunihiko Yokoyama Junji Komatsu Kazumi Masuda Mitsunobu Kouno Mitsuhiro Yoshita Kenjiro Ono |
| author_facet | Moeko Noguchi-Shinohara Kunihiko Yokoyama Junji Komatsu Kazumi Masuda Mitsunobu Kouno Mitsuhiro Yoshita Kenjiro Ono |
| author_sort | Moeko Noguchi-Shinohara |
| collection | DOAJ |
| description | BackgroundWe examined the efficacy of physical exercise with nutritional lectures in preventing cognitive decline among older adults.MethodsThis study included individuals aged ≥65 years who had no dementia. The intervention group underwent a physical exercise training program once a week and attended nutritional lectures once a month for 5 months. Baseline and 12-month cognitive assessments using the MCI Screen (MCIS) to measure memory performance were completed by individuals in the intervention (n = 76) and nonparticipant (n = 36) groups. The primary endpoint was changes in the memory performance index (MPI) scores of the MCIS.ResultsThe MPI score significantly increased by 1.8 in the intervention group and significantly decreased by 1.2 in the nonparticipant groups (p = 0.049).DiscussionMemory declines gradually overtime as a normal process of aging. Therefore, the decline of MPI score in the nonparticipant group is a natural change, however interestingly, the MPI scores improved in the intervention group, suggesting that the physical exercise with nutritional lectures may prevent memory function. Our results also suggest that through physical exercises and nutritional lectures, older adults might have developed exercise habits that increased their muscle weight which might have improved their cognitive function. A 5-month intervention of our physical exercise training program with nutritional lectures for older adults without dementia can improve their memory performance, especially individuals with 60s and 70s and with mild cognitive impairment. |
| format | Article |
| id | doaj-art-b77230be6a1b4b2eb7e1aabd2622ea0b |
| institution | OA Journals |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-b77230be6a1b4b2eb7e1aabd2622ea0b2025-08-20T02:14:54ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-05-011710.3389/fnagi.2025.15814001581400Effectiveness of an exercise and nutrition intervention for older adults with mild cognitive impairment: an open-label double-arm clinical trialMoeko Noguchi-Shinohara0Kunihiko Yokoyama1Junji Komatsu2Kazumi Masuda3Mitsunobu Kouno4Mitsuhiro Yoshita5Kenjiro Ono6Department of Neurology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, JapanDepartment of Thyroidology, Public Central Hospital of Matto Ishikawa, Hakusan, JapanDepartment of Neurology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, JapanFaculty of Human Sciences, Kanazawa University, Kanazawa, JapanFaculty of Health Sciences, Kinjo University, Hakusan, JapanDepartment of Neurology, National Hospital Organization, Hokuriku National Hospital, Nanto, JapanDepartment of Neurology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, JapanBackgroundWe examined the efficacy of physical exercise with nutritional lectures in preventing cognitive decline among older adults.MethodsThis study included individuals aged ≥65 years who had no dementia. The intervention group underwent a physical exercise training program once a week and attended nutritional lectures once a month for 5 months. Baseline and 12-month cognitive assessments using the MCI Screen (MCIS) to measure memory performance were completed by individuals in the intervention (n = 76) and nonparticipant (n = 36) groups. The primary endpoint was changes in the memory performance index (MPI) scores of the MCIS.ResultsThe MPI score significantly increased by 1.8 in the intervention group and significantly decreased by 1.2 in the nonparticipant groups (p = 0.049).DiscussionMemory declines gradually overtime as a normal process of aging. Therefore, the decline of MPI score in the nonparticipant group is a natural change, however interestingly, the MPI scores improved in the intervention group, suggesting that the physical exercise with nutritional lectures may prevent memory function. Our results also suggest that through physical exercises and nutritional lectures, older adults might have developed exercise habits that increased their muscle weight which might have improved their cognitive function. A 5-month intervention of our physical exercise training program with nutritional lectures for older adults without dementia can improve their memory performance, especially individuals with 60s and 70s and with mild cognitive impairment.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1581400/fullphysical exercisenutritioninterventiondementiamild cognitive impairmentcognitive decline |
| spellingShingle | Moeko Noguchi-Shinohara Kunihiko Yokoyama Junji Komatsu Kazumi Masuda Mitsunobu Kouno Mitsuhiro Yoshita Kenjiro Ono Effectiveness of an exercise and nutrition intervention for older adults with mild cognitive impairment: an open-label double-arm clinical trial Frontiers in Aging Neuroscience physical exercise nutrition intervention dementia mild cognitive impairment cognitive decline |
| title | Effectiveness of an exercise and nutrition intervention for older adults with mild cognitive impairment: an open-label double-arm clinical trial |
| title_full | Effectiveness of an exercise and nutrition intervention for older adults with mild cognitive impairment: an open-label double-arm clinical trial |
| title_fullStr | Effectiveness of an exercise and nutrition intervention for older adults with mild cognitive impairment: an open-label double-arm clinical trial |
| title_full_unstemmed | Effectiveness of an exercise and nutrition intervention for older adults with mild cognitive impairment: an open-label double-arm clinical trial |
| title_short | Effectiveness of an exercise and nutrition intervention for older adults with mild cognitive impairment: an open-label double-arm clinical trial |
| title_sort | effectiveness of an exercise and nutrition intervention for older adults with mild cognitive impairment an open label double arm clinical trial |
| topic | physical exercise nutrition intervention dementia mild cognitive impairment cognitive decline |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1581400/full |
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