Roux-en-Y gastric bypass-associated fecal tyramine promotes colon cancer risk via increased DNA damage, cell proliferation, and inflammation

Roux-en-Y gastric bypass-associated fecal tyramine promotes colon cancer risk via increased DNA damage, cell proliferation, and inflammation

Abstract Background Fecal abundances of Enterobacteriaceae and Enterococcaceae are elevated in patients following Roux-en-Y gastric bypass (RYGB) surgery. Concurrently, fecal concentrations of tyramine, derived from gut bacterial metabolism of tyrosine and/or food, increased post-RYGB. Furthermore,...

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Bibliographic Details
Main Authors: Maria Glymenaki, Sophie Curio, Smeeta Shrestha, Qi Zhong, Laura Rushton, Rachael Barry, Mona El-Bahrawy, Julian R. Marchesi, Yulan Wang, Nigel J. Gooderham, Nadia Guerra, Jia V. Li
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Microbiome
Subjects:
Colon cancer risk
Bariatric surgery
Prevention
Inflammatory bowel disease (IBD)
Host-microbial interaction
Online Access:https://doi.org/10.1186/s40168-025-02049-2
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