Impaired Sequential Working Memory in Patients With Young Onset Parkinson's Disease
ABSTRACT Background Sequential working memory refers to the cognitive ability to maintain and/or manipulate a set of ordered representations within a short period. It remains unclear whether sequential working memory is impaired in patients with young onset Parkinson's disease (YOPD). Objective...
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Wiley
2024-12-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.70182 |
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| author | Guanyu Zhang Shuo Zhang Zhenzhen Zhao Jinghong Ma Piu Chan Zheng Ye |
| author_facet | Guanyu Zhang Shuo Zhang Zhenzhen Zhao Jinghong Ma Piu Chan Zheng Ye |
| author_sort | Guanyu Zhang |
| collection | DOAJ |
| description | ABSTRACT Background Sequential working memory refers to the cognitive ability to maintain and/or manipulate a set of ordered representations within a short period. It remains unclear whether sequential working memory is impaired in patients with young onset Parkinson's disease (YOPD). Objectives The aim of this study is to evaluate the sequential working memory in patients with YOPD. Methods Sixty‐three YOPD patients (29 women) and one hundred age‐ and education‐matched healthy controls participated in three well‐established sequential working memory tests. The YOPD patients were categorized into akinetic rigid type (PD‐ART) and non‐akinetic rigid type (PD‐NART). Participants were asked to maintain digit sequences in mind in the digit span forward (DST‐F) and to maintain and manipulate digit sequences in mind in the digit span backward (DST‐B) and adaptive digit ordering tests (DOT‐A). Results The PD‐ART group scored lower and had higher ordering costs (difference between the DST‐F and DOT‐A scores) than the healthy control group in the DOT‐A. Moreover, in the PD‐ART group, the daily levodopa equivalent dose for dopamine D2/3 receptor agonists positively correlated with the DOT‐A score and negatively correlated with the DOT‐A ordering cost, suggesting that patients who took a greater dose of dopamine D2/3 receptor agonists tended to have higher DOT‐A scores and lower DOT‐A ordering costs. Conclusions These results indicated that the impaired sequential working memory may be one of markers of identifying early cognitive impairment in patients with YOPD, especially in PD‐ART patients. The dopamine D2/3 receptor agonists can recover this impairment to some extent. |
| format | Article |
| id | doaj-art-b75b3efbaf8b48228649fcfbf75f7d78 |
| institution | DOAJ |
| issn | 2162-3279 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
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| series | Brain and Behavior |
| spelling | doaj-art-b75b3efbaf8b48228649fcfbf75f7d782025-08-20T02:50:48ZengWileyBrain and Behavior2162-32792024-12-011412n/an/a10.1002/brb3.70182Impaired Sequential Working Memory in Patients With Young Onset Parkinson's DiseaseGuanyu Zhang0Shuo Zhang1Zhenzhen Zhao2Jinghong Ma3Piu Chan4Zheng Ye5China Institute of Sport ScienceBeijingChinaDepartment of NeurologyTaian Hospital of Traditional Chinese MedicineTaianChinaDepartment of Geriatrics CenterThe Fourth People's Hospital of ShenyangShenyangChinaDepartment of NeurologyXuanwu Hospital of Capital Medical UniversityBeijingChinaDepartment of Neurobiology, Neurology and Geriatrics, Beijing Institute of GeriatricsXuanwu Hospital of Capital Medical UniversityBeijingChinaInstitute of Neuroscience, Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghaiChinaABSTRACT Background Sequential working memory refers to the cognitive ability to maintain and/or manipulate a set of ordered representations within a short period. It remains unclear whether sequential working memory is impaired in patients with young onset Parkinson's disease (YOPD). Objectives The aim of this study is to evaluate the sequential working memory in patients with YOPD. Methods Sixty‐three YOPD patients (29 women) and one hundred age‐ and education‐matched healthy controls participated in three well‐established sequential working memory tests. The YOPD patients were categorized into akinetic rigid type (PD‐ART) and non‐akinetic rigid type (PD‐NART). Participants were asked to maintain digit sequences in mind in the digit span forward (DST‐F) and to maintain and manipulate digit sequences in mind in the digit span backward (DST‐B) and adaptive digit ordering tests (DOT‐A). Results The PD‐ART group scored lower and had higher ordering costs (difference between the DST‐F and DOT‐A scores) than the healthy control group in the DOT‐A. Moreover, in the PD‐ART group, the daily levodopa equivalent dose for dopamine D2/3 receptor agonists positively correlated with the DOT‐A score and negatively correlated with the DOT‐A ordering cost, suggesting that patients who took a greater dose of dopamine D2/3 receptor agonists tended to have higher DOT‐A scores and lower DOT‐A ordering costs. Conclusions These results indicated that the impaired sequential working memory may be one of markers of identifying early cognitive impairment in patients with YOPD, especially in PD‐ART patients. The dopamine D2/3 receptor agonists can recover this impairment to some extent.https://doi.org/10.1002/brb3.70182akinetic rigid typedopamine D2/3 receptor agonistsneuropsychological testssequential working memoryyoung onset Parkinson's disease |
| spellingShingle | Guanyu Zhang Shuo Zhang Zhenzhen Zhao Jinghong Ma Piu Chan Zheng Ye Impaired Sequential Working Memory in Patients With Young Onset Parkinson's Disease Brain and Behavior akinetic rigid type dopamine D2/3 receptor agonists neuropsychological tests sequential working memory young onset Parkinson's disease |
| title | Impaired Sequential Working Memory in Patients With Young Onset Parkinson's Disease |
| title_full | Impaired Sequential Working Memory in Patients With Young Onset Parkinson's Disease |
| title_fullStr | Impaired Sequential Working Memory in Patients With Young Onset Parkinson's Disease |
| title_full_unstemmed | Impaired Sequential Working Memory in Patients With Young Onset Parkinson's Disease |
| title_short | Impaired Sequential Working Memory in Patients With Young Onset Parkinson's Disease |
| title_sort | impaired sequential working memory in patients with young onset parkinson s disease |
| topic | akinetic rigid type dopamine D2/3 receptor agonists neuropsychological tests sequential working memory young onset Parkinson's disease |
| url | https://doi.org/10.1002/brb3.70182 |
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