Protective Effects of Aqueous Extract of Baillonella toxisperma Stem Bark on Dexamethasone-Induced Insulin Resistance in Rats
The aim of this study was to evaluate the effects of the aqueous extract of Baillonella toxisperma stem bark on dexamethasone-induced insulin resistance in rats. A quantitative phytochemical study was done on the aqueous extract of Baillonella toxisperma for the total phenol, flavonoid, and flavonol...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Advances in Pharmacological Sciences |
| Online Access: | http://dx.doi.org/10.1155/2019/8075163 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849395822905524224 |
|---|---|
| author | Marius Trésor Wego Sylviane Laure Poualeu Kamani David Miaffo Moise Legentil Nchouwet Albert Kamanyi Sylvie Léa Wansi Ngnokam |
| author_facet | Marius Trésor Wego Sylviane Laure Poualeu Kamani David Miaffo Moise Legentil Nchouwet Albert Kamanyi Sylvie Léa Wansi Ngnokam |
| author_sort | Marius Trésor Wego |
| collection | DOAJ |
| description | The aim of this study was to evaluate the effects of the aqueous extract of Baillonella toxisperma stem bark on dexamethasone-induced insulin resistance in rats. A quantitative phytochemical study was done on the aqueous extract of Baillonella toxisperma for the total phenol, flavonoid, and flavonol determination. Insulin resistance was induced by intraperitoneal injection of dexamethasone (1 mg/kg) for 8 days, one hour before oral administration of different treatments (extract at doses of 60, 120, and 240 mg/kg and metformin at 40 mg/kg). During the test, body weight and blood glucose level were evaluated on days 1 and 8. At the last day of treatment, the glucose tolerance test was performed in rats; after that, blood samples were collected for triglycerides, total cholesterol, LDL and HDL cholesterols, transaminases (ALT and AST), and total protein level determination. Organs (heart, liver, pancreas, and kidneys) were also collected for the relative organ weight determination. The results showed that the aqueous extract of B. toxisperma is rich in total phenols, flavonoids, and flavonols. This extract significantly reversed the metabolic alterations (lipid profile, protein level, and transaminase activity) induced by dexamethasone in rats. At doses of 120 and 60 mg/kg, Baillonella toxisperma also significantly decreases (p<0.05; p<0.01) postprandial hyperglycemia in insulin resistance rats. The results suggest that Baillonella toxisperma can manage insulin resistance and may be useful for the treatment of type 2 diabetes mellitus. |
| format | Article |
| id | doaj-art-b7658bb987a14aff8d2ffe7cd119195e |
| institution | Kabale University |
| issn | 1687-6334 1687-6342 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological Sciences |
| spelling | doaj-art-b7658bb987a14aff8d2ffe7cd119195e2025-08-20T03:39:29ZengWileyAdvances in Pharmacological Sciences1687-63341687-63422019-01-01201910.1155/2019/80751638075163Protective Effects of Aqueous Extract of Baillonella toxisperma Stem Bark on Dexamethasone-Induced Insulin Resistance in RatsMarius Trésor Wego0Sylviane Laure Poualeu Kamani1David Miaffo2Moise Legentil Nchouwet3Albert Kamanyi4Sylvie Léa Wansi Ngnokam5Department of Animal Biology, Faculty of Science, University of Dschang, P. O. Box 67 Dschang, Dschang, CameroonDepartment of Animal Biology, Faculty of Science, University of Dschang, P. O. Box 67 Dschang, Dschang, CameroonDepartment of Life and Earth Sciences, Higher Teachers’ Training College, University of Maroua, P. O. Box 55 Maroua, Maroua, CameroonDepartment of Animal Biology, Faculty of Science, University of Dschang, P. O. Box 67 Dschang, Dschang, CameroonDepartment of Animal Biology, Faculty of Science, University of Dschang, P. O. Box 67 