The relationship between insulin resistance, bone mineral density, and fracture risk in postmenopausal women
Background/Aim. Skeletal muscles and bones are essential tissues that, in addition to supporting the body, are the primary site of postprandial glucose intake, which is significantly associated with insulin resistance. The aim of this study was to determine the effect of insulin resistance on bone m...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2022-01-01
|
| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502100041B.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850241814495232000 |
|---|---|
| author | Bazić-Sretenović Danijela Veselinovć Mirjana Nikolić-Turnić Tamara Azanjac Anja Korićanac Aleksandra Tomić-Lučić Aleksandra |
| author_facet | Bazić-Sretenović Danijela Veselinovć Mirjana Nikolić-Turnić Tamara Azanjac Anja Korićanac Aleksandra Tomić-Lučić Aleksandra |
| author_sort | Bazić-Sretenović Danijela |
| collection | DOAJ |
| description | Background/Aim. Skeletal muscles and bones are essential tissues that, in addition to supporting the body, are the primary site of postprandial glucose intake, which is significantly associated with insulin resistance. The aim of this study was to determine the effect of insulin resistance on bone mineral density (BMD) and fracture risk and re-evaluate the relationship between muscle properties and BMD and insulin resistance in postmenopausal women in Serbia. Methods. Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) was calculated in postmenopausal women who were divided into two groups. The “cut-off” value of insulin resistance for the group with “Low HOMA-IR” was < 2, and for “High HOMA-IR” > 2. Fat mass (FM), lean mass (LM), and BMD were measured on the hip and spine using a densitometer with dual-energy X-ray absorptiometry. Results. FM and LM had an evident impact on BMD. The decrease in LM and fat buildup was associated with a higher incidence of insulin resistance. A positive correlation was confirmed between HOMA-IR and BMD on the spine and hip, but there was no correlation between insulin resistance and fracture risk. Conclusion. LM and FM have significant effects on BMD. The association between LM, FM, BMD and the onset of insulin resistance in postmenopausal women is confirmed. However, women with higher insulin resistance levels and higher BMD do not have a lower fracture risk. |
| format | Article |
| id | doaj-art-b76f40e98d53471e98c12a8d0d8f0370 |
| institution | OA Journals |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-b76f40e98d53471e98c12a8d0d8f03702025-08-20T02:00:28ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202022-01-0179765866510.2298/VSP210216041B0042-84502100041BThe relationship between insulin resistance, bone mineral density, and fracture risk in postmenopausal womenBazić-Sretenović Danijela0https://orcid.org/0000-0002-4501-9237Veselinovć Mirjana1Nikolić-Turnić Tamara2https://orcid.org/0000-0002-9105-1350Azanjac Anja3Korićanac Aleksandra4Tomić-Lučić Aleksandra5https://orcid.org/0000-0002-1895-7519University of Kragujevac, Faculty of Medical Sciences, Department of Internal Medicine, Kragujevac, Serbia + University Clinical Center Kragujevac, Clinic for Internal Medicine, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Department of Internal Medicine, Kragujevac, Serbia + University Clinical Center Kragujevac, Clinic for Internal Medicine, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Department of Clinical Pharmacy, Kragujevac, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Department of Internal Medicine, Kragujevac, Serbia + University Clinical Center Kragujevac, Clinic for Internal Medicine, Kragujevac, SerbiaGeneral Hospital Kraljevo, Department of Internal Medicine, Kraljevo, SerbiaUniversity of Kragujevac, Faculty of Medical Sciences, Department of Internal Medicine, Kragujevac, Serbia + University Clinical Center Kragujevac, Clinic for Internal Medicine, Kragujevac, SerbiaBackground/Aim. Skeletal muscles and bones are essential tissues that, in addition to supporting the body, are the primary site of postprandial glucose intake, which is significantly associated with insulin resistance. The aim of this study was to determine the effect of insulin resistance on bone mineral density (BMD) and fracture risk and re-evaluate the relationship between muscle properties and BMD and insulin resistance in postmenopausal women in Serbia. Methods. Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) was calculated in postmenopausal women who were divided into two groups. The “cut-off” value of insulin resistance for the group with “Low HOMA-IR” was < 2, and for “High HOMA-IR” > 2. Fat mass (FM), lean mass (LM), and BMD were measured on the hip and spine using a densitometer with dual-energy X-ray absorptiometry. Results. FM and LM had an evident impact on BMD. The decrease in LM and fat buildup was associated with a higher incidence of insulin resistance. A positive correlation was confirmed between HOMA-IR and BMD on the spine and hip, but there was no correlation between insulin resistance and fracture risk. Conclusion. LM and FM have significant effects on BMD. The association between LM, FM, BMD and the onset of insulin resistance in postmenopausal women is confirmed. However, women with higher insulin resistance levels and higher BMD do not have a lower fracture risk.http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502100041B.pdfbone densityfractures, boneinsulin resistancepostmenopauserisk assessmentserbia |
| spellingShingle | Bazić-Sretenović Danijela Veselinovć Mirjana Nikolić-Turnić Tamara Azanjac Anja Korićanac Aleksandra Tomić-Lučić Aleksandra The relationship between insulin resistance, bone mineral density, and fracture risk in postmenopausal women Vojnosanitetski Pregled bone density fractures, bone insulin resistance postmenopause risk assessment serbia |
| title | The relationship between insulin resistance, bone mineral density, and fracture risk in postmenopausal women |
| title_full | The relationship between insulin resistance, bone mineral density, and fracture risk in postmenopausal women |
| title_fullStr | The relationship between insulin resistance, bone mineral density, and fracture risk in postmenopausal women |
| title_full_unstemmed | The relationship between insulin resistance, bone mineral density, and fracture risk in postmenopausal women |
| title_short | The relationship between insulin resistance, bone mineral density, and fracture risk in postmenopausal women |
| title_sort | relationship between insulin resistance bone mineral density and fracture risk in postmenopausal women |
| topic | bone density fractures, bone insulin resistance postmenopause risk assessment serbia |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2022/0042-84502100041B.pdf |
| work_keys_str_mv | AT bazicsretenovicdanijela therelationshipbetweeninsulinresistancebonemineraldensityandfractureriskinpostmenopausalwomen AT veselinovcmirjana therelationshipbetweeninsulinresistancebonemineraldensityandfractureriskinpostmenopausalwomen AT nikolicturnictamara therelationshipbetweeninsulinresistancebonemineraldensityandfractureriskinpostmenopausalwomen AT azanjacanja therelationshipbetweeninsulinresistancebonemineraldensityandfractureriskinpostmenopausalwomen AT koricanacaleksandra therelationshipbetweeninsulinresistancebonemineraldensityandfractureriskinpostmenopausalwomen AT tomiclucicaleksandra therelationshipbetweeninsulinresistancebonemineraldensityandfractureriskinpostmenopausalwomen AT bazicsretenovicdanijela relationshipbetweeninsulinresistancebonemineraldensityandfractureriskinpostmenopausalwomen AT veselinovcmirjana relationshipbetweeninsulinresistancebonemineraldensityandfractureriskinpostmenopausalwomen AT nikolicturnictamara relationshipbetweeninsulinresistancebonemineraldensityandfractureriskinpostmenopausalwomen AT azanjacanja relationshipbetweeninsulinresistancebonemineraldensityandfractureriskinpostmenopausalwomen AT koricanacaleksandra relationshipbetweeninsulinresistancebonemineraldensityandfractureriskinpostmenopausalwomen AT tomiclucicaleksandra relationshipbetweeninsulinresistancebonemineraldensityandfractureriskinpostmenopausalwomen |