Integrative analysis of T cell-associated markers in Ewing sarcoma reveals prognostic signatures and immune dynamics

Integrative analysis of T cell-associated markers in Ewing sarcoma reveals prognostic signatures and immune dynamics

BackgroundEwing sarcoma (ES) is a rare and aggressive pediatric bone malignancy with poor prognosis, driven by therapy-resistant tumor microenvironments (TME). The TME plays a critical role in tumor progression through a complex and dynamic network of reciprocal interactions among immune cells (dysf...

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Bibliographic Details
Main Authors: Umair Ali Khan Saddozai, Chenxu Liu, Fei Yan, Zhendong Lu, Muhammad Babar Khawar, Muhammad Usman Akbar, Saadullah Khattak, Haibo Sun, Ping Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
Ewing sarcoma
T cell associated genes
immune infiltration
prognostic signature
proliferation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1586544/full
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