Expert perspectives on the use of safinamide for Parkinson’s disease in Portugal: insights from a Portuguese Delphi Consensus
Aim: Safinamide is an approved medication for managing motor fluctuations in Parkinson’s disease (PD). However, limited data exist regarding its application in clinical practice in Portugal and the perspectives of Portuguese neurologists on its use. To address this, a group of Portuguese specialis...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Becaris Publishing Limited
2025-01-01
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| Series: | Journal of Comparative Effectiveness Research |
| Subjects: | |
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| Summary: | Aim: Safinamide is an approved medication for managing motor fluctuations in Parkinson’s disease (PD).
However, limited data exist regarding its application in clinical practice in Portugal and the perspectives
of Portuguese neurologists on its use. To address this, a group of Portuguese specialists with recognized
expertise in PD management convened to compile the insights on various aspects of safinamide use
in PD patients among the field and to develop recommendations aimed at informing and guiding
physicians in Portugal on its optimal clinical application. Materials & methods: A focus group composed
of nine Portuguese PD experts developed a questionnaire building on the 2022 European Delphi study,
and employed a Delphi methodology approach to gather the views of Portuguese neurologists with a
minimum of 5 years of clinical experience with safinamide (n = 35). A final online questionnaire comprising
35 statements was administered in a single-round Delphi format, utilizing a 5-point Likert scale. Consensus
was defined as achieving ≥66% agreement or disagreement among the panelists. Results: A strong
consensus emerged among Portuguese neurologists regarding the therapeutic efficacy of safinamide
in addressing motor symptoms, motor fluctuations and quality of life. Additionally, agreement was
reached on its positive effects on nonmotor symptoms such as sleep, fatigue, mood, quality of life and
pain management. However, no consensus was achieved regarding safinamide’s efficacy in managing
orthostatic hypotension, cognitive issues, urinary and sexual dysfunction, as well as its safety profile in PD
patients with hallucinations. Overall, the opinions of Portuguese neurologists aligned closely with those
of their European counterparts. Conclusion: This Delphi study highlights the consensus among Portuguese
neurologists on the efficacy of safinamide for managing motor symptoms in PD. The considerations
presented herein offer essential guidance for effectively managing PD with safinamide, ultimately
enhancing patient care in Portugal. |
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| ISSN: | 2042-6313 |