Dschang, Dschang, CameroonDepartment of Animal Biology, Faculty of Science, University of Dschang, P. O. Box 67 Dschang, Dschang, CameroonThe aim of this study was to evaluate the effects of the aqueous extract of Baillonella toxisperma stem bark on dexamethasone-induced insulin resistance in rats. A quantitative phytochemical study was done on the aqueous extract of Baillonella toxisperma for the total phenol, flavonoid, and flavonol determination. Insulin resistance was induced by intraperitoneal injection of dexamethasone (1 mg/kg) for 8 days, one hour before oral administration of different treatments (extract at doses of 60, 120, and 240 mg/kg and metformin at 40 mg/kg). During the test, body weight and blood glucose level were evaluated on days 1 and 8. At the last day of treatment, the glucose tolerance test was performed in rats; after that, blood samples were collected for triglycerides, total cholesterol, LDL and HDL cholesterols, transaminases (ALT and AST), and total protein level determination. Organs (heart, liver, pancreas, and kidneys) were also collected for the relative organ weight determination. The results showed that the aqueous extract of B. toxisperma is rich in total phenols, flavonoids, and flavonols. This extract significantly reversed the metabolic alterations (lipid profile, protein level, and transaminase activity) induced by dexamethasone in rats. At doses of 120 and 60 mg/kg, Baillonella toxisperma also significantly decreases (p<0.05; p<0.01) postprandial hyperglycemia in insulin resistance rats. The results suggest that Baillonella toxisperma can manage insulin resistance and may be useful for the treatment of type 2 diabetes mellitus.http://dx.doi.org/10.1155/2019/8075163 |
| spellingShingle | Marius Trésor Wego Sylviane Laure Poualeu Kamani David Miaffo Moise Legentil Nchouwet Albert Kamanyi Sylvie Léa Wansi Ngnokam Protective Effects of Aqueous Extract of Baillonella toxisperma Stem Bark on Dexamethasone-Induced Insulin Resistance in Rats Advances in Pharmacological Sciences |
| title | Protective Effects of Aqueous Extract of Baillonella toxisperma Stem Bark on Dexamethasone-Induced Insulin Resistance in Rats |
| title_full | Protective Effects of Aqueous Extract of Baillonella toxisperma Stem Bark on Dexamethasone-Induced Insulin Resistance in Rats |
| title_fullStr | Protective Effects of Aqueous Extract of Baillonella toxisperma Stem Bark on Dexamethasone-Induced Insulin Resistance in Rats |
| title_full_unstemmed | Protective Effects of Aqueous Extract of Baillonella toxisperma Stem Bark on Dexamethasone-Induced Insulin Resistance in Rats |
| title_short | Protective Effects of Aqueous Extract of Baillonella toxisperma Stem Bark on Dexamethasone-Induced Insulin Resistance in Rats |
| title_sort | protective effects of aqueous extract of baillonella toxisperma stem bark on dexamethasone induced insulin resistance in rats |
| url | http://dx.doi.org/10.1155/2019/8075163 |
| work_keys_str_mv | AT mariustresorwego protectiveeffectsofaqueousextractofbaillonellatoxispermastembarkondexamethasoneinducedinsulinresistanceinrats AT sylvianelaurepoualeukamani protectiveeffectsofaqueousextractofbaillonellatoxispermastembarkondexamethasoneinducedinsulinresistanceinrats AT davidmiaffo protectiveeffectsofaqueousextractofbaillonellatoxispermastembarkondexamethasoneinducedinsulinresistanceinrats AT moiselegentilnchouwet protectiveeffectsofaqueousextractofbaillonellatoxispermastembarkondexamethasoneinducedinsulinresistanceinrats AT albertkamanyi protectiveeffectsofaqueousextractofbaillonellatoxispermastembarkondexamethasoneinducedinsulinresistanceinrats AT sylvieleawansingnokam protectiveeffectsofaqueousextractofbaillonellatoxispermastembarkondexamethasoneinducedinsulinresistanceinrats